Resurgence of Whooping Cough May Owe to Vaccine’s Inability to Prevent Infections » SPH. The startling global resurgence of pertussis, or whooping cough, in recent years can largely be attributed to the immunological failures of acellular vaccines, School of Public Health researchers argue in a new journal article.
The article, published in F1000 Research, points to the differences in mucosal immunity between whole-cell pertussis (wP) vaccines and the newer acellular pertussis (aP) vaccines, first introduced in the 1990s, as playing a pivotal role in the resurgence of the disease. “This disease is back because we didn’t really understand how our immune defenses against whooping cough worked, and did not understand how the vaccines needed to work to prevent it,” said Christopher J. Gill, associate professor of global health and lead author of the article. “Instead we layered assumptions upon assumptions, and now find ourselves in the uncomfortable position of admitting that we may made some crucial errors.
Antibiotics for whooping cough (pertussis). Antibiotics for whooping cough (pertussis) Severe tetanus in immunized patients with high anti-tetanus titers. Whooping cough resurgence due to vaccinated people not knowing they're infectious? Whooping cough has made an astonishing comeback, with 2012 seeing nearly 50,000 infections in the U.S.
(the most since 1955), and a death rate in infants three times that of the rest of the population. The dramatic resurgence has puzzled public health officials, who have pointed to the waning effectiveness of the current vaccine and growing anti-vaccine sentiment as the most likely culprits. But that might not be the whole story, suggests a new study published in BMC Medicine by Santa Fe Institute Omidyar Fellows Ben Althouse and Sam Scarpino. Their research points to a different, but related, source of the outbreak -- vaccinated people who are infectious but who do not display the symptoms of whooping cough, suggesting that the number of people transmitting without symptoms may be many times greater than those transmitting with symptoms. The problem is, the newer vaccines might not block transmission. Does this mean the current vaccine is useless? Is pertussis actually reemerging? Insights from an individual-based model.
Introduction In recent years there has been a trend towards more complex models in epidemiology.
This tendency is in part due to the increasing computational power available that allows us to run more detailed models. It is also in part due to the increasing awareness of the role of individual heterogeneity on disease dynamics. Complexity is introduced in epidemiological models in many ways. For example, hierarchical models incorporate individual - as well as population-level factors as determinants of the dynamics of transmission (Goldstein, 1995). Here, we present a spatially explicit, individual-based model for the simulation of human-parasite dynamics. Individual-based models have been successfully applied to the modeling of ecological communities (Grimm, 1999; Uchmanski et al., 1999) and microbiological populations (Kreft et al., 1998). Pertussis epidemic despite high levels of vaccination coverage with acellular pertussis vaccine. Whooping cough resurgence due to vaccinated people not knowing they're infectious? DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis - NCBI Bookshelf.
Executive Summary - Adverse Effects of Pertussis and Rubella Vaccines - NCBI Bookshelf. Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. Atypical vanishing white matter disease with microcephaly and hepatosplenomegaly provoked after diphtheria pertussis tetanus vaccination - IOS Press. Dpt documentary. Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. Genome-Wide Gene Expression Analysis of Bordetella pertussis Isolates Associated with a Resurgence in Pertussis: Elucidation of Factors Involved in the Increased Fitness of Epidemic Strains.
Acellular pertussis vaccination enhances B. parapertussis colonization — CIDD. An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade.
Despite widespread vaccination, whooping cough incidence is on the rise worldwide, making it the only vaccine-preventable disease associated with increasing deaths in the United States. Although this disease is most often attributed to Bordetella pertussis infection, it is also caused by the closely related pathogen, B. parapertussis. Acellular pertussis vaccination enhances B. parapertussis colonization — CIDD. Whooping cough resurgence due to vaccinated people not knowing they're infectious? Whooping cough has made an astonishing comeback, with 2012 seeing nearly 50,000 infections in the U.S.
(the most since 1955), and a death rate in infants three times that of the rest of the population. The dramatic resurgence has puzzled public health officials, who have pointed to the waning effectiveness of the current vaccine and growing anti-vaccine sentiment as the most likely culprits. But that might not be the whole story, suggests a new study published in BMC Medicine by Santa Fe Institute Omidyar Fellows Ben Althouse and Sam Scarpino. Their research points to a different, but related, source of the outbreak -- vaccinated people who are infectious but who do not display the symptoms of whooping cough, suggesting that the number of people transmitting without symptoms may be many times greater than those transmitting with symptoms.
The problem is, the newer vaccines might not block transmission. Why You Never Need A Tetanus Vaccine, Regardless of Your Age or Location. Back with a Vengeance: Berkeley's Head Epidemiologist On the Return of Pertussis. Professor Arthur Reingold is Head of Epidemiology at UC Berkeley’s School of Public Health California: Is whooping cough coming back?
We certainly are having a resurgence of pertussis in the United States, although it’s never gone away. It is a threat to very young infants, particularly those too young to be vaccinated or who have not yet had a complete series of the vaccines. Sources of Infant Pertussis Infection in the United States. Giving the Tdap Vaccine During Pregnancy Associated with Increased Chorioamnionitis Infection. By Paul Thomas, M.D.IntegrativePediatricsOnline.com Excerpts: The JAMA article “Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes,” November 2014 was conducted to see if the new practice of injecting pregnant moms with the Tdap has any negative outcomes.
(You can read this here.) Since this vaccine contains a very large dose of aluminum, the adverse effects I would expect to see would likely show up after infancy. Hopefully they will continue to follow these children and see if they are neurologically harmed by this neurotoxin exposure during critical brain development periods in the womb. This dangerous procedure is now routinely recommended by ACIP to be given between 27 and 35 weeks gestation. If you are a pregnant mom faced with the choice to inject your unborn baby with the Tdap (and its 170-330 micrograms of aluminum), I recommend that you wait for the safety studies. B. pertussis resurgence may be due to asymptomatic, vaccinated carriers.
The recent resurgence in cases of Bordetella pertussis, or whooping cough, may be caused by vaccinated people who are infectious but do not display symptoms, according to recent study data in BMC Medicine.
“An acellular B. pertussis vaccine which blocks symptomatic disease but not asymptomatic transmission is able to account for the observed increase in B. pertussis incidence; complicates situational awareness surrounding levels of current B. pertussis transmission; and potentially biases estimates of vaccine efficacy obtained from case data,” study researchers Benjamin M. Althouse, PhD, ScM, and Samuel V. Scarpino, PhD, both of Santa Fe Institute, wrote. The researchers analyzed the incident rate of B. pertussis in the United States and United Kingdom.
AAAAI: Kids May React to Milk Proteins in DPT Shot. Action Points Note that these studies were published as abstracts and presented at a conference.
These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.Note that in one of these studies, milk allergy reactions were observed in children receiving DPT vaccines (which may have contained traces of milk protein) and most had prior allergic reactions to cow's milk.Further note that a separate study of H1N1 and seasonal influenza vaccines in egg-allergic patients found that egg-specific IgE levels did not predict reactions to the vaccines and that reactions were rare.
SAN FRANCISCO -- Some children highly allergic to milk products should be watched with caution when receiving the diphtheria, pertussis, and tetanus (DPT) vaccine because trace milk proteins in the vaccine could trigger reactions, researchers suggested. The protein was identified as casamino acids derived from cow's milk, contained in medium used to process the vaccines. The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy. Study helps provide an understanding of rising rates of whooping cough and response to vaccination. For Immediate Release: Nov. 27, 2013 FDA study helps provide an understanding of rising rates of whooping cough and response to vaccination A new study is helping to provide a better understanding of vaccines for whooping cough, the common name for the disease pertussis.
Based on an animal model, the study conducted by the U.S. Food and Drug Administration (FDA) and published November 25, 2013, in The Proceedings of the National Academy of Sciences, shows that acellular pertussis vaccines licensed by the FDA are effective in preventing the disease among those vaccinated, but suggests that they may not prevent infection from the bacteria that causes whooping cough in those vaccinated or its spread to other people, including those who may not be vaccinated. Why Whooping Cough Is Rising Despite a New Vaccine. By Lorie ParchWebMD Feature When a new whooping cough vaccine was introduced in the late 1990s, there were hopes for a lower infection rate. But there's been a puzzling trend: a spike in new cases. More than 48,000 Americans had whooping cough in 2012 -- a 50-year high.
The disease, also known as pertussis, brings on fits of coughing that can last for weeks in adults and older kids. For babies, especially very young ones, the symptoms can be life-threatening. Straight Talk on Whooping Cough – “Pertussis vaccine is not our best vaccine, regardless of mutations” admitted Vermont Health Commissioner Harry Chen during House Testimony in April 2012.
Chen and other Health Department employees collaborated last session with medical trade organizations and their lobbyists in an effort to remove Vermont’s philosophical vaccine exemption. Despite making drastically falling vaccination rates and rising exemption rates the cornerstone of their argument for removing the philosophical exemption, data that the Vermont Department of Health had in their files told a different story. In fact, the % of schoolchildren vaccinated against whooping cough has risen steadily for years: Source: VT Immunization Surveillance Data. What is more, vaccination rates for all other vaccines continue to rise, while use of the exemption decreased in 2012 (see: VT Vaccination Rates Up, Exemptions Down in FY 2012; Health Department Report Refutes their Own Claims). Rise in pertussis cases is due to switch to acellular vaccine : Pediatric News. A marked rise in pertussis cases in recent years is a result of the accumulated effects of switching from whole-cell to acellular pertussis vaccine in the 1990s, and not declining vaccination rates, according to epidemiological modeling published online April 23 in PLOS Computational Biology.
Since the 1990s, the incidence of pertussis in the United States has risen steadily, with 2012 seeing the highest number of cases since 1955, shortly after pertussis vaccine was introduced. Infants have continued to have the highest number of reported cases, but there also has been a recent shift in disease burden from adolescents to 7- to 11-year-olds, researchers noted. Vaccination coverage, however, has remained robust for decades, at greater than 90%. Vaccinating pregnant women “halves the risk of pertussis in infants’ first four months” ~ A critique by Dr Suzanne Humphries. The latest propaganda hitting the provaccine press today involves the results of a retrospective study conducted through channels at the University of Sydney, NSW Australia. Click to see the conference poster HERE. The headlines in the press include “Whooping cough jabs for mum protect baby”, “Protecting babies against pertussis: pregnant moms and caretakers need the vaccine”, “Whooping cough vaccine advised for pregnant women”, “pertussis immunization before pregnancy halves risk.”
The title of “halving risk” comes from a medical organization called the Australasian Society for Infectious Diseases. They made a statement that is not in the poster by Dr Quinn, and stated: Whooping cough: A small drop in vaccine protection can lead to a case upsurge. In 2012 the USA saw the highest number of pertussis (whooping cough) cases since 1955. New research finds that a likely explanation for this rise in disease is a drop in the degree of vaccine protection for each vaccinated individual. A team led by Dr. Manoj Gambhir (Monash University, Melbourne, Australia), Dr. Thomas Clark (Centers for Disease Control and Prevention, Atlanta, USA), and Professor Neil Ferguson (Imperial College London, UK), worked with 60 years of pertussis disease data to determine what best explained the recent increase in the disease.
OPINION: Blame the vaccines; not the anti-vaxxers. 19 kids in Summit Co. diagnosed with whooping cough despite being up to date on vaccinations. PARK CITY, Utah — A whooping cough outbreak is causing concern in Summit County as 19 children have been diagnosed, and it’s the first time in years Park City schools have seen a case of pertussis. Officials said all of the children who have been diagnosed were vaccinated against the illness. Pertussis outbreak at Salinas school. SALINAS, Calif. — In less than one month, four students at Monterey Park School have been diagnosed with pertussis, or whooping cough. Principal Brian Hayes and school officials met with parents to offer information and answer questions. WHO Puts Kenyan Tetanus Vaccine Under Police Guard to Avoid Testing - Originally published at The Liberty Beacon If the allegations are true, this is one of the biggest stories of our time. Let’s Talk About Whooping Cough. Let’s talk about those whooping cough outbreaks, shall we?
And while we’re at it, can we talk about DTaP? Tetanus Vaccine Causes a New Disease Known as Antiphospholipid Syndrome. Skull in Pupil, by Doug Wheller, Filter applied. The Vitamin C treatment for Whooping Cough ~ Suzanne Humphries, MD. Acellular pertussis vaccination enhances B. parapertussis colonization — CIDD.
What doctors won't tell you when your baby has pertussis. - Wrapsody. I learned to skillfully manage his coughing fits by positioning him and patting him, and I was grateful he was my fifth baby, as nobody had any advice for how to manage the coughing spells.I asked everyone what I could do for my son. They all said there was nothing. And NOTHING was the wrong answer. There was something, and it wasn’t until I saw the umpteenth specialist on the evening of our second day at Maine Med before someone finally explained it to me.If only someone had taught me this simple, simple technique, I would not have held my son in my arms, unable to help him, wondering if he was going to suffocate while I watched.
Xavier napping with his big sister right after we got home from the hospital, his bulb syringe and his mama his always-present guardians. That smile reflected my relief and joy at being back with my family with a boy who was ok. FDA Reveals Shocking Statements On Vaccines. Doctors Resist Deadly Vaccine. Active Citizens, Aid, Asia-Pacific, Civil Society, Development & Aid, Editors' Choice, Featured, Headlines, Health, Human Rights, Population, Regional Categories, TerraViva Europe, TerraViva United Nations. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle.
Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. This Study Reveals Children are Being Vaccinated With Toxic Levels of Aluminium Causing Neurological Damage and Autism. CDC, FDA, Industry experts on vaccine toxicity. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Why I Choose Not to Vaccinate-Amy Goalen Whittam. Why the Press Shouldn't Dismiss Vaccine Skeptics. Adversomics: The Emerging Field of Vaccine Adverse Event Immunogenetics. A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States. Doctors Change Names of Diseases When Vaccines Do Not Work. Russell Blaylock, MD - What To Do If Force Vaccinated. Independence of CDC Scientists in Question.
Re: Journal policy on research funded by the tobacco industry. Whooping Cough III: Natural Remedies for Prevention and Treatment. Co-administration of live measles and y - PubMed Mobile. Acellular pertussis vaccination facilit - PubMed Mobile. Finally, The Truth Emerges About Whooping Cough Vaccine: OBs and. Whooping Cough Vaccine Does Not Stop Spread of Disease in Lab Animals.