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Biology
Biology is a natural science concerned with the study of life and living organisms , including their structure, function, growth, evolution , distribution, and taxonomy . [ 1 ] Biology has many subdisciplines unified by five so-called axioms of modern biology: [ 2 ] Cells are the basic unit of life Genes are the basic unit of heredity New species and inherited traits are the product of evolution An organism regulates its internal environment to maintain a stable and constant condition Living organisms consume and transform energy
Trends in Biotechnology
From Medical Genomics to Modeling Schizophrenia October 2012 The October Cell Podcast features Trends in Biotechnology author, Andrew Lloyd . He shares how next generation sequencing is opening doors for much improved vaccine design. Read the article by Luciani et al. The full contents of the podcast are: » Developing drugs to tackle schizophrenia, using rodents models, with Mark Geyer (0:00) ( October issue of Trends in Pharmacological Sciences ) » The role of next-gen sequencing in vaccine design, with Andrew Lloyd (8:50) ( September issue of Trends in Biotechnology ) » Interpreting the genome to pinpoint mutations in an inherited blood disorder, with Vijay Sankaran (17:38) (for more on genetic mapping and disease, check out this Primer in Cell ) » Plus, sample a selection of the hottest new papers from Cell Press (23:08)Trends in Cell Biology
April, 2013 Volume 23, Issue 4 Volume 23, Issue 4 The question of how organelle size is controlled has fascinated cell biologists ever since cellular structures were first visualized. The nucleus exhibits exquisite size scaling relative to cell size both during development and between species, and these normal cellular scaling relationships are often abrogated in cancer. In fact, pathologists use altered nuclear size and morphology to diagnose and stage the disease.
Trends in Ecology & Evolution
Special Issue Ecological and evolutionary informatics February's special issue of TREE highlights the growing field of ecological and evolutionary informatics – the collection, open storage and analysis of large data sets. Such an approach to doing science has become routine in the fields of genetics and genomics and has led to many significant advances. By widening awareness of this approach, TREE hopes to help promote similarly important advances in ecology, evolutionary biology and palaeontology. (The figure shows a Google Earth visualisation of a Hawaiian katydid genus.
Volume 92, Issue 3: March 7, 2013 On the cover: James Franklin Crow, Ph.D., President, American Society of Human Genetics, 1963. James F. Crow made historic contributions to the scientific community—and to the public at large—through his research, teaching, public service, ethical analysis, and leadership in the fields of genetics and human genetics.
The American Journal of Human Genetics
Chemistry & Biology
21 March, 2013 Volume 20, Issue 3 Volume 20, Issue 3 On the cover: Niemann-Pick type C1 (NPC1) is an endosomal membrane protein essential for intracellular cholesterol transport; the loss of function due to mutations in this protein is a major cause of Niemann-Pick disease type C. Ohgane et al. (391) report that oxysterol derivatives act as pharmacological chaperones and correct folding-defective phenotypes of NPC1 via direct binding to the protein. Interestingly, these sterol derivatives exert their effect by binding to a sterol-binding site on NPC1 distinct from the well-characterized sterol-binding domain, the N-terminal domain. These findings may provide a rational basis for developing therapeutics and insight into how NPC1 transports cholesterol across the endosomal membrane.
In the March Issue Fungal Defenses against Host Copper Leishmania Targets Host miRNA Processing preview Toxoplasma Protein ARO Mediates Rhoptry Positioning HRas Signals HCV Receptor Complex Assembly Defining Influenza Virus Antigenic Drift HCMV Targets TRAIL Death Receptors RIG-I Recognizes Encapsidated Viral dsRNA preview Chitin Receptor-Mediated Immune Signaling in Plants Redox-Sensitive Cysteines in Pathogenic Bacterial Proteomes Perspective: Antibody-Mediated Immunity against Tuberculosis Next issue: April 17, 2013 Featured Articles free The Featured Articles are freely accessible.
Host & Microbe
Immunity
21 March, 2013 Volume 38, Issue 3 Volume 38, Issue 3 On the cover: Inflammatory monocytes (yellow cells in the railcar) are able to migrate from the bloodstream (blue river) into peripheral tissues (green field) and differentiate into inflammatory macrophages or dendritic cells (left track) to promote inflammation and eliminate pathogens. Egawa et al. (pages 570–580) have demonstrated that this pathway can be redirected toward the generation of anti-inflammatory macrophages (right track), under the influence of interleukin-4 produced by allergen-activated basophils (blue cells), to dampen allergic inflammation in the skin. Cover illustration by Mayumi Egawa.
Online Now Each week, Structure publishes papers online ahead of the print issue. Here are the latest: Follow Structure on Twitter
Structure
Metabolism
Cell Metabolism SnapShot, in collaboration with Cell Cancer Metabolism Pathways Lydia W.S. Finley, Ji Zhang, Jiangbin Ye, Patrick S. Ward, Craig B. Thompson One Year Ago ...
Developmental Cell
Dynamin2 Protects a GEF Dynamin2 promotes metastatic migration not via known effects on intracellular trafficking, but by binding to the Rac1 GEF, Vav1. Dynamin2 protects Vav1 from Hsc70 and lysosomal degradation, enabling Rac activation.Stem Cell
Cell Stem Cell is the official affiliated journal of the International Society for Stem Cell Research (ISSCR). Stem Cell Reports . The ISSCR will launch an open access journal with a focus on shorter single-point articles. Published by Cell Press. Now accepting submissions.Biophysical Journal
Tilting and Wobble of Myosin V by High-Speed Single-Molecule Polarized Fluorescence Microscopy John F. Beausang, Deborah Y. Shroder, Philip C. Nelson, Yale E.Montage of some highly influential scientists from a variety of scientific fields. From left to right: Top row: Archimedes , Aristotle , Ibn al-Haytham , Leonardo da Vinci , Galileo Galilei , Antonie van Leeuwenhoek ; Second row: Isaac Newton , James Hutton , Antoine Lavoisier , John Dalton , Charles Darwin , Gregor Mendel ; Third row: Louis Pasteur , James Clerk Maxwell , Henri Poincaré , Sigmund Freud , Nikola Tesla , Max Planck ; Fourth row: Ernest Rutherford , Marie Curie , Albert Einstein , Niels Bohr , Erwin Schrödinger , Enrico Fermi ; Bottom row: Alan Turing , Richard Feynman , E. O.
Science General
Brain scans predict which criminals are more likely to reoffend Doug Menuez/Getty Neuroimaging 'biomarker' linked to rearrest after incarceration. In a twist that evokes the dystopian science fiction of writer Philip K.
Nature
Ressources Neurosciences