Drug used to treat cancer appears to sharpen memory: Clues to keeping brain cells alive in those with Alzheimer's. Can you imagine a drug that would make it easier to learn a language, sharpen your memory and help those with dementia and Alzheimer's disease by rewiring the brain and keeping neurons alive?
New Rutgers research published in the Journal of Neuroscience found that a drug -- RGFP966 -- administered to rats made them more attuned to what they were hearing, able to retain and remember more information, and develop new connections that allowed these memories to be transmitted between brain cells. "Memory-making in neurological conditions like Alzheimer's disease is often poor or absent altogether once a person is in the advanced stages of the disease," said Kasia M. Bieszczad, lead author and assistant professor in Behavioral and Systems Neuroscience in the Department of Psychology. "This drug could rescue the ability to make new memories that are rich in detail and content, even in the worst case scenarios. " IV administration of endothelin B receptor drug reduces memory loss, oxidative stress in Alzheimer's disease. An estimated 5.3 million people in the U.S. suffer from Alzheimer's disease (AD) -- the most common form of dementia -- and roughly 473,000 people will develop the disease in 2015.
There are currently five medications approved by the Food and Drug Administration (FDA) to treat AD. However, these drugs only help mask the symptoms and do not stop the disease from progressing or treat the underlying disease. In a new study presented at the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, researchers used IRL-1620, a chemical that binds to endothelin B receptors, to treat AD in rats. Studies have shown that endothelin B receptors are important in brain development. "We used the novel approach of stimulating the endothelin B receptors by intravenous injection of IRL-1620 to prevent and repair the damage to the brain caused by Alzheimer's disease," said study co-author Seema Briyal, PhD.
Cite This Page: American Physiological Society (APS). Extra sleep fixes memory problems in flies with Alzheimer's-like condition. Many studies have linked more sleep to better memory, but new research in fruit flies demonstrates that extra sleep helps the brain overcome catastrophic neurological defects that otherwise would block memory formation, report scientists at Washington University School of Medicine in St.
Louis. Studying three groups of flies, the scientists interfered with their ability to remember by disabling a different critical memory gene in each group. In one group, the disabled gene led the flies to develop a condition with similarities to Alzheimer's disease. In another group, the disabled gene made it difficult for fly brain cells to reinforce new connections that encode memories. In the third group, the disrupted gene left the flies with too many of these connections. "Our data showed that extra sleep can handle any of these problems," said senior author Paul Shaw, PhD, associate professor of neurobiology.
The study appears online Thursday, April 23, in Current Biology. Alzheimer's breakthrough? Drug intended for diabetes appears to restore memory in Alzheimer’s brain cells. Drug used to treat cancer appears to sharpen memory: Clues to keeping brain cells alive in those with Alzheimer's. 'Smart drug' taken by one in four students really does boost performance. Dr Ruairidh Battleday said: “Modafinil can and does enhance some cognitive functions.
“For the first time, we have a cognitive enhancer that appears not to have significant detrimental cognitive, emotional, or physical side effects. “This means that it is time for a wider societal debate on how to integrate and regulate cognitive enhancement . The ethical exploration is a huge and important goal for the near future: one that both scientists, politicians, and the public need to be involved in.” Modafinil is taken by up to one in four students at British universities Photo: ALAMY A survey run by the Oxford University student newspaper The Tab showed that 26 per cent of students at the university said they had used it.
Modafinil is usually prescribed to treat sleeping disorders and has been used in the past by the US Air Force to keep pilots alert during long distance flights. DR. REUVEN FEUERSTEIN ON WHY INTELLIGENCE IS MODIFIABLE. PQ1: Belief in your fellow man makes you not accept that this individual is lost, that he will never change PQ2: Learning how to learn is the most important thing to do in a world of total change It was the young European Holocaust survivors in Israel that first inspired Professor Reuven Feuerstein to explore cognitive development, a field he has worked in for more than 60 years.
“These children went through daily and repeated trauma,” explains the 90-year-old world-renowned cognitive psychologist. “There was no need for logical thinking. What can logic play in such a situation where everything is abnormal?” Feuerstein is known for his groundbreaking work in cognitive modifiability; rejecting the idea that intelligence is fixed, he established the principle that all children can learn how to learn. Feuerstein noticed that by interacting with the children rather than administering standardized tests to them, their results improved.
BW: At first, many people didn’t trust your results.