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The Contribution of Neanderthals to Phenotypic Variation in Modern Humans: The American Journal of Human Genetics

The Contribution of Neanderthals to Phenotypic Variation in Modern Humans: The American Journal of Human Genetics
Cell Press celebrates the achievements of James E. Rothman, Randy W. Schekman, and Neuron Editorial Board member Thomas C. Südhof, recipients of the 2013 Nobel Prize in Physiology or Medicine and congratulates Structure Editorial Board member Martin Karplus, Biophysical Journal Editorial Board member Michael Levitt, and Arieh Warshel , the recipients of the 2013 Nobel Prize in Chemistry. Read the award winners' research published in Cell Press journals FREE. Best of 2013: The conclusion of 2013 marks the third year of the Cell Picture Show and its mission of presenting the most compelling imagery in microscopy, bioscience data, and scientifically based art.

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Earliest interbreeding event between ancient human populations discovered For three years, anthropologist Alan Rogers has attempted to solve an evolutionary puzzle. His research untangles millions of years of human evolution by analyzing DNA strands from ancient human species known as hominins. Like many evolutionary geneticists, Rogers compares hominin genomes looking for genetic patterns such as mutations and shared genes. He develops statistical methods that infer the history of ancient human populations.

Netrin Netrin 1 knockout disrupts thalamocortical projections topography. From Powell et al., 2008.[1] Netrins are a class of proteins involved in axon guidance. Trends in Genetics - Properties and rates of germline mutations in humans Review 1 Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA 2 Howard Hughes Medical Institute, Seattle, WA 98195, USA Available online 16 May 2013 , How to Cite or Link Using DOI Highlights Phenology using specimens: iDigBio New Insights from Old Herbarium Specimens Contributed by Richard B. Primack (Boston University; primack@bu.edu) and Charles G. Willis (Harvard University; charleswillis@fas.harvard.edu)

Journal home : Nature Raphael Lis, Charles C. Karrasch, Michael G. Poulos, Balvir Kunar, David Redmond, Jose G. Barcia Duran, Chaitanya R. Badwe, William Schachterle, Michael Ginsberg, Jenny Xiang, Arash Rafii Tabrizi, Koji Shido, Zev Rosenwaks, Olivier Elemento, Nancy A. Speck, Jason M. Early humans in Africa may have interbred with a mysterious, extinct species – new research - Advertisement - One of the more startling discoveries arising from genomic sequencing of ancient hominin DNA is the realisation that all humans outside Africa have traces of DNA in their genomes that do not belong to our own species. The approximately six billion people on Earth whose recent ancestry is not from Africa will have inherited between 1% and 2% of their genome from our closest but now extinct relatives: the Neanderthals.

Thrombospondin 1 Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.[5][6] Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.[7] Function[edit] Past 5,000 years prolific for changes to human genome Chris Dascher / Getty Images Humans are carrying around more harmful mutations in the last 5,000 years. The human genome has been busy over the past 5,000 years. Human populations have grown exponentially, and new genetic mutations arise with each generation.

Herbarium specimens show patterns of fruiting phenology in native and invasive plant species across New England - Gallinat - 2018 - American Journal of Botany Premise of the Study Patterns of fruiting phenology in temperate ecosystems are poorly understood, despite the ecological importance of fruiting for animal nutrition and seed dispersal. Herbarium specimens represent an under-utilized resource for investigating geographical and climatic factors affecting fruiting times within species, patterns in fruiting times among species, and differences between native and non-native invasive species. Methods

Ancient humans procreated with at least four other species Fifty-thousand years ago, humans’ romantic horizons extended far beyond other boring Homo sapiens. That’s according to a July 2019 study that describes how our ancestors often mated with other species of the the Homo genus: Neanderthals, Denisovans, and two other unnamed hominids. The discovery was made after scientists used previous studies to create “mixing maps” — aka when and where mating between humans and other hominid species happened. UNC-5 Discovery of netrins[edit] The term netrin was first used in a study done in 1990 in Caenorhabditis elegans and was called UNC-6.[2] Studies performed on rodents in 1994 have determined that netrins are vital to guidance cues. The vertebrate orthologue of UNC-6, netrin-1 was determined to be a key guidance cue for axons moving toward the ventral midline in the rodent embryo spinal cord.

Mendel-GPU: haplotyping and genotype imputation on graphics processing units + Author Affiliations ↵*To whom correspondence should be addressed Received June 2, 2012. Revision received August 6, 2012. Accepted August 24, 2012. Digitization protocol for scoring reproductive phenology from herbarium specimens of seed plants - Yost - 2018 - Applications in Plant Sciences Premise of the Study Herbarium specimens provide a robust record of historical plant phenology (the timing of seasonal events such as flowering or fruiting). However, the difficulty of aggregating phenological data from specimens arises from a lack of standardized scoring methods and definitions for phenological states across the collections community. Methods and Results To address this problem, we report on a consensus reached by an iDigBio working group of curators, researchers, and data standards experts regarding an efficient scoring protocol and a data-sharing protocol for reproductive traits available from herbarium specimens of seed plants. The phenological data sets generated can be shared via Darwin Core Archives using the Extended MeasurementOrFact extension.

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