Treatment of Biofilm Infections on Implants with Low-frequency Ultrasound and Antibiotics. Infection-fighting Mesh Developed for Hernia Repair. Researchers have presented data on a new mesh that prevents contamination of implantable surgical devices in open ventral hernia repair by sending out targeted drugs to eliminate bacteria.
The mesh, developed by Memphis-based preclinical stage company Ariste Medical, is the first polypropylene coated antimicrobial graft for open ventral hernia repair, Chief Scientific Officer Dr. Lisa Jennings told Bioscience Technology. Polypropylene is the predominate implant material used for open ventral hernia repair, she said. Which innovative new product has been a game-changer this year? Tell us & win! The company’s current findings, presented April 1 at the 17th Annual Hernia Repair Meeting of the American Hernia Society, showed that the mesh protected, in vitro, against common bacteria for at least 14 days, and also protect against surgical site infections caused by MRSA. Preclinical Bioassay of a Polypropylene Mesh for Hernia Repair Pretreated with Antibacterial Solutions of Chlorhexidine and Allicin: An In Vivo Study.
Abstract Introduction Prosthetic mesh infection constitutes one of the major complications following hernia repair.
Antimicrobial, non-antibiotic biomaterials have the potential to reduce bacterial adhesion to the mesh surface and adjacent tissues while avoiding the development of novel antibiotic resistance. This study assesses the efficacy of presoaking reticular polypropylene meshes in chlorhexidine or a chlorhexidine and allicin combination (a natural antibacterial agent) for preventing bacterial infection in a short-time hernia-repair rabbit model. Methods Partial hernia defects (5 x 2 cm) were created on the lateral right side of the abdominal wall of New Zealand White rabbits (n = 21). Results The polypropylene mesh showed improved tissue integration relative to the DualMesh Plus. Conclusions The presoaking of reticular polypropylene materials with a low concentration of chlorhexidine provides the mesh with antibacterial activity without disrupting tissue integration. Introduction.
Direct demonstration of bacterial biofilms on prosthetic mesh after ventral herniorrhaphy. Biofilm engineer Phil Stewart continues Provost's Distinguished Lecturer Series March 8. BOZEMAN – When Phil Stewart takes stock of his career – as a researcher, educator and administrator with the Center for Biofilm Engineering at Montana State University – he sees research that opened up new terrain in the engineering world.
And, he notes, much of that ground has been broken at MSU by scientists and engineers at the CBE on an interdisciplinary quest to understand the inner workings of biofilms. Biofilms are dense aggregates of bacteria or fungi that stick to virtually any wetted surface – think of a slippery rock in a stream or the dental plaque on your teeth. Biofilms coat everything from oil and gas infrastructure to artificial joints and medical implants cost industry billions of dollars annually in maintenance and lost efficiency. In healthcare, biofilms can lead to expensive hospital stays. Over the past 25-plus years, MSU researchers at the CBE have helped put biofilms on the map by combining engineering and microbiology. Hernia meshes: new answers to an old problem - Engineering. Sheila Grant, associate professor of biological engineering, is studying hernia mesh failure and solutions in her lab, aided by biological engineering undergraduate students, form left, Bryce Romans, Daniel Grant, Sheila Grant, Rachael Fischer and James Benson in the foreground.
According to the National Center for Health statistics, nearly 5 million Americans suffer from the most common types of hernias, which occur in the abdomen. Hernias are bulges caused by organs protruding though weak spots in the muscles that are intended to hold them in place and are sometimes quite dangerous. Hernias are commonly repaired with the insertion of a mesh patch, which can be administered during laparoscopic surgery.
However, these meshes, primarily made of polyester, polypropylene or Teflon, can experience approximately a 10 percent failure rate. “Medical device companies realize the importance of analyzing the meshes,” Grant said. “Companies are starting to listen to us,” Grant said. Baxter : Patent Issued for Method for the Improvement of Mesh Implant Biocompatibility. Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better? Pelvic Mesh Recipient Alleges Bioincompatibility Caused Severe Pain. Written by: Kristin Casler Case Overview Plaintiff suffered from stress urinary incontinence.
She received a pelvic mesh implant that was manufactured by defendant. She alleges that at the time of her surgery, the defendant knew of FDA and medical professionals’ safety concerns about the mesh implants causing vaginal shortening, vaginal tightening and vaginal pain. The mesh caused conditions that required additional surgeries. Plaintiff filed this lawsuit three years after her surgery. Question for Expert Witness 1.
Expert Witness “A small amount of inflammation near the interface between the foreign body and the tissue is related to better biocompatibility. Interview with Dr. Randall Wolcott, bacterial biofilm wound specialist. Patients with diabetic neuropathy may not notice minor injuries due to loss of feeling in their lower extremities.
Since the Vitamin D Receptor is inactivated by bacterial ligands, a small cut or sore can become infected, and flare into a limb- or life-threatening condition in as little as three days. These wounds are so difficult to heal that most of medicine considers them a lost cause and treats them with amputation. Amputations are often considered to be the beginning of the end for patients with diabetes. Dr. Randall Wolcott 70% of diabetics who undergo an amputation die within five years due to the stress placed on their hearts from their altered circulatory system. Nationally, an estimated 82,000 people with diabetes had lower-limb amputations in 2002, according to the Centers for Disease Control.
Before treating the biofilms on his patients’ wounds, Wolcott admitted patients for an estimated 10 to 15 amputations a month. Could you explain what a biofilm is? Consider this. Dr. FOREIGN BODY REACTION TO BIOMATERIALS. Biofilm. Implant_Syndrome_070711.pdf.