A Fast, Affordable Blood Test Could Change How We Treat Cancer Forever. In Brief A revolutionary technique in oncology research that requires just a simple blood draw shows great promise in detecting cancers early.
A New Treatment Destroyed Breast Cancer Tumors in 11 Days Without Chemo. Drug Combination A new clinical trial demonstrated positive effects caused by the drug combination lapatinib and trastuzumab against HER2 positive breast cancer in a treatment period of just 11 days.
Led by researchers at the Institute of Cancer Research, London, the University of Manchester, and University Hospital of South Manchester, the study comprised 257 women with HER2 positive breast cancer who were split into groups and treated for 11 days prior to surgery. Women who were treated with the drug combination were compared to women who received only one the drugs or no drugs before undergoing surgery. To assess results, samples of the tumor tissue were taken from an initial biopsy and once again during surgery, to determine if there was a drop in Ki67 protein, which indicates cell proliferation.
Susana Soares’ Glass Device Uses Honey Bees to Detect Cancer. At last year’s Dutch Design Week in Eindhoven, Portuguese designer Susana Soares presented a device that can detect cancer and other diseases using honey bees.
Known for their extraordinary sense of smell, bees can detect airborne molecules in the parts per trillion range and can be trained to recognize certain smells associated with diseases such as lung, skin and pancreatic cancer, as well as tuberculosis. The device is made out of two chambers. "Game-Changing" Immunotherapy Drug Doubles Cancer Survival Rates. An immunotherapy drug is being hailed as a “game-changer” by cancer researchers following a successful clinical trial.
In the study, survival rates after one year were more than twice as high among patients who were treated with the drug – called nivolumab – than those who received chemotherapy. Many cancers outsmart the body’s immune system in order to avoid being destroyed by it, which is why scientists are now increasingly focusing on immunotherapy – whereby the immune system is recruited to fight off pathogens – in the quest to defeat cancer. For instance, some cancerous cells give off a signal that prevents T-cells from attacking them, although since nivolumab blocks this signal, researchers had hoped it may help to heal patients. Cutting Out Cancer: CRISPR Gene Editing Could Make Cancer Mutations Inactive. In Brief When CRISPR-Cas9 was developed, it opened up genetic engineering to a number of applications previously thought of as impossible.
Now, German researchers found a way to use this tool to root out cancer mutations. Cancer and CRISPR A group of researchers from Dresden’s National Center for Tumor Disease (NCT), the Medical Faculty of the Technische Universität (TU) Dresden, and the German Consortium for Translational Cancer Research (DKTK), have found a way to use CRISPR-Cas9 to identify and cut out the particular cancer genes that advance mutations.
“Mutations in cancer cells are identified at increasing speed through next generation sequencing, but we mostly do not know, which of these mutations are actually driving the disease and which ones are rather benign,” leading researcher Frank Buchholz said in a journal article. Technology for Killing Metastatic Breast Cancer Cells Discovered, Licensed - UCF News - University of Central Florida Articles. A UCF College of Medicine cancer researcher has discovered a way to kill spreading breast cancer cells and her new technology has generated a licensing agreement that will accelerate the therapy’s path to clinical trials.
Metastatic cancer cells that spread from the original tumor to the brain, lungs and bones are the leading cause of death for most cancer patients, said Annette Khaled, the researcher who made the discovery. Setting the Body’s ‘Serial Killers’ Loose on Cancer. Dr.
June’s 2011 publications did not cite Dr. Rosenberg’s paper from the previous year, prompting Dr. Rosenberg to write a letter to The New England Journal of Medicine. Dr. June’s publications also did not acknowledge that the genetic construct he had used was the one he had obtained from Dr. Explicit cookie consent. “CURE” is not a word much used by oncologists.
The best they normally talk of is “remission”. But the past five years have begun to change that. More than 70 new drugs have come to market, and describing the consequences of some of them as revolutionary is not hyperbole—at least for those patients lucky enough to respond positively to them. New device could improve cancer detection. A new University of British Columbia-developed method to isolate cancer cells that have escaped from a tumour could soon pave the way for improved diagnosis and treatment.
The simple process involves a special device that squeezes cells in a blood sample through tiny funnels, which drive the cancer cells and blood cells into separate streams based on differences in their size and softness. “Circulating tumour cells—cells from a tumour that have escaped into the bloodstream with the potential to spread into other tissues—are extremely useful for assessing a patient’s disease in order to select the most appropriate treatment,” said UBC mechanical engineering professor Hongshen Ma, the lead researcher.
“These cells are particularly important for prostate cancer, where the site of metastasis is typically in the bone, where biopsies are difficult or impossible. Radiation and immunotherapy combination can destroy both primary and secondary tumors. Radiation therapy not only kills cancer cells, but also helps to activate the immune system against their future proliferation.
However, this immune response is often not strong enough to be able to cure tumors, and even when it is, its effect is limited to the area that has been irradiated. Now, however, research to be presented to the ESTRO 35 conference today (Sunday) has shown that the addition of an immune system-strengthening compound can extend the radiation therapy-induced immune response against the tumor sites and that this response even has an effect on tumours outside the radiation field.
A combination of radiation therapy and L19-IL2, an immunotherapy agent, can increase significantly the immune response when given to mice with primary colorectal tumors. Breast cancer: Scientists hail 'milestone' genetic find. Image copyright SPL Scientists say they now have a near-perfect picture of the genetic events that cause breast cancer.
The study, published in Nature, has been described as a "milestone" moment that could help unlock new ways of treating and preventing the disease. The largest study of its kind unpicked practically all the errors that cause healthy breast tissue to go rogue. Nanoparticle ‘cluster bombs’ destroy cancer cells. The nanoparticles start out relatively large (100 nm) (large blue circle, upper left) to enable smooth transport into the tumor through leaky blood vessels. Then, in acidic conditions found close to tumors, the particles discharge “bomblets” (right, small blue circles) just 5 nm in size. Once inside tumor cells, a second chemical step activates the platinum-based drug cisplatin (bottom) to attack the cancer directly. (credit: Emory Health Sciences) Scientists have devised a triple-stage stealth “cluster bomb” system for delivering the anti-cancer chemotherapy drug cisplatin, using nanoparticles designed to break up when they reach a tumor: Doctors have used cisplatin to fight several types of cancer for decades, but toxic side effects — to the kidneys, nerves and inner ear — have limited its effectiveness.
Details of the research — by teams led by professor Jun Wang, PhD, at the University of Science and Technology of China and by professor Shuming Nie, PhD, in the Wallace H. Cancer reversed in frogs by hacking cells’ electricity with light. OUR bodies are electric. It’s not just our brains and hearts – almost every cell has an electrical charge, and hacking it might be a way to treat cancer. Researchers have used light to shift the charge of cancer cells in frogs, making them healthy again.
It’s some way off being a human therapy, but this is the first use of a technique called optogenetics to target cancer, opening up the possibility of treatments that don’t use toxic drugs. “This is just the beginning,” says Michael Levin at Tufts University, Massachusetts. Retrained T-cells cause cancer remission in over 90% of terminally ill acute lymphoblastic leukaemia patients. Experimental, living T-cell therapy shows promise for treating advanced disease, making immunotherapy a ‘pillar’ of cancer care.
Twenty-seven out of 29 patients with an advanced blood cancer who received an experimental, “living” immunotherapy as part of a clinical trial experienced sustained remissions. The trial is designed to test the safety of the latest iteration of an experimental immunotherapy in which a patient’s own T cells are reprogrammed to eliminate his or her cancer. The reprogramming involves genetically engineering the T cells with synthetic molecules called chimeric antigen receptors, or CARs, that enable them to target and destroy tumor cells bearing a particular target. Trial participants include patients with acute lymphoblastic leukemia, non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Merck CEO: Major Breakthrough in Lung Cancer Treatment. Cancer Knocked Out By Measles Vaccine. Multiple myeloma (MM) is a form of cancer that attacks plasma cells, which synthesize antibodies for the immune system. It can cause tumors in bone and soft tissues. There is no current cure, though treatment can minimize symptoms. Even with treatment, the prognosis for MM isn’t great, as the 5 year survival rate is about 44.9%. The study was very small and consisted of two female patients, ages 49 and 65, who had been diagnosed with MM 9 and 7 years prior, respectively. Scientists Just Built Technology That Can "Hear" Tumors Growing.
Genetically Engineered Algae Kills Cancer Cells Without Harming Healthy Cells. Ultrasound prises open brain's protective barrier for first time. For the first time, the barrier that protects the brain has been opened without damaging it, to deliver chemotherapy drugs to a tumour. The breakthrough could be used to treat pernicious brain diseases such as cancer, Parkinson’s and Alzheimer’s, by allowing drugs to pass into the brain. The blood-brain barrier keeps toxins in the bloodstream away from the brain. Gene editing saves girl dying from leukaemia in world first. For the first time ever, a person’s life has been saved by gene editing. One-year-old Layla was dying from leukaemia after all conventional treatments failed. “We didn’t want to give up on our daughter, though, so we asked the doctors to try anything,” her mother Lisa said in a statement released by Great Ormond Street Hospital in London, where Layla (pictured above) was treated.
How 3-D Printing Can Help To Cure Cancer. When scientists test drugs on cancer cells, they do so in the two-dimensional confines of the Petri dish. If the drug being tested works well, the next stage is to shift to the 3-D environment and see how the drug tackles 3-D tumors in animals. If that goes well, then, finally, researchers start clinical trials on humans. Technology helps personalized medicine, enabling epigenomic analysis with a mere 100 cells. A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer, is reported on today in the research journal Nature Methods. The examination of epigenomes requires mapping DNA interactions with a certain protein in the entire genome. Collaborative research team solves cancer-cell mutation mystery.
More than 500,000 people in the United States die each year of cancer-related causes. Now, emerging research has identified the mechanism behind one of the most common mutations that help cancer cells replicate limitlessly. New Genetic Tests for Breast Cancer Hold Promise. Photo. RNA is new target for anticancer drugs. Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery by University of California, Berkeley, scientists unveils a whole new set of potential targets: the RNA intermediaries between DNA and proteins.
This RNA, called messenger RNA, is a blueprint for making proteins. Messenger RNA is created in the nucleus and shuttled out into the cell cytoplasm to hook up with protein-making machinery, the ribosome. Telomeres and cancer mortality: The long and the short of it. Telomeres are short stretches of repeated nucleotides that protect the ends of chromosomes. In somatic cells, these protective sequences become shorter with each cellular replication until a critical length is reached, which can trigger cell death. In actively replicating cells such as germ cells, embryonic stem cells, and blood stem cells of the bone marrow, the enzyme telomerase replenishes these protective caps to ensure adequate replication. Blood test using sound to detect cancer could replace biopsies. Sushi parasite inspires worm test for cancer - health - 23 March 2015. Human Neural Stem Cells Restore Cognitive Functions Impaired by Chemotherapy.
New laser probe identifies brain cancer cells in real time. Revolutionary new probe zooms in on cancer cells. 'Glowing' new nanotechnology guides cancer surgery, also kills remaining malignant cells. Cancer-Detecting Nanoparticles Are Safe For Humans, Study Finds. Scientists Successfully Destroy Cancer With Nanobubbles. Goggles help surgeons ‘see’ tumours. The Promise Of A Cancer Drug Developed By Artificial Intelligence. Breakthrough Melanoma Treatment Fast Tracked By FDA.
Biologists find an early sign of cancer. Nanotechnology to fight cancer.