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Diabetes - Prediabetes

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Insulog – Launch. Please note this story is under embargo until Wednesday, December 7, 2016 at 8:00am PST Tel Aviv, Israel, December 7, 2016 – Insulog, a device that connects with all major disposable insulin pen brands to display most recent injection data, paired with its app to display entire injection history in order to better manage diabetes, is today announcing the unveiling of its smart, connected insulin tracker.

Insulog – Launch

The device will soon be made available via Indiegogo, to bring its technology to the masses. Diabetes can be a difficult condition to manage, and constantly sticking yourself with needles, and remembering what you ate isn’t easy. Extranuclear Actions of the Androgen Receptor Enhance Glucose Stimulated Insulin Secretion in the Male. Metformin The hidden chronicles of a magic drug. Development of a simple tool to predict the risk of postpartum diabetes in women with gestational diabetes mellitus.

U.S. Task Force advises blood sugar tests for overweight adults. A1C: Does One Size Fit All? Diabetes Risk Lower With Nighttime BP Meds. Dosing antihypertensives before sleep instead of upon waking lowered risk of incident diabetes in a randomized trial.

Diabetes Risk Lower With Nighttime BP Meds

And, in fact, sleeping BP -- but not daytime or 48-hour ambulatory BP -- was found to be a significant predictor of new-onset diabetes and may be a novel target for prevention, a research team led by Ramón Hermida, PhD, of the University of Vigo, Spain, and colleagues reported in Diabetologia. During a median follow-up of 5.9 years, 171 study participants developed diabetes. Incidence of new-onset diabetes was significantly lower in the bedtime group (4.8%) versus the daytime group (12%) (P<0.001).

After adjusting for factors including fasting glucose, waist circumference, and chronic kidney disease, the investigators found the bedtime group was 57% less likely to develop diabetes (HR 0.43; 95% CI 0.31-0.61; P<0.001). Gestational Diabetes Tied to Later Heart Disease. Action Points A complication during pregnancy was associated with 1.6 to 4-fold increased risk of cardiovascular disease (CVD)-related death decades later, and various combinations of two or more pregnancy complications increased the risk by up to 7-fold.The highest risk events were glycosuria and early pre-eclampsia but, fortunately, they were the least common events with fewer than 0.5% and 0.3% of births, respectively.

Gestational Diabetes Tied to Later Heart Disease

Sustaining a complication during pregnancy was associated with a 1.6- to 4-fold increase in the risk of cardiovascular disease (CVD)-related death decades later, with glycosuria and early pre-eclampsia incurring the steepest risk, researchers reported. Diabetes Drug Cuts Cardiovascular Event Risk in High-Risk Patients. September 22, 2015 Empagliflozin-treated patients had a 38% reduction in the relative risk of cardiovascular death versus placebo recipients.

Diabetes Drug Cuts Cardiovascular Event Risk in High-Risk Patients

The diabetes drug empagliflozin cuts the risk of cardiovascular events in high-risk type 2 diabetes patients, a new study finds. The possible mechanisms are “multidimensional,” according to investigators, and might involve changes in arterial stiffness, cardiac function, and cardiac oxygen demand, as well as cardiorenal effects and reductions in albuminuria and uric acid. The drug is also believed to have modest effects on weight, blood pressure, and belly fat, along with lowering blood sugar.

Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial. Aims/hypothesis We investigated whether therapy with the entire daily dose of ≥1 hypertension medications at bedtime exerts greater reduction in the risk of new-onset diabetes than therapy with all medications upon awakening.

Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial

Methods. Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial. Obesity at Pregnancy Linked to Diabetes Later. Action Points Note that this study was published as an abstract and presented at a conference.

Obesity at Pregnancy Linked to Diabetes Later

These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.Note that this observational study found that women who were overweight at the time of their first pregnancy had a substantially increased risk of diabetes in the following 10-17 years. STOCKHOLM -- Women who are overweight or obese at the time of their first pregnancy are more likely to receive a diagnosis of diabetes a decade down the road, researchers reported here.

Medscape Log In. Effect of Bariatric Surgery vs Medical Treatment on Type 2 Diabetes in Patients With Body Mass Index Lower Than 35:  Five-Year Outcomes. Toddler with type 2 diabetes highlights global obesity epidemic. Why Asian Americans have diabetes but don’t know it. For the U.S. population overall, the average BMI is just under 29, according to researchers.

Why Asian Americans have diabetes but don’t know it

A BMI of 25 to 30 is considered overweight, and a BMI of 30 or greater is considered obese. But Asian Americans often develop diabetes at a lower BMI. The American Diabetes Association recommends Asian Americans get tested for diabetes at a BMI of 23 or higher, a lower threshold than the general population. Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012. Diabetes, Other Risk Factors Significantly Increase Heart Attack Risk in Young Women.

Cardiovascular diseases (CVDs) cause more than 52% of all deaths in females, according to the World Health Organization (WHO), and myocardial infarction (MI) incidence is increasing in the younger population.

Diabetes, Other Risk Factors Significantly Increase Heart Attack Risk in Young Women

Up to 1% of all heart attacks take place in young females. A team from the Institute of Cardiology in Poland aimed to identify the effect of risk factors on MI incidence and uncover how age plays a role as well. The researchers presented the study at the European Society of Cardiology (ESC) Congress in London, UK. “Cardiovascular diseases (CVDs) affect mainly the elderly, but for many years an increase in incidence has been observed in young people as well, regardless of gender,” one of the authors Hanna Szwed, MD, PhD, said in a news release. A total of 7.386 females were included in the study – 1,941 with MI history (ages 21 to 45), 4,275 with MI history (ages 63 to 64), and 1,170 health controls (ages 45 and younger). Early diabetes detection tied to fewer heart problems. Medscape Log In. VCU researchers looks for answers to obesity-diabetes trajectory - Health. If you are one of the millions of overweight Americans trying to slim down, fat is fat when you’re trying to squeeze into a pair of jeans or climb a flight of stairs without huffing and puffing.

VCU researchers looks for answers to obesity-diabetes trajectory - Health

But to researchers all fat is not equal — so-called brown fat helps regulate body temperature and burns more energy than white fat. People have both types of fat but usually a lot more white fat. It’s the white fat that accumulates around the belly and that’s associated with fat consequences, such as increased risk for diabetes. Obesity and diabetes researchers may have landed on a way to make white fat behave more like metabolically active brown fat: cold temperatures. “Just by changing the thermostat from 74 to 68 degrees Fahrenheit ... that was sufficient to increase the energy expenditure by about 6 percent,” said Dr. “What we demonstrated is that with just minimal change in terms of temperature overnight was sufficient to increase the amount of brown fat,” Celi said.

Lessons in Diabetes Care from Around the World. Type 2 diabetes (diabetes mellitus) is one of the most common chronic diseases worldwide and requires coordinated care and active patient engagement for effective management.

Lessons in Diabetes Care from Around the World

The disease affects 380 million adults around the world or 8.3% of the global adult population. The prevalence of diabetes around the world is projected to continue to rise with increased globalization and the resulting behavioral changes, nutritional shifts, and aging populations. Around the world, a range of programs are attempting to confront this growing trend by implementing care transformations that support prevention and disease management.

At the same time, health systems have been under mounting fiscal pressure to reduce healthcare costs. Yet, many countries, including the U.S., still struggle to support and sustain effective diabetes programs. Four eggs a week 'can reduce risk of diabetes' The study, published in the American Journal of Clinical Nutrition, said that eggs contained many nutrients that could effect glucose metabolism and low-grade inflammation. However, consumption of more than four eggs did not bring any significant additional benefits. And researchers warned that those who already have type 2 diabetes should not increase their egg intake, as they appeared to increase heart disease in those who had already been diagnosed with the condition. The scientists studied the eating and lifestyle habits of those who took part in the Kuopio Ischaemic Heart Disease Risk Factor Study between 1984 and 1989.

Type 2 Diabetes Slideshow: Symptoms, Diagnosis, and Treatment of Type 2 Diabetes. Diabetes Newsletter Find tips and advances in treatment. Reviewed by Brunilda Nazario, MD on March 04, 2014 Sources: Link between type 2 diabetes and Alzheimer’s disease: from epide. Authors Li XH, Song DL, Leng SX Published Date March 2015 Volume 2015:10 Pages 549—560 DOI Received 10 September 2014, Accepted 14 November 2014, Published 10 March 2015 Approved for publication by Dr Richard Walker Video abstract presented by Dalin Song. Diabetic Charts A Year's Worth Of His Health Data. Genetic support for insulin system role in growth hormone response. MedwireNews: Genetic determinants of insulin sensitivity are positively related to spontaneous growth and response to growth hormone (GH) treatment in children born small for gestational age (SGA), researchers have found. A genetic score based on single nucleotide polymorphisms known to affect insulin sensitivity was associated with spontaneous post-natal weight gain, and with height velocity, weight and change in insulin-like growth factor (IGF)-I levels in children receiving GH therapy, report Rikke Beck Jensen (University of Copenhagen, Denmark) and co-workers.

However, when they added the genetic insulin sensitivity score to the Ranke growth prediction model for SGA children, it accounted for only an additional 5% of the variability in GH response, increasing the variability accounted for from 17% to 22%, which the team says “is insufficient for such scores to have clinical utility in individual treatment prediction.”

Precision medicine to prevent diabetes? Researchers develop personalized way to steer prevention efforts. Medscape Log In. Study Describes Epigenetic Shifts Linking Obesity, Diabetes.

Type II Diabetes

CDC Media Relations Press Release October 22, 2010. Diabetes Risk Falls When Prediabetes Resolves. Exercise Hormone May Fight Obesity and Diabetes NYTimes. Feig (2011 Dia Care) Metformin use in pregnant women. Garber (2011 Dia Care) Long acting GLP 1 receptor agonists review of efficacy and tolerability.

Glycosylated Hemoglobin Associated with Diabetes Risk. Hu (2011 Dia Care) Globalization of Diabetes.