Model Organism Antibody. Grounded in advanced technology and years of experience, Creative Biolabs is concentrating on developing recombinant antibodies from model organisms, which are in vivo models for the study of human diseases.
Model organisms provide a wealth of biological data that make them attractive to study as examples for other species, especially human, which are more difficult to study directly. For expamle, zebrafish is used as a classical developmental and embryological model for the unique combination of the optical clarity of the embryos and manipulability of embryology.
C. elegans is chose to study the nervous system. It has the larger ascendance of showing the exact course of development at the level of individual cells. Also, with close genetic relationship to human, monkeys have been central to most of the achievements of medical treatments, such as Chimpanzee, Rhesus and Cynomolgus. MHC Tetramer. Creative Biolabs is a world leading biotechnological company in research and development of agents in the realm of immunology.
With years of experience, we promise to offer best-in-class immunological reagent to meet the need of our customers. MHC Tetramers have emerged as an important tool for characterization of the specificity and phenotype of T cell immune response, useful in a large variety of disease and vaccine studies. Peptide-MHC multimers display an antigenic peptide in the MHC binding groove, functioning as a surrogate for recognition events that occur as part of the T cell interaction with antigen-presenting cell. The most prevalent form of multimer in use today consists of biotin-labeled pMHC displayed on streptavidin molecules, forming tetravalent complexes; so the common use of the term “tetramers” for this detection method.
Since first description, MHC tetramers have become widely used for quantitation of antigen-specific T cell response. Immunotoxin. Creative Biolabs is one of the first-in-class global manufacturers of immunotoxins and is professional in producing all kinds of immunotoxins.
An immunotoxin is a macromolecular drug which consists of a monoclonal antibody linked to a protein toxin.The toxin is usually a cytotoxic protein derived from a bacterial or plant protein, such as Diphtheria toxin (DT), Cholera toxin (CT), Trichosanthin (TCS), Dianthin etc.. The antibody transports the toxin in the body and selectively targets it to tumour cells by binding to a cell-surface antigen. The toxin then enters the cell and incapacitates it by irreversibly blocking an essential metabolic process. As it has little harm to normal tissues, it is vividly called "the biological missiles".
Antibody-toxin conjugates (immunotoxins) can be produced by using conventional chemical coupling techniques or recombinant DNA techniques. Hot Products: Our customer service representatives are available 24 hours a day, from Monday to Sunday. Hot Products: Hybridoma Cell Line. Humanized Antibodies. Fully human antibody. Creative Biolabs is a pioneer in fully human antibody development.
We provide a complete collection of human antibody products against full range of targets. Specifically, our experienced scientists commit to develop first in class human antibodies using well-established antibody platform on customer’s demand. Since hybridoma technology first introduced to generate mouse antibody for human treatment, antibody technology has underwent great development, and chimeric and humanized versions constituted the majority of candidates in clinical study during the 1990s. Based on hypothesis that mAbs derived from human sequences would prove to be less immunogenic than mouse, chimeric or humanized mAbs, fully human antibody is developed. The data so far indicate that human antibodies exhibit better safety, efficacy and commercial value compared to other types of antibodies, and they are a promising and rapidly growing category of targeted therapeutic agents.
Hot Products: Antibody glyco-engineering. Human IgGs have a single conserved N-glycosylation site at N297 in the CH2 domain of their constant region.
This glycosylation occurs in multiple different forms, which results in an IgG being a "collection of closely related structures" often referred as microheterogeneity. In support of our mission to enable cutting edge advances in the life sciences, we Creative Biolabs recently launched the following glyco-engineering therapeutic MAbs that describe the biological effects exerted by different glycan forms attached to N297 of an IgG Fc or Fab, and how engineering of those glycans (antibody glyco-engineering) can be used to obtain therapeutic MAb candidates with widely different biological properties:
ScFv Library. Creative Biolabs is the world-leading antibody library industry.
We can offer the customer many different choices, which satisfy most research needs. We provide many kinds of high quality premade and ready-for-use antibody libraries including: scFv, Fab VHH, original from human, mouse, rabbit, chicken, camel and llama. If none of the pre-made library meets your requirement, you are welcome to contact us, and we will be more than happy to create a custom library for you. Display technology (phage display technology and yeast display library screening technique) has become major approaches in producing highly specific antibodies for human therapy.
There are several type of antibody libraries based on display technology like immunized antibody libraries and naive antibody libraries. Our customer service representatives are available 24 hours a day, from Monday to Sunday. Antibody-toxin conjugate. Hybridoma Cell Line. Human Antibody. Glyco-Engineering Antibody. Fab Fragment Antibody. Creative Biolabs is professional in producing Fab fragment antibodies using well established methods.
We provide the most comprehensive list of Fab fragment antibodies. A Fab fragment is a special antibody which consists of four domains: VH, CH1, VL and CL1. The Fab fragment has 440-450 amino acids and its molecular weight is about 47-48 kDa. Compared with the full length antibodies, Fab fragments have some advantages. On one hand it is easy to penetrate tissues and can be generated by some simpler expression systems, such as E. coli. At present, there are three Fab fragment antibodies on the market, abciximab (ReoPro®), ranibizumab (Lucentis®) and certolizumab pegol (Cimzia®). Hot Products: Our customer service representatives are available 24 hours a day, from Monday to Sunday. Epitope-Specific Antibody. Epitope, aslo known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibody.
Anti-idiotypic Antibody. To meet the need in pre-clinical study of therapeutic antibody and vaccine development, we Creative Biolabs expand our antibody category and launch the anti-idiotypic antibody products for various applications such as pharmacokinetic study, neutralizing antibody study and immunogenicity study.
Anti-idiotypic antibody (anti-ID antibody) is a class of antibody that specifically binds to the antigen-binding site of an antibody. For each antibody molecule, the region that makes contact with an antigen is called complementary determining region (CDR) which is a unique site to be found within the variable (V) regions of an antibody heavy chain and light chain. The term idiotype refers to the whole collection of idiotopes contained in a single immunoglobulin molecule.
Idiotopes may be either in the CDR or in the framework regions (FR) of the variable domain. Antibodies Library. Chimeric Antibodies. Antibodies-based treatments have been one of the hottest therapies in recent years.
Some IgG-based biotherapeutic agents have achieved an obvious efficacy in the treatment of a wide variety of diseases, including cancers and immune disorders. Creative Biolabs can provide the most cost-effective therapeutic antibody products for both in vitro and in vivo researches, been a leading provider of antibody-based therapeutic agents. Initial therapeutic antibodies were usually murine molecules. These murine-derived antibodies have a short half-life in vivo, a limited penetration into tumour sites and inadequately recruit host effector functions.
Therefore, chimeric antibodies have gradually replaced them in therapeutic applications, being a new generation of therapeutic candidates. Chicken IgY Antibody. Creative Biolabs is a professional manufacturer of chicken IgY antibodies and provides the most cost-effective chicken IgY antibody products for a variety of in vitro and in vivo studies. Chicken IgY antibodies are egg-derived antibodies which are separated and purified from chicken egg yolk, not animal serum. Without restraining the animals, it is simply a more humane and animal-friendly way to produce antibodies. There are several distinct advantages of chicken IgY antibodies compared to mammalian IgG antibodies: Higher titres against highly-conserved mammalian proteins. Chickens are not mammals and they tend to recognize any mammalian gene product as foreign, and mount vigorous immune responses.Higher specificity compared with mammalian IgG. Therefore, chicken IgY antibodies are emerging as very useful molecular tools for research, diagnostics and therapeutics.
Hot Products: Blocking Antibody. Blocking antibody is increasingly important and has a variety of clinical and experimental uses. As a leading provider of recombinant antibody (rAb) discovery and manufacture, Creative Biolabs provides a wide range of specific blocking antibody products to help you with your research. Blocking antibody is a specific type of antibody. This type of antibody does not produce any visible reaction with the antigen when combines with it, but blocks anything else from reacting with its antigen. The function of blocking antibody is useful in clinical uses, as a blocking antibody can prevent a harmful substance from binding to the cell.
For instance, in treating allergic disorders, patients can be treated with IgG blocking antibodies that can bind to the allergen. Anti-idiotypic Antibody. Immunocytokine. Creative Biolabs is a professional manufacturer of Antibody-cytokine Fusion Proteins (ACFPs). According to the extensive experience and achievements in genetic engineering and biotechnology field, Creative Biolabs has developed a series of functional cytokine fusion antibodies, simultaneously, a growing number of new antibody-cytokine fusion proteins are under development as well.
These immunocytokine molecules were shown to have striking anti-tumor activity and may provide a useful approach to the treatment of cancer. Antibodies Library. Agonistic Antibody. In the field of therapeutic antibody development, Creative Biolabs has an increasing accumulation of experience and has already provided numerous comprehensive services and high-quality products for our clients all over the world. Recently we complete our list of agonistic antibody to be used in therapy-related and antibody-based researches. Since the first application in cancer therapy, monoclonal antibody (MAb) is shown of promising therapeutic effect. In spite of classical mechanism of actions exerted by MAb, such as neutralization, blocking, CDC, ADCC, therapeutic antibody could also act as agonists of the receptors, essentially replacing the activity of the normal ligand. The agonist activity can occur when the antibody binds the receptor in a manner that mimics the binding of the physiological ligand resulting in antibody-mediated agonism.
To date, much of the agonistic antibody in clinical and pre-clinical studies target TNF family members, such as OX40, CD27, 4-1BB and DR5. ADCC Enhanced Antibody.