200,000 Years Ago Something Happened that Changed Humans Gentically. 9996.full. Induced pluripotent stem cells - Rudolf Jaenisch. Genome Editing with CRISPR-Cas9. Easy DNA Editing Will Remake the World. Buckle Up. Any gene typically has just a 50–50 chance of getting passed on.
Either the offspring gets a copy from Mom or a copy from Dad. But in 1957 biologists found exceptions to that rule, genes that literally manipulated cell division and forced themselves into a larger number of offspring than chance alone would have allowed. A decade ago, an evolutionary geneticist named Austin Burt proposed a sneaky way to use these “selfish genes.” He suggested tethering one to a separate gene—one that you wanted to propagate through an entire population. If it worked, you'd be able to drive the gene into every individual in a given area.
Push those modifications through with a gene drive and the normal mosquitoes wouldn't stand a chance. Emmanuelle Charpentier did early work on Crispr. Kevin Esvelt, the evolutionary engineer who initiated the project, knows how serious this work is. Esvelt talked all this over with his adviser—Church, who also worked with Zhang. These problems don't end with mosquitoes.
Scientists turn mouse skin cells into egg cells and make baby mice. Scientists have successfully turned mouse skin cells into egg cells and used them to create viable offspring without the use of actual eggs for the first time.
Just a small percentage of the mouse cells created in the lab led to live births, researchers reported Monday in Nature, but the healthy pups that resulted from these sci-fi pregnancies provide hope that similar techniques might one day aid human reproduction. In theory, techniques like these could even allow two biological men to co-parent a child without the use of an egg donor. The new study is the culmination of years of incremental progress: Researchers began by coaxing cells from female mouse tails into pluripotent stem cells using a technique that won Shinya Yamanaka a Nobel Prize in 2007. Pluripotent cells have the potential to divide indefinitely and become any kind of body tissue, and they are the type of cells found in embryos. The next step was to turn those pliable cells into sex cells. Pigs and Humans share 112 DNA mutations, say scientists. London: Scientists have sequenced the genome of the pig, showing the swine and humans share 112 DNA mutations linked to a range of disease including Parkinson’s and Alzheimer’s, which may be useful in fighting diseases.
Researchers, who undertook the largest ever study of the pig genome, found that swine are adaptable, easy to seduce with food and susceptible to domestication – much like humans. Representative image. Reuters Insights into the genetic code of pigs reveal the swine and its cousin the wild boar have much in common with humans. The new analysis also supports the use of the pig in studies of human diseases. “In total, we found 112 positions where the porcine protein has the same amino acid that is implicated in a disease in humans,” the researchers said. “We identified many more gene variants implicated in human disease, further supporting the pig as a valuable biomedical model,” Professor Martien Groenen, a principal investigator on the study, said.
Tags: didyouknow, Gnome, Pig. Only 8.2 % of Human DNA is Functional, Say Genetic Researchers. According to a group of genetic scientists led by Dr Gerton Lunter of the University of Oxford’s Wellcome Trust Centre for Human Genetics, only 8.2 percent of human genome is likely to be doing something important.
Illustration of a DNA molecule. Image credit: Christoph Bock, Max Planck Institute for Informatics / CC BY-SA 3.0. This figure is very different from one given in 2012 by researchers from the Encyclopedia of DNA Elements (ENCODE) project, who stated that about 80 percent of human DNA has some biochemical function. That claim has been controversial, with researchers arguing that the biochemical definition of function was too broad – that just because an activity on DNA occurs, it does not necessarily have a consequence; for functionality you need to demonstrate that an activity matters. To reach the new figure, Dr Lunter and his colleagues took advantage of the ability of evolution to discern which activities matter and which do not.