Inflammatory Disease and the Human Microbiome - Amy D Proal - Discovery Medicine. Abstract: The human body is a superorganism in which thousands of microbial genomes continually interact with the human genome.
A range of physical and neurological inflammatory diseases are now associated with shifts in microbiome composition. Seemingly disparate inflammatory conditions may arise from similar disruption of microbiome homeostasis. Intracellular pathogens long associated with inflammatory disease are able to slow the innate immune response by dysregulating activity of the VDR nuclear receptor.
This facilitates the ability of other species to gradually accumulate in tissue and blood, where they generate proteins and metabolites that significantly interfere with the body’s metabolic processes. The microbes that contribute to this dysfunction are often inherited from family members. Introduction. The Inflammatory Cortisol Ballet Part 1.
This is a post from the Gut Critters blog that ended November1 8, 2016. Ray Medina gave permission for his material to be copied as long as it was attributed to him and not used for commercial purposes. – kiraonysko
The Inflammatory Cortisol Ballet Part 2.
This is a post from the Gut Critters blog that ended November 18, 2016. Ray Medina gave permission for his material to be copied as long as it was attributed to him and not used for commercial purposes. – kiraonysko
The Inflammatory Cortisol Ballet Part 3. Butyric Acid: an Ancient Controller of Metabolism, Inflammation and Stress Resistance? An Interesting Finding Susceptible strains of rodents fed high-fat diets overeat, gain fat and become profoundly insulin resistant.
Dr. Jianping Ye's group recently published a paper showing that the harmful metabolic effects of a high-fat diet (lard and soybean oil) on mice can be prevented, and even reversed, using a short-chain saturated fatty acid called butyric acid (hereafter, butyrate). Here's a graph of the percent body fat over time of the two groups: The butyrate-fed mice remained lean and avoided metabolic problems. Butyrate lowered their blood cholesterol by approximately 25 percent, and their triglycerides by nearly 50 percent. Health Diagrams III — Inflammation from Cell to Tissue. I have explained my perspective in diagrams of the relationship between diet, gut flora and disease: and of the interaction between gut flora, the immune system and autoimmunity: Now I am discussing how inflammation, the foundation of most chronic diseases, begins at the cellular level and results in the classic symptoms of tissue inflammation: redness, heat, swelling and pain.
NF-kB is the Transcription Factor that Controls Inflammation Genes Of the 23,000 human genes, about 1,000 on each of 23 chromosomes, five dozen, e.g. enzymes involved in nitric oxide (vasodilation and erection hormone), synthesis of heparin sulfate and prostaglandin synthesis from omega-6 fatty acids or cytokines (IL-1, IL-6, TNFa), are associated with inflammation. Inflammation is the Foundation of Growth, Birth, Cancer and Pain We think of inflammation as the sum of physical symptoms, and our purpose in responding to inflammation is typically to limit its impact. NSAIDs Inhibit Inflammatory Prostaglandin Production. Functional profiling of the gut microbiome in disease-associated inflammation. The roles of the gut microbiota in inflammatory conditions have begun to be unraveled by functional profiling, or the assessment of host and microbial biomolecular activity in tandem with microbial community structure.
Assessment using nucleotide sequencing is typically a two-step process. First, genes, proteins, or protein families in the community (and sometimes in the host) are quantified; second, individual gene families are merged into higher-level pathways, such as metabolic pathways and functional modules. There are several experimental assays and computational methods designed to accomplish these steps, and the choice of method depends on the nature of the microbial community under investigation, as well as the sequencing data available to describe it. Considerations in the choice and application of analysis methods are briefly summarized here and reviewed in depth elsewhere . Meta'omic data are typically interpreted by first assigning sequences to gene families .
The Interplay Between Fiber and the Intestinal Microbiome in the Inflammatory Response. Introduction The nutritional importance of fiber has been long recognized.
Fiber has been included in the Nutrition Facts label following the 1990 Nutrition Labeling and Education Act, which sets the daily value (DV)3 for fiber at 12 g/1000 kcal. The 1997 revision of the Dietary Reference Intakes (DRI) established the adequate intake of fiber at ∼14 g/1000 kcal (1). At ∼13 g/1000 kcal (50 g/kg diet), the calculated nutrient density of fiber in purified rodent diets, such as AIN-76 and AIN-93, is similar to the human recommendation (2, 3). Unfortunately, the presence of these recommendations does not signify a complete understanding of fiber nutrition. The focus of this review is on the multifaceted role of fiber in modulating tissue inflammation, locally in the intestine and systemically. Top 19 Antinutrients in Plant Based Foods That Can Cause Inflammation - Selfhacked. Data Mining The Microbiome Toward A Cure For Inflammatory Disease. The Gut Microbiota in Immune-Mediated Inflammatory Diseases. Strange, parasitic microbiome bacteria may responsible for inflammatory diseases — The American Microbiome Institute.