The National Institute of Drug Abuse (NIDA) released the results of its 2011 Monitoring the Future Survey of teen drug use, and guess what: Teens are using cigarettes and alcohol less, but they are smoking more marijuana. What's more, they're smoking more weed because they do not perceive it to be as harmful as did teens in the past. Study: Why Teen Pot Smoking Could be a Good Thing (And What We Can Learn From Teens Who Choose Weed Over Beer)
Cannabinoid receptor CB1 and CB2 structures. There are currently two known subtypes, termed CB1 and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells. Mounting evidence suggests that there are novel cannabinoid receptors that is, non-CB1 and non-CB2, which are expressed in endothelial cells and in the CNS. In 2007, the binding of several cannabinoids to a G protein-coupled receptor (GPCR) in the brain was described. The protein sequences of CB1 and CB2 receptors are about 44% similar. When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is approximately 68%. In addition, minor variations in each receptor have been identified. Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors.
SExpand Archaeologists recently found a 2,700-year-old pot stash, so we know humans have been smoking weed for thousands of years. But it was only about 20 years ago that neuroscientists began to understand how it affects our brains. Scientists have known for a while that the active ingredient in cannabis was a chemical called delta-9-tetrahydrocannabinol, or THC for short. Ingesting or smoking THC has a wide range of effects, from the psychoactive "getting high" to the physiological relief of pain and swelling. It also acts as both a stimulant and depressant.
I damn hate hightimes but I can't find any other write-up about the NIMH study of rat THC receptor sites. Anyway here is the entire hightimes article.Read the whole thing if you have not yet, its enlightening. One of the safest qualities of THC, delta-9 tetrahydrocannabinol, the primary psychoactive substance in marijuana, is the natural limit the body places on the drug's effects. Increase THC receptor sites, get HIGHER!
THC Prevents MDMA Neurotoxicity in Mice. [PLoS One. 2010
Marijuana Munchies Won’t Make You Fat Thanks to some fearless French researchers, we now know that you have nothing to fear from an attack of the munchies, reports Reuters:
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Advanced Joint Rolling, from Spliffigami
Selling drugs is a recession-proof business model. From MSBC: Medical marijuana is now a $1.7 billion market, according to a report released Wednesday by See Change Strategy, an independent financial analysis firm that specializes in new and unique markets. Medical marijuana a blockbuster drug
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