GetSharedSiteSession?rc=4&redirect= GetSharedSiteSession?rc=4&redirect= In summary, the coordination of DNA repair processes plays a critical role in allowing the proper development and survival of organisms.
They are responsible for preventing numerous human diseases and conditions, including cancer and aging. We envision that the further understanding of the molecular mechanisms through which the DDR operates, in combination with the elucidation of the genetic interactions between different DDR pathways and between DDR pathways and other cellular pathways, will provide therapeutic opportunities for many human diseases.
The 5' Guanosine-triphosphate Cap. Mechanism for nuclear pre-mRNA intron splicing. GetSharedSiteSession?rc=4&redirect= Figure 1 B2 RNA Associates with EZH2 and Exists as Shorter Species In Vivo (A) B2 representation (red) among SINEs, the ES cell transcriptome (RNA-seq), and the EZH2 interactome (RIP-seq).
Right pie chart depicts SINEs in the EZH2 interactome, reproduced from Zhao et al., 2010 . (B) (Top) Distribution of EZH2 RIP-seq reads around TSS (±2,000 bp) of B2 and B1 SINE elements represented as metagenes. (C) Distribution of EZH2 RIP-seq reads within B2. Guided by RNAs: X-inactivation as a model for lncRNA function. Guided by RNAs: X-inactivation as a model for lncRNA function. Integration of telomere sequences with the draft human genome sequence : Article : Nature. Nature 409, 948-951 (15 February 2001) | doi:10.1038/35057180; Received 15 November 2000; Accepted 18 December 2000 H.
C. Riethman1, Z. Xiang1, S. End to end: telomeres and ageing. Helen Blau Lab at Stanford ExtendsTelomeres; Breakthrough May Enable Increased Numbers of Cells for Experimental Testing, Also Offers Possible Avenue for Development of Anti-Aging Treatments; Work Is “Game-Changer” Says Stem Cell Authority Gerald Weissman. Will extending telomeres lead to longer, healthier lives?
Researchers have taken an important step toward answering this question by developing a new treatment used in the laboratory that extends telomeres. One of the key aspects of aging is the shortening of telomeres over time. Telomeres, which serve as protective "end caps" for chromosomes, help keep DNA healthy and functioning as it replicates.
Blau Lab. Research articles (from latest to oldest, of approximately 200) Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS (2015) Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice.
Blau Lab. We study muscular dystrophies and cardiomyoapathies using patient-derived induced pluripotent cells (iPS) We are deciphering dynamic regulatory networks controlling nuclear reprogramming We are developing molecular approaches to rejuvenate cells to combat aging We are developing ways to extend telomeres transiently and safely to augment cell proliferative capacity and treat disease We use interdisciplinary approaches — biomaterials, imaging, single cell proteomics, genomics and tracking We use single cell proteomic and genomic technologies to study mechanisms governing muscle stem cell fate and regeneration.
Telomere extension turns back aging clock in cultured human cells, study finds. A paper describing the research was published today in the FASEB Journal.
Blau, who also holds the Donald E. and Delia B. Baxter Professorship, is the senior author. Postdoctoral scholar John Ramunas, PhD, of Stanford shares lead authorship with Eduard Yakubov, PhD, of the Houston Methodist Research Institute.