BOINC. Malariacontrol.net. Einstein@Home. Rosetta@home. Fluorescent proteins designed from scratch Congrats to all Rosetta@home volunteers who contributed to a recent report in Nature describing the design of a completely artificial fluorescent beta-barrel protein. As described by one of the main authors, Anastassia, in this forum post: The paper presents many “firsts” in computational protein design.
It is the first de novo design of the beta-barrel fold (one of the most described folds in the past 35 years, yet mysterious until now). It is also the first de novo design of a protein tailored to bind a small-molecule, which requires very high accuracy in the placement of side chains on protein backbones assembled from scratch. Additionally, we could show that these new proteins could fold and function as expected in vivo! We hope that the advances described in the paper will further enable the de novo design of many biosensors and catalysts tailored for specific applications. Rosetta Android version 4.10 released Rosetta 4.07 released ... more. Orbit@home. MilkyWay@home.
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