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BsAbs from Creative Biolabs

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Sendai Virus vectors. The ability to manipulate the genome of the negative-strand RNA virus, including the insertion of additional non-viral genes, has led to the development of a new class of viral vectors for gene transfer.

Sendai Virus vectors

Since its isolation in Japan in 1953, SeV has been widely used as a research tool in cell biology and industry. Recombinant SeV vectors have a variety of unique properties, such as low pathogenicity, a powerful capacity for gene expression and a wide range of hosts. Due to these advantages, SeV has important application value in gene therapy as a vaccine vector. Introduction of Sendai Virus Structure.

DNA and RNA Vaccine Design. Nucleic acid vaccines were introduced decades ago but have already been widely used in infectious and malignant diseases.

DNA and RNA Vaccine Design

Nucleic acid vaccination is a technique for protecting against disease by injection with genetically engineered DNA (as a plasmid) or RNA (as mRNA). In contrast to recombinant bacteria or virus vaccines, nucleic acid vaccines consist only of DNA or RNA, which is uptake by cells and transformed into protein. In terms of the extensive experience in vaccine research, Creative Biolabs is proud to offer our clients DNA and RNA vaccine design services with the best quality and most competitive price. How Do DNA and RNA Vaccines Work? At the beginning of the 90’s, scientists discovered that plasmid DNA could induce an immune response to the plasmin coded antigen, which was one of the most important discoveries in the history of vaccine. Antibody PK/PD analysis. Creative Biolabs is specialized in conducting pharmacokinetic and pharmacodynamic (PK/PD) data analysis for antibody drug discovery, preclinical, and clinical studies.

antibody PK/PD analysis

We offer either model dependent or independent analysis services to evaluate the PK/PD of your therapeutic bispecific antibodies (BsAbs). Our analysis information will provide you with valuable insights into the design of preclinical and clinical studies of your BsAbs. Antibody drugs are expected to display a variety of desirable characteristics, such as great solubility, stability, high selectivity and specificity, long persistence in the body, and low risk for bioconversion to toxic metabolites. Antibodies have been studied in a number of disease conditions, with effects generated via a complex array of mechanisms.

One possible reason for the steady success of the therapeutic antibody development is the application of the PK/PD concepts at all stages of the drug development. Fig. 1. Antibody Absorption Fig. 2. Fig 3. 1. Orthogonal Fab BsAb. Dock and Lock (DNL) BsAb Generation Service. Controlled Fab-arm Exchange (cFAE) BsAb Generation Service. With years of experience in antibody discovery and development, Creative Biolabs is proud to offer controlled Fab-arm exchange (cFAE) bispecific antibody (BsAb) generation service.

Controlled Fab-arm Exchange (cFAE) BsAb Generation Service

Based on the advanced cFAE platform, we are dedicated to provide first-class BsAbs to support your projects in a timely and cost-effective manner. BsAbs antibody production is actively pursued for therapeutic and research antibody development. Charge Pair BsAb Generation Service. Creative Biolabs is an undisputed global leader in the bispecific antibodies (BsAbs) market.

Charge Pair BsAb Generation Service

With our professional scientists hammering at Creative Biolabs, we can offer high quality charge pair BsAb generation service. With the unique charge pair platform, our talented scientists can develop best-in-class BsAbs for diverse therapeutic applications. Triplebody. Tandem scFv. TandAb. Single-chain Triplebody. Menu Home > Products > Custom BsAbs > Single-chain Triplebody Single-chain Triplebody Single-chain triplebody (Sctb) can be regarded as tandem scFv in terms of the structure.

Single-chain Triplebody

Single-chain Triplebody. ScFv-based Bispecific Fragments. Menu Home > Products > Custom BsAbs > scFv-based Bispecific Fragments scFv-based Bispecific Fragments Scfv fragments are a class of units that are commonly used to generate BsAbs.

scFv-based Bispecific Fragments

Besides the formats widely studied, there are numerous other scFv-based bispecific fragments. scFv-CH1/CL: Two scFv fragments against different epitopes are linked to CH1/CL domain separately. Target Search Browse scFv-based Bispecific Fragments based on alphabetical listing: A B C D E F G H I K M N O P T V Ad fiber knob & CD40 Ad fiber knob & CEA Ad fiber knob & EPCAM Ad fiber knob & ITGAV albumin & IL-6R albumin & TNF Ang2 & VEGFA Welcome! To order, please email Fab-arm Exchange. Triplebody. Tandem scFv. IgG-IgG. Hybrid hybridoma. With ample experience in antibodies development and manufacture, Creative Biolabs has become an incontestable global leader in the bispecific antibodies (BsAbs) market.

Hybrid hybridoma

Based on our well-established hybrid-hybridoma technology platform, Creative Biolabs can provide first-class BsAbs production services to meet your BsAbs development goal in a timely and cost-effective manner. Hybridoma Technology Hybridoma technology has long been an outstanding and indispensable platform for producing high-quality monoclonal antibodies (mAbs). Hybridoma-derived mAbs have becoming the most rapidly expanding class of therapeutic biologics. Based on the development of mAb humanization and the production of transgenic-humanized mice, this technology has opened novel avenues for effectively producing humanized or fully human mAbs as therapeutics.

Figure 1. Duo body. Creative Biolabs provides world class bispecific IgG engineering services based on the latest antibody engineering technology platforms.

duo body

Our scientists employ the most advanced techniques to provide comprehensive bispecific antibody (BsAb) services for research and therapeutic market. The features of bispecific IgGs. Covx body. Based on the most advanced techniques and years of experience in antibody engineering field, Creative Biolabs provides custom construction and production services of various bispecific antibodies (BsAbs) and BsAb Conjugates. These diverse services can greatly facilitate your scientific and clinical research about bispecific antibody. BsAbs have the ability to bind to two different epitopes on the same or on different antigens simultaneously. Different domains of BsAbs can be fused by DNA engineering which is also the prevalent method for producing BsAbs. While a significant number of BsAbs can be derived from chemically crosslinking. By using different starting materials or fusion portions, the BsAb conjugates mainly include the following three classes:

RNA vaccine. Creative Biolabs is a leading service provider that focuses on all kinds of Vaccine Technology that include Vaccine Target Validation, Monoclonal Antibody Vaccines, Cell Based Vaccines and more.

RNA vaccine

We also provide a wide range of Vaccine Design services to meet our customers’ requirements. What Is A Vaccine? Infectious diseases cause an overwhelming number of deaths around the world and their clinical management is often hampered by the emergence of multidrug resistant strains. Therefore, prevention through vaccination is currently the best course of action to beat them. A vaccine is a biological agent that provides active acquired immunity to a particular disease. Knobs-in-holes. Based on years of experience in antibody discovery and manufacture, Creative Biolabs has established a second to none bispecific antibodies (BsAbs) generation platform. With our comprehensive platform, we are proud to offer knobs-in-holes (KIH) BsAb generation service in a timely and cost-effective manner.

Knobs-in-holes (KIH) Technology In recent years, BsAbs have rising as a potential field of research for therapies in oncology, infectious and inflammable diseases. IgG Fab. Peptide antibody. As a pioneer in the bispecific antibody (BsAbs) development and manufacture, Creative Biolabs offers many different formats of BsAbs. Based on our vast experience gained from developing hundreds of antibodies, we offer antibody-peptide conjugates with high affinity and low immunogenicity for both academic and clinical purposes. In bispecific molecules, the functional portions targeting antigens include not only antibodies but also some small drugs or peptides. In BsAb repertoire, antibody-peptide conjugates, also referred to as chemically programmed antibodies (cpAbs), are a novel class of pharmaceuticals utilizing small molecules as the navigator instead of mAb.

As therapeutic agents, mAbs and peptides have their merits. Over the past two decades, mAbs have become high successful pharmaceuticals. The antigen binding of conventional mAbs relies on the virtue of six CDRs. Figure 1. References 1. Mini body. Creative Biolabs possesses unchallenged experience in diverse bispecific antibody (BsAb) generation, such as minibody. Our platforms cover fields from recombinant protein synthesis to epitope mapping, all of which are elaborately integrated for providing an expected minibody with desired specificity and affinity. Genetic engineering is a widely used strategy to produce a variety of defined antibody fragments and novel proteins such as fusion proteins or immune-toxins.

CrossMab. Intrabody. Diabody. Bispecific T cell engager.