Virus Kills Cancer By Hitching Ride On Blood Cells. Mice 'cured' of lung cancer with gene therapy. Mice were given an antibiotic in their drinking water which activated a mutant gene known as Omomyc, and this in turn blocked the production of Myc.
Previous studies had already established this procedure for inhibiting Myc, but there were concerns it could have serious sideeffects. In the new experiment, described in the Genes and Development journal, Mice with up to 200 lung tumours were given the therapy for four weeks, followed by four-week rest periods for more than a year. After the first treatment all the mice's tumours disappeared, but 63 per cent then relapsed. Following the second treatment, only 11 per cent of the original tumours resurfaced. After eight therapy cycles, only two tumours could be identified. Dr Soucek said: "The most important finding was that there were no signs of resistance to treatment.
"It would be a good idea in humans to try and find a way to block that gene," he said. Modified Cold Sore Virus Shrinks Melanoma Tumors, Amgen Says. Polio virus engineered to kill brain tumor. DUKE (US) — A modified polio virus appears to be effective in attacking glioblastoma brain tumor cells, researchers report in an early study to establish proper dosing levels.
Tested in an ongoing phase 1 study, the treatment capitalizes on the discovery that cancer cells have an abundance of receptors that work like magnets drawing the polio virus, which then infects and kills the cells. The investigational therapy, known as PVSRIPO, uses an engineered form of the virus that is lethal to cancer cells, while harmless to normal cells. Infused directly into the patient’s tumor, the virus-based therapy also triggers the body’s immune fighters to launch an attack against the infected tumor cells. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation. Public release date: 1-Aug-2012 [ Print | E-mail | Share ] [ Close Window ] Contact: Christine A.
Somosi 216-368-6287 Case Western Reserve University Researchers at Case Western Reserve University School of Medicine have discovered a mutant form of the gene, Chk1, that when expressed in cancer cells, permanently stopped their proliferation and caused cell death without the addition of any chemotherapeutic drugs. This study illustrates an unprecedented finding, that artificially activating Chk1 alone is sufficient to kill cancer cells. "We have identified a new direction for cancer therapy and the new direction is leading us to a reduction in toxicity in cancer therapy, compared with chemotherapy or radiation therapy," said Dr. While studying the basic mechanisms for genome integrity, Dr. Cells respond to DNA damage by activating networks of signaling pathways, termed cell cycle checkpoints. Future research by Dr. This study is published in Cancer Research . Genetically engineered virus kills liver cancer.
A genetically-engineered virus tested in 30 terminally-ill liver cancer patients significantly prolonged their lives, killing tumours and inhibiting the growth of new ones, scientists reported on Sunday.
Sixteen patients given a high dose of the therapy survived for 14.1 months on average, compared to 6.7 months for the 14 who got the low dose. "For the first time in medical history we have shown that a genetically-engineered virus can improve survival of cancer patients," study co-author David Kirn told AFP. The four-week trial with the vaccine Pexa-Vec or JX-594, reported in the journal Nature Medicine, may hold promise for the treatment of advanced solid tumours. "Despite advances in cancer treatment over the past 30 years with chemotherapy and biologics, the majority of solid tumours remain incurable once they are metastatic (have spread to other organs)," the authors wrote. There was a need for the development of "more potent active immunotherapies", they noted. Trojan-horse therapy 'completely eliminates' cancer in mice.
20 December 2012Last updated at 20:14 ET By James Gallagher Health and science reporter, BBC News A hollow Trojan horse filled with soldiers was supposedly used to enter Troy An experimental "Trojan-horse" cancer therapy has completely eliminated prostate cancer in experiments on mice, according to UK researchers.
The team hid cancer killing viruses inside the immune system in order to sneak them into a tumour. Is shameless self-promotion of your science a good idea? As part of my ongoing effort to make sure that I never run out of blogging material, I subscribe to a number of quack e-mail newsletters.
In fact, sometimes I think I’ve probably overdone it. Every day, I get several notices and pleas from various wretched hives of scum and quackery, such as NaturalNews.com, Mercola.com, and various antivaccine websites. I think of it as my way of keeping my finger on the pulse of the antiscience and pseudoscience wing of medicine, but I must admit that I don’t really read them all, but they do allow me to know what the quacks are selling and what new arguments they’re coming up with without actually going to each of their websites.
I can then judge by the headlines and the blurbs included in the e-mails whether I think it’s worth it to go to the website itself and, of course, whether the topic might represent fodder for a good blog post. I will admit that not all the sites I monitor are as loony as the Health Ranger’s. Finally, apparently Prof. Two medical pioneers aim to trial a cancer-killing virus. I aim to help out. Just north of Stockholm, among the creaking Swedish ice-forests, three revolutions for 2013 are taking place. Revolution One: Two researchers at the University of Uppsala have engineered a virus that will attack cancer. Cheap, precise, with only mild, flu-like side-effects, this plucky little microbe sounds too good to be true.
Yet in peer-reviewed articles in top journals, Professor Magnus Essand and Dr Justyna Leja have repeatedly showed that Ad5[CgA-E1A-miR122]PTD views healthy tissue with disdain; it eats only tumours. Scientists discover virus that kills all grades of breast cancer ‘within seven days’ By Stephen C.
Gene therapy cures leukaemia in eight days - health - 26 March 2013. WITHIN just eight days of starting a novel gene therapy, David Aponte's "incurable" leukaemia had vanished.
For four other patients, the same happened within eight weeks, although one later died from a blood clot unrelated to the treatment, and another after relapsing. The cured trio, who were all previously diagnosed with usually fatal relapses of acute lymphoblastic leukaemia, have now been in remission for between 5 months and 2 years. Michel Sadelain of the Memorial Sloan-Kettering Cancer Center in New York, co-leader of the group that designed the trial, says that a second trial of 50 patients is being readied, and the team is looking into using the technique to treat other cancers.
The key to the new therapy is identifying a molecule unique to the surface of cancer cells, then genetically engineering a patient's immune cells to attack it.