Obesity is Inflammatory Disease, Rat Study Shows. Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans.
PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself. Zucker Rat, a pet rat that has developed diabetes as a result of a genetic disorder that causes obesity. Image credit: Joanna Servaes / CC BY-SA 3.0. “This important new finding links obesity and high fat, high sugar diets with changes in immune cells and inflammatory status, highlighting an emerging realization that obesity is an inflammatory disease,” Dr Fairlie said. Lim J et al. 2013. Research Findings on Memory and Cognitive Impairment in ECT. Dr.
Peter Como presented to the U.S. Food and Drug Administration Neurological Devices Panel examining the reclassification of electroconvulsive therapy (ECT) devices on January 27, 2011. This presentation comes from the public record of the meeting. The FDA systematic review of the literature of cognitive adverse events [of ECT] included only randomized controlled trials as I mentioned. However, we did examine data from crossover designs if analyzable pre-crossover data were available. The statistical comparisons that were examined included comparisons among various ECT treatment conditions, such as electrode placement, energy dose, frequency of treatment, waveform, and pulse.
From this literature search, a total of 68 studies were identified which met these criteria. Role of the bed nucleus of the stria termina... [Eur J Pharmacol. 2003. Clinical Motor and Cognitive Neurobehavioral Relationships in the Basal Ganglia. 1.
Introduction The traditional view that the basal ganglia and cerebellum are simply involved in the control of movement has been challenged in recent years. One of the pivotal reasons for this reappraisal has been new information about basal ganglia and cerebellar connections with the cerebral cortex. In essence, recent anatomical studies have revealed that these connections are organized into discrete circuits or ‘loops’. Rather than serving as a means for widespread cortical areas to gain access to the motor system, these loops reciprocally interconnect a large and diverse set of cerebral cortical areas with the basal ganglia and cerebellum. Parkinson’s and Alzheimer’s Diseases: Similar But Very Different. As people live longer and the world population grows older, late-onset disorders such as Parkinson’s disease and Alzheimer’s disease will affect more and more individuals.
Both of these diseases are neurodegenerative and typically begin late in life, so many people assume that they are related or linked in some way. Let’s take a look at how much truth there is to that idea. First of all, the two diseases are not related but they do share some similarities. Both Alzheimer’s and Parkinson’s disease have an onset that is late in life, usually after the age of 50. Both diseases are neurodegenerative, meaning that brain cells (neurons) become damaged and die during the course of the disease.
James Parkinson Biography. Doctor, Geologist, Neurologist, Activist, Scientist (1755–1824) English born, English bred, forgotten by the English and the world, James Parkinson identified the "shaking palsy" as a disease of the central nervous system.
Synopsis Though best known for the nervous disorder that bears his name, James Parkinson was a man of many interests. Medicine, social reform and geology also occupied his attention, and he wrote numerous publications in each of these areas. Parkinson's work on shaking palsy was notable, but as the author his name fell into obscurity until 40 years later, when his name was attached to the disease. Early Life and Training in Medicine James Parkinson was born in London on April 11, 1755, to John and Mary Parkinson.
Few details are known of his medical training, but historians have found clues in Parkinson's writings. In 1781, Parkinson married Mary Dale. Social Reformer Publications Geological Studies. Ethics Education and Psychology: British Psychological Society Critiques DSM-5. The British Psychological Society responds to the new DSM-5. A prior blog post looked at some criticism of the DSM-5. The British Psychological Association offers a more formal, 26-page critique. The entire document can be found here. The first part of the critique is posted for your review. The Society is concerned that clients and the general public are negatively affected by the continued and continuous medicalisation of their natural and normal responses to their experiences; responses which undoubtedly have distressing consequences which demand helping responses, but which do not reflect illnesses so much as normal individual variation.
We therefore do welcome the proposal to include a profile of rating the severity of different symptoms over the preceding month. Diagnostic categories do not predict response to medication or other interventions whereas more specific formulations or symptom clusters might (Moncrieff, 2007).