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Crohn's Disease

Spina Bifida. Stroke. Self-awareness in neurodegenerative disease relies on neural structures mediating reward-driven attention. The neural basis of impaired self-awareness after traumatic brain injury. Post-operative delirium in elderly patients. Donepezil in the Prevention and Treatment of Post-Surgical Delirium. When Will We Solve Mental Illness? The second guidepost concerns the impact of biology.

When Will We Solve Mental Illness?

Although there are several important exceptions, measurable differences in brain biology appear to contribute only a fraction of added risk for developing persistent mental problems. Genetic inheritance surely plays a role, but it falls well short of a stand-alone “cause” in most people who receive a diagnosis. The remainder of the risk is supplied by experience: the messy combination of trauma, substance use, loss and identity crises that make up an individual’s intimate, personal history.

Biology has nothing to say about those factors, but people do. Millions of individuals who develop a disabling mental illness either recover entirely or learn to manage their distress in ways that give them back a full life. Many participants are veterans of the psychiatric system, people who have received multiple diagnoses and decided to leave medical care behind. All Disorders.

Disease vs Disorder

Diagnosis and Diagnoses. ADHD. AIDS. ALS. Alzheimer's. Anxiety. Aphasia Types. Autism. Cerebral Palsy. Chronic Fatigue Biomarkers. People suffering from a debilitating and often discounted disease known as chronic fatigue syndrome may soon have something they’ve been seeking for decades: scientific proof of their ailment.

Chronic Fatigue Biomarkers

Researchers at the Stanford University School of Medicine have created a blood test that can flag the disease, which currently lacks a standard, reliable diagnostic test. “Too often, this disease is categorized as imaginary,” said Ron Davis, PhD, professor of biochemistry and of genetics. When individuals with chronic fatigue syndrome seek help from a doctor, they may undergo a series of tests that check liver, kidney and heart function, as well as blood and immune cell counts, Davis said. “All these different tests would normally guide the doctor toward one illness or another, but for chronic fatigue syndrome patients, the results all come back normal,” he said. The problem, he said, is that they’re not looking deep enough.

COVID-19-Brain

CTE. Depression. Dyslexia. Epilepsy. Prosopagnosia - Face Blindness. Fetal Alcohol Syndrome. Confusion of Amnesia, Analgesia, and Sedation Really a Safety Issue - Anesthesia Patient Safety Foundation. General Question Has OBA Impact To the Editor I address the controversy surrounding the use of conscious IV sedation.

Confusion of Amnesia, Analgesia, and Sedation Really a Safety Issue - Anesthesia Patient Safety Foundation

The discussions continue to examine the qualifications of those prescribing and administering the agents and of those who monitor the patient’s response. The question most frequently asked is, “Is this safe for the patient?” Gerstmann Syndrome - StatPearls - NCBI Bookshelf.

Heart & Memory/Brain problems

Huntington's Disease. The Surprising Solution to the Imposter Syndrome. Korsakoff's Syndrome: A Critical Review - PubMed. In this review, we present a survey on Korsakoff's syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction.

Korsakoff's Syndrome: A Critical Review - PubMed

We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Moreover, recent insights into the underlying neurocognitive mechanisms of these symptoms are presented. In addition, the evidence so far on the etiology of KS is examined, highlighting the role of thiamine and alcohol and discussing the continuity hypothesis.

Parkinson's Disease

Phantom limb. Psychopathy. PTSD. Schizophrenia. Simultagnosia. Split Brain. Tourette Syndrome. Psychosurgeons Use Lasers to Burn Away Mental Illness. Next-Generation Treatments for Mental Disorders. Voices `told woman' she had brain tumour. Low Activity Microstates During Sleep. Ventral Striatum - an overview. Why do viruses often come from bats? A discussion with your friendly neighborhood virologist : science. Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. Prefrontal cortex sleep - PMC - NCBI. Long spaceflights affect astronaut brain volume. Extended periods in space have long been known to cause vision problems in astronauts.

Long spaceflights affect astronaut brain volume

Now a new study in the journal Radiology suggests that the impact of long-duration space travel is more far-reaching, potentially causing brain volume changes and pituitary gland deformation. Spider venom key to pain relief without side-effects. Molecules in tarantula venom could be used as an alternative to opioid pain killers for people seeking chronic pain relief.

Spider venom key to pain relief without side-effects

University of Queensland researchers have designed a novel tarantula venom mini-protein that can potentially relieve severe pain without addiction. Dr Christina Schroeder from UQ's Institute for Molecular Bioscience said the current opioid crisis around the world meant urgent alternatives to morphine and morphine-like drugs, such as fentanyl and oxycodone, were desperately needed. International Journal of Neural Systems. Reel-Example: Conduction Aphasia 1. Obesity is Inflammatory Disease, Rat Study Shows. Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans.

Obesity is Inflammatory Disease, Rat Study Shows

PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself. Zucker Rat, a pet rat that has developed diabetes as a result of a genetic disorder that causes obesity.

Research Findings on Memory and Cognitive Impairment in ECT. Dr.

Research Findings on Memory and Cognitive Impairment in ECT

Peter Como presented to the U.S. Food and Drug Administration Neurological Devices Panel examining the reclassification of electroconvulsive therapy (ECT) devices on January 27, 2011. Role of the bed nucleus of the stria termina... [Eur J Pharmacol. 2003. Ethics Education and Psychology: British Psychological Society Critiques DSM-5.   The British Psychological Society responds to the new DSM-5. A prior blog post looked at some criticism of the DSM-5. The British Psychological Association offers a more formal, 26-page critique. Alien limb syndrome: A Bayesian account of unwanted actions. Alien limb syndrome has attracted a wide public interest due its unusual clinical manifestations (e.g., Mosley, 2011).

Alien limb syndrome: A Bayesian account of unwanted actions

The term ‘alien limb’ itself implies an enigmatic and dramatic nature of an otherwise debilitating disorder. In the clinical context, alien limb refers to the performance of seemingly purposeful or semi-purposeful movements, which patients report as independent of their own intentions or despite the lack of intention. A Case of Right Alien Hand Syndrome Coexisting with Right-Sided Tactile Extinction. Introduction AHS is a bizarre and very rare neurological movement disorder first described by Goldstein (1908).

A Case of Right Alien Hand Syndrome Coexisting with Right-Sided Tactile Extinction

Patients with AHS experience one of their limbs as alien, which acts autonomously and performs goal-directed movements that are not guided by the intention of the patient. For example, patients grasp for objects or touch their face without volition. Patients may even act aggressively against themselves. The patient is aware of the discrepancies between intentions and the actions of the hand. AHS has been reported subsequent to lesions in various brain regions, for example supplementary motor area (SMA), anterior cingulate, corpus callosum, anterior prefrontal cortex, posterior parietal cortex, and thalamus (Goldberg et al., 1981; Martí-Fàbregas et al., 2000; Marey-Lopez et al., 2002; Scepkowski and Cronin-Golomb, 2003; Biran and Chatterjee, 2004; Assal et al., 2007; Fitzgerald et al., 2007; Brainin et al., 2008).

The alien hand syndrome. Brain Fog After Heart Failure Improves with Walking and Brain Games. The older you get, the more likely you are to worry about keeping your memory intact. If you are among the 5.7 million adults in the United States living with heart failure, a potentially fatal condition, you might have another reason for concern—brain fog, a subtle form of memory loss.1 Certainly, losing your mental alertness is something you’d want to avoid or postpone long into the future. To address this concern, a research team from Emory University initiated a study to explored whether people with heart failure who do brain exercises in combination with aerobic exercise might improve their cognitive losses or lessen the forgetfulness that occurs, often too subtle for most individuals to notice.2.