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Irritable Bowel Syndrome (IBS)

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5 Causes of IBS Your Doctor May Not Be Looking For. What Are Beneficial Gut Bacteria. Microbiome differences between healthy people and those with IBS — The American Microbiome Institute. IBS affects somewhere around 11% of all humans.

Microbiome differences between healthy people and those with IBS — The American Microbiome Institute

It is not known exactly what causes the disease but it is characterized by a low grade inflammation in the colon which can manifest itself as cramping, bloating, diarrhea, constipation, and overall abdominal discomfort. Many scientists now believe this is a microbiome mediated disease that is caused by some sort of dysbiosis in the gut, unfortunately efforts to characterize exactly what differences occur in IBS individuals have not been successful. Update on Irritable Bowel Syndrome – 2016 news. I thought it would be good to review some of the hundreds of studies published on PubMed in 2016 to see if anything especially interesting has been published.

Update on Irritable Bowel Syndrome – 2016 news

“During life, the numbers of bifidobacteria decrease from up to 90% of the total colon microbiota in vaginally delivered breast-fed infants to <5% in the colon of adults and they decrease even more in that of elderly as well as in patients with certain disorders such as antibiotic-associated diarrhea, inflammatory bowel disease, irritable bowel syndrome, obesity, allergies, and regressive autism.” [2016] ” Butyrate is an essential metabolite in the human colon, as it is the preferred energy source for the colon epithelial cells, contributes to the maintenance of the gut barrier functions, and has immunomodulatory and anti-inflammatory properties.

Researchers identify intestinal microbiota profile related to severity of IBS symptoms - Gut Microbiota for Health. Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder in western societies and recent research has proposed gut microbiota as one of the potential main factors involved.

Researchers identify intestinal microbiota profile related to severity of IBS symptoms - Gut Microbiota for Health

However, little is known regarding the relationship between the composition and function of the gut microbiota and clinical symptoms of IBS. Paired mucosal and faecal microbiota sample analysis in the exploratory set of patients revealed that faecal and mucosal microbiota were structurally distinct but highly correlated. Although there were no differences in faecal microbiota composition between patients with IBS when compared to healthy subjects, a computational statistical procedure identified a microbial signature for severe IBS within the IBS group, consisting of 90 bacterial operational taxonomic units (OTUs), which are the most commonly used microbial diversity units clustered on the basis of deoxyribonucleic acid (DNA) sequence identity alone.

Reference: Gut Bacteria causing Irritable Bowel Syndrome / CFS. While researching my last post I came across an article describing the differences of bacteria seen with IBS.

Gut Bacteria causing Irritable Bowel Syndrome / CFS

We know that two commercially probiotics are effective for treating IBS, so it is nice to know which bacteria they appear to push out. IBS and CFS are co-morbid, so these results likely applies to most CFS patients. Real-time PCR analysis of enteric pathogens from fecal samples of irritable bowel syndrome subjects Teemu Rinttilä12, Anna Lyra13, Lotta Krogius-Kurikka1 and Airi Palva1* “According to the results, the studied clostridial groups (Clostridium histolyticum, Clostridium coccoides-Eubacterium rectale, Clostridium lituseburense and Clostridium leptum) represented the dominant faecal microbiota of most of the studied subjects, comprising altogether 29-87% of the total bacteria” [2006] These author and other studies reports high levels of: The detection was done by looking at RNA sequences.

For new comers to this blog, the two effective probiotics are: IBS Treatment Options.

This is a post from the Gut Critters blog that ended November 18, 2016. Ray Medina gave permission for his material to be copied as long as it was attributed to him and not used for commercial purposes. – kiraonysko

Irritable Bowel Syndrome and Gluten. IBS Probiotics. The following are a list of probiotics effective (i.e. improve, not necessarily cure) Irritable Bowel Syndrome according to studies on PubMed.com.

IBS Probiotics

IBS is co-morbid with CFS and thus they become recommended probiotics for CFS. For this I raised the criteria to studies on humans and not on mice. In general mixtures were eliminated with the exception of “unique mixtures” – Prescript Assist and VSL#3 NOTE: Probiotics do produce natural antibiotics. It is strongly recommended that the probiotics below be rotated and not taken continuously.

“Overall, more than 50% of trials presented negative outcomes. Prescript Assist – multiple species Symbioflor 2 – E.Coli Probiotic Mutaflor — E.Coli Nissle 1917. International guide to help physicians use probiotics. According to the World Health Organization (WHO) and the Food and Agriculture Organization of the United Nations (FAO), probiotics are live microorganisms that, when consumed or administered in adequate amounts, have beneficial effects on the body.

International guide to help physicians use probiotics

Probiotics are also usually used for the prevention and management of digestive symptoms that may be related to changes or an imbalance in the bacterial community living in our gut, the gut microbiota, such as bloating or discomfort, among others. In spite of increasing evidence and knowledge about probiotics, so far, it has not been an easy task for doctors to choose the most appropriate probiotic for each case. This is due to the fact that “probiotics” is an umbrella term that covers a huge range of bacterial strains and other microorganisms.

We are glad to hear about the publication of this new guide as a tool to increase knowledge on the use of probiotics for the management of lower gastrointestinal symptoms in primary care. Diet for IBS – FODMAP. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) A diet low in FODMAPs reduces symptoms of irritable bowel syndrome.Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. [2014]Low FODMAP diet information“Diets differing in FODMAP content have marked effects on gut microbiota composition.

Diet for IBS – FODMAP

The implications of long-term reduction of intake of FODMAPs require elucidation.”[2015]Suggestion: Take Prescript Assist and/or Align concurrent with this diet change, both have been shown effective for IBS. s search c compose new post r reply e edit. Diet and probiotics emerge as promising treatments  “First of all, I think it’s a ‘real’ condition, one that we can recognize fairly readily, [even] given that there are tremendous variations in presentation and natural history,” he tells GMFH editors.

Diet and probiotics emerge as promising treatments 

Dr. Eamonn Quigley of Houston Methodist Hospital (USA) New gut microbiota research — outlined by Quigley in a 2014 review — is contributing to insights about the biological processes that generate IBS symptoms. “There is quite a lot of circumstantial evidence to suggest the microbiome may be relevant. Effectiveness of probiotics in those with IBS - Gut Microbiota for Health.

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, affecting more than 10% of the population, with the highest impact in women.

Effectiveness of probiotics in those with IBS - Gut Microbiota for Health

Although its origin is still unknown, reduced gut microbial diversity could be involved in its development. Clinical trial for probiotics in irritable bowel syndrome fails to show efficacy — The American Microbiome Institute. Irritable bowel syndrome is the most common functional gastrointestinal disorder, affecting about 10-15% of people in the United States alone, according to the International Foundation for Functional Gastrointestinal Disorders website.

Clinical trial for probiotics in irritable bowel syndrome fails to show efficacy — The American Microbiome Institute

Fortunately, as described by the IFFGD, IBS is a functional disorder, meaning that while it does affect quality of life, it does not affect life expectancy. Fibromyalgia IBS and Endotoxemia. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction? Abstract IBS is one of the most common types of functional bowel disorder. Increasing attention has been paid to the causative role of food in IBS.

Food ingestion precipitates or exacerbates symptoms, such as abdominal pain and bloating in patients with IBS through different hypothesised mechanisms including immune and mast cell activation, mechanoreceptor stimulation and chemosensory activation. Wheat is regarded as one of the most relevant IBS triggers, although which component(s) of this cereal is/are involved remain(s) unknown. Gluten, other wheat proteins, for example, amylase-trypsin inhibitors, and fructans (the latter belonging to fermentable oligo-di-mono-saccharides and polyols (FODMAPs)), have been identified as possible factors for symptom generation/exacerbation.

Introduction The mechanisms leading to symptom generation in IBS remain highly debated, although growing knowledge indicates that multiple factors are involved. Mechanisms by which food might induce symptoms Figure 1. Who are the most active Irritable Bowel Syndrome Researchers?