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Autoimmune Disorders / The Immune System and the Gut Microbiome

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Disruption of the gut microbiome may be an important piece of the puzzle for autoimmune disorders. Realize that it isn't the whole picture. Genetic vulnerabilities, trauma, stress, environmental pollutants, EMF radiation and mold exposure can also play a role.

Also see the section on special diets for information on the autoimmune protocol and the section on celiac. Often celiac (with or without digestive symptoms) starts the cascade that results in autoimmunity. List of autoimmune diseases - Wikipedia. Autoimmune Diseases Qualifiers[edit] Overview of the qualifiers for the list.

List of autoimmune diseases - Wikipedia

Autoimmune Diseases[edit] Major Organs[edit] Glands[edit] Digestive System[edit] Tissue[edit] Autoimmune Comorbidities[edit] This list includes conditions that are not diseases but signs common to autoimmune disease. Non-Autoimmune[edit] At this time, there is not sufficient evidence - direct, indirect, or circumstantial - to indicate that these diseases are caused by autoimmunity.


Arthritis. Chronic Fatigue Syndrome (CFS) Lupus. How Your Gut Flora Shapes Your Immune System.

This is a post from the Gut Critters blog that ended November 18, 2016. Ray Medina gave permission for his material to be copied as long as it was attributed to him and not used for commercial purposes. – kiraonysko

Video: Reshaping the immune system: Moises Velazquez-Manoff at TEDxCibeles. Microbes Fight Chronic Infection. Clostridium difficile sporesWIKIMEDIA, CJC2NDPatients who’d rather not ingest another’s fecal matter to fight tenacious cases of Clostridium difficile infections (CDI) may soon have a less stomach-turning, and perhaps safer, alternative.

Microbes Fight Chronic Infection

According to a genetic sequencing analysis of intestinal microbes, a small handful of bacterial species may be all that are needed to restore health. The study, published today (October 23) in Nature, suggests that the bacteria protect against infection by altering the composition of bile acids in the gut. What do the bacteria living in your gut have to do with your immune system? Your intestines are home to many different kinds of bacteria (and some non-bacterial organisms as well).

What do the bacteria living in your gut have to do with your immune system?

Together they’re called the “gut microbiome.” They come from the food you eat – and whatever else gets into your mouth. Bacteria start colonizing your gut at birth. Your gut microbiome aids in digestion and produces vitamins and other compounds that affect your health. It seems to play a role in many other health-related functions, including metabolism, cardiac health and mood. Immune Response Promotes Infection. Salmonella enterica serovar TyphimuriumWIKIMEDIA, CDCSome immune responses are known to backfire.

Immune Response Promotes Infection

Autoimmunity is a well-documented case of this phenomenon. Now, researchers show that the pathogenic bacterium Salmonella enterica serovar Typhimurium can exploit a standard immune response to promote its own growth. In a study published today (February 6) in Immunity, a team led by Manuela Raffatellu from the University of California, Irvine, reports having exposed mice with and without an immune signal molecule interleukin 22 (IL-22) to Salmonella infection.

The researchers found that mice lacking IL-22 could combat the infection. But normal mice with IL-22 did not fare as well. “[This study] takes several counterintuitive observations in the field and connects them to a coherent picture—a daring ‘Battle of the Bugs,’” said microbiologist Sebastian Winter, from the UT Southwestern Medical Center in Dallas, Texas, who was not involved in the work. J. Gut Microbes May Hasten HIV to AIDS Progression. The arrival of anti-retroviral therapy, a combination of medications used to slow the progression of HIV, has allowed many people infected with the virus to live long, productive lives.

Gut Microbes May Hasten HIV to AIDS Progression

But the therapy is not a cure. And those who take the drugs have an elevated risk for cardiovascular disease, cancer, kidney and liver disease, and other disorders seen in HIV patients. HIV infection also can lead to diseases affecting the intestines, with increased gastrointestinal (GI) inflammation, diarrhea and problems with nutrient absorption. The role of gut microbes in such issues is not completely understood, but now, in two studies led by researchers at Washington University School of Medicine in St. Louis, scientists have identified intestinal bacteria and viruses as possible sources of such inflammation and disease. Does the Gut Microbiome Play a Role in Autoimmune Disease? Connections between gut microbiota and autoimmune disease.

Systemic lupus erythematosus (SLE) is a chronical autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue.

Connections between gut microbiota and autoimmune disease

It can affect the skin, joints, kidneys, the brain and other organs. From Gut to Immune System to Brain…pay the toll with potatoes! Within our body are small structures called “Toll-like Receptors (TLRs).”

From Gut to Immune System to Brain…pay the toll with potatoes!

These receptors are an important part of our immune system. TLRs are used by components of our immune system to detect the presence of microbes, ie. fungal and bacterial pathogens, that do not belong inside of us, and need to be eliminated. This is a key feature of our “innate immune system.” The innate immune system is our first-line defense against microbial infections. Prolonged over-stimulation of our innate immune system leads to chronic inflammation and a steady decline in health, often resulting in autoimmune diseases such as diabetes, arthritis, Crohn’s disease, etc… The list is long. RS2 as an Immunity Booster. Resetting the Gut Microbiome Offers Potential Treatment for Rare Autoimmune Disease. Defective regulatory T cells (Tregs) alter the gut microbiome, leading to a variety of autoimmune diseases.

Resetting the Gut Microbiome Offers Potential Treatment for Rare Autoimmune Disease

New findings suggest that replacing absent gut bacteria or restoring a key metabolite could help treat children with IPEX syndrome. IPEX syndrome is a rare and often fatal autoimmune disease that occurs when mutations in the transcription factor, Foxp3, disrupts Treg function. Patients who do not receive a stem cell transplant usually die before 2 years of age. Celiac and Other Autoimmune Disorders. In celiac, immune cells fight ferociously against a crumb of bread, damaging the small intestine in the process.

Celiac and Other Autoimmune Disorders

Gluten, normally innocuous, leaks out of the small intestines of people with celiac disease, triggering a sequence of cellular activity more appropriate for fighting off a deadly salmonella infection. Celiac disease is not to be confused with gluten intolerance or other phrases used lightly by people seeking to eat healthily, says Alice Bast, president and CEO of the National Foundation for Celiac Awareness. “Celiac disease is a serious genetic autoimmune disease,” Bast says.

She repeats, with emphasis: “Serious. Early symptoms of possible auto-immune (FM/CFS/ etc) onset. There are two onset patterns seen with most CFS: sudden and gradual onset.

Early symptoms of possible auto-immune (FM/CFS/ etc) onset

Sudden onset is associated strongly as a post-infection retaining of an altered microbiome. The gut bacteria did not return to normal after being farmed by the infection. A patient did recover from the infection, NOT — the organism causing the disease was eliminated, but the trauma to the gut bacteria stayed on.Gradual onset lacks this ability to identify a point of time (or the point of time was sufficiently insignificant that memory of it is lost). Autoimmune and Vitamin 1,25D. I thought that I should put together a collection on conditions that have been documented to have a high Vitamin 1,25D result(Calcitriol) when tested. ” Results showed a strong positive association between these autoimmune conditions[ multiple sclerosis, lupus, psoriasis, osteoporosis, osteoarthritis, metabolic syndrome, fibromyalgia and chronic fatigue syndrome] and levels of 1,25-D >110 pmol/L.

However, there was little association with vitamin D deficiency or the other inflammatory markers, meaning that the results challenge the assumption that serum levels of 25-D are a sensitive measure of the autoimmune disease state.” [2009]“In granulomatous disease such as lymphoproliferative disorders, sarcoidosis, tuberculosis, and inflammatory bowel disease,”[emedicine]“postural orthostatic tachycardia syndrome” – remission with calcitriol treatment [2012] General Vitamin D level and symptoms. Autoimmunity and the Gut. The Gut Microbiota in Immune-Mediated Inflammatory Diseases.

The microbiome modulates the function of specific cells of the immune system — The American Microbiome Institute. Regulatory B cells are specific white blood cells that are involved in protecting the body and have the ability to differentiate (or turn into) other types of immune cells in response to inflammation in the body. Their role is to regulate and restrain immune responses by producing the anti-inflammatory interleukin-10 but it is unclear what specific signals cause regulatory B cells to differentiate. Video: Prebiotics: Tending Our Inner Garden.

Video: Immunology in the Gut Mucosa. Immune system helps ‘good’ bacteria fight off ‘bad’ microbes. Over millions of years of evolution, humans and their gut microorganisms get on well and have a mutually beneficial relationship. We provide the microorganisms with shelter and nourishment and in exchange, these hundreds of trillions of tiny microbes living inside us contribute to our health and metabolism by performing different and important tasks.

One key function is how they help us keep harmful, potentially infection-causing bacteria at bay. And in this important job, they are not alone. “Our study reveals how our body’s immune system shapes the gut microbiota to naturally limit infections,” said senior author Yang-Xin Fu, a professor at the University of Chicago Department of Pathology, in a statement. "Gut"-throat competition: U-M research on digestive tract bacteria yields surprising findings. Photo Credit: U-M - Nunez Laboratory Two views of pathogenic bacteria attached to the gut lining ANN ARBOR, Mich. - From tiny villages in developing nations to suburban kitchens in the United States, dangerous strains of E. coli bacteria sicken millions of people each year – and kill untold numbers of children.

Now, new research from the University of Michigan Health System gives scientists a better understanding of what is going on in the diarrhea-wracked guts of its victims, and what might be done to prevent or treat it. Video: How Nutrition Can Shape Gut Microbiota - Alessio Fasano (2016) (1.5 h) Video: Lifestyle and Autoimmune Disease — Sarah Ballantyne, Ph.D. (AHS14) (38 minutes) The microbiome and innate immunity : Nature : Nature Research. A network of interactions characterizes the interdependence between the innate immune system and the microbiota8. The two systems affect one another to orchestrate whole-organism physiology. Epithelial cells. Which comes first: the leaky gut or the dysfunctional immune system? - The Paleo Mom.

Video on Autoimmune & Bacteria + Best Eczema Report Yet. Video Talk: How the Human Microbiome causes Human Chronic Disease (25 minutes) Chronic Diseases Can’t Be Cured? I was just doing a little side-digging on rheumatoid arthritis — an autoimmune, inflammatory condition — and came across this line on the Arthritis Foundation website: “Rheumatoid arthritis is a chronic disease, meaning it can’t be cured.” Food as Medicine. Modifying the Paleo Diet for Autoimmune Conditions - The Paleo Mom. Female Gut, Fiber, Autoimmune: Do Women Need More Fiber Than Men? Female Hormones, Weight and Auto-Immunity - The Paleo Mom. Health Diagrams II — Curing Autoimmunity and Allergies. Educate Your Immune System. The study, published last year, was small. But for Ramnik Xavier, a molecular biologist at the Broad Institute in Cambridge, Mass., and a senior author on the study, the findings suggested for the first time that intervention might be possible. Your Microbial Garden - Balancing your Immune System.

This is a list of papers and resources. – kiraonysko

Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Diet, Microbiota and Autoimmune Diseases. New discoveries related to gut microbiota and multiple sclerosis - Gut Microbiota for Health. Could the gut microbiota be a new potential target for multiple sclerosis treatment and prevention? - Gut Microbiota for Health. Brain Microbiota Imbalances in MS Patients May Be Link to Demyelination. The microbiome and osteomyelitis, an autoinflammatory bone disease — The American Microbiome Institute. The nature of immune responses to urinary tract infections : Nature Reviews Immunology : Nature Research. Gut Microbes May Trigger Eye Disease. Bacteria to Blame for Autoimmune Uveitis? Helminths suppress the immune system by modulating the gut microbiota — The American Microbiome Institute. Can hookworms fight against celiac disease? — The American Microbiome Institute. The human microbiome and autoimmunity.