Predicting Future Morphological Changes of Lesions from Radiotracer Uptake in 18F-FDG-PET Images. Abstract We introduce a novel computational framework to enable automated identification of texture and shape features of lesions on 18F-FDG-PET images through a graph-based image segmentation method. The proposed framework predicts future morphological changes of lesions with high accuracy. The presented methodology has several benefits over conventional qualitative and semi-quantitative methods, due to its fully quantitative nature and high accuracy in each step of (i) detection, (ii) segmentation, and (iii) feature extraction.
To evaluate our proposed computational framework, thirty patients received 2 18F-FDG-PET scans (60 scans total), at two different time points. Citation: Bagci U, Yao J, Miller-Jaster K, Chen X, Mollura DJ (2013) Predicting Future Morphological Changes of Lesions from Radiotracer Uptake in 18F-FDG-PET Images. Editor: Chin-Tu Chen, The University of Chicago, United States of America Competing interests: The authors have declared that no competing interests exist. Coconut oilandalzheimerswap fconference11_09. Introduction to Drawing Regions of Interest (ROIs) Introduction to ROI Drawing There are two general reasons to draw a Region-of-Interest (ROI) on neuroimaging data: (i) to examine the morphological properties of an anatomic structure, and (ii) to extract data for a specific structure from a corresponding functional data set.
Morphologic properties include things such as volume, length dimensions, and center-of-mass location, which can be compared between several different image volumes. Functional image data usually have poorly defined anatomic boundaries compared to a high-resolution T1-weighted MRI scan, so frequently a ROI is drawn on a homogenous area of an MRI image, and the corresponding voxels are extracted from a coregistered functional (e.g. PET, fMRI) image. A ROI performs two major functions: it defines a specific shape which can be examined for morphological reasons, and it specifies voxels within an image volume which are of interest.
The primary form of a ROI is as a "mask". BrainMaker uses both of these approaches. Alzheimer's & Dementia Testing Advances | Research Center. Biomarkers for earlier detection Current diagnosis of Alzheimer's relies largely on documenting mental decline. We now know that Alzheimer's has already caused severe brain damage in individuals who are diagnosed in this way. Researchers hope to discover an easy and accurate way to detect Alzheimer's before these devastating symptoms begin. Experts believe that biomarkers (short for "biological markers") offer one of the most promising paths. A biomarker is something that can be measured to accurately and reliably indicate the presence of disease. Several potential biomarkers are being studied for their ability to indicate early stages of Alzheimer's disease.
Before a biomarker can be used in medical clinics, it must be validated, in which multiple studies in large groups of people establish that it accurately and reliable indicates the presence of disease. Back to top Brain Imaging/ neuroimaging Catalyst to progress Cerebrospinal fluid (CSF) proteins Sign up for our weekly e-newsletter. Fundamentals of Gerontology:Counseling the Elderly and their Families. Screening for Dementia The assessment batteries typically used to detect organic disorders in younger adults (e.g., the Halstead-Reitan, the Wechsler Memory Scale--Revised, and the WAIS-R) now have norms that extend into the young-old years, with some norms available for the old-old on some tests (see, for example, LaRue, 1992; Storandt & VandenBos, 1994).
In addition, these batteries are typically better with the assessment of acute, focal lesions than with chronic, diffuse disorder (see Matarazzo, 1972; Reitan, 1975). The best available tests tend to be the dementia screening inventories like the Folstein Mini-Mental State Examinatio (MMSE; Folstein et al, 1974; 1985). These screening devices are limited and have fairly high error rates, especially with low education older adults, very intelligent older adults, and people with psychological disorders (see Folstein et al, 1985).
For example, an inverse relationship was found between MMSE scores and age. Memory & Brain Scan Tests Identified for Best Predicting Alzheimer’s. New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer’s disease. Memory and brain scan tests were performed on 85 people with mild cognitive impairment (MCI) who were part of a larger study called the Alzheimer’s Disease Neuroimaging Initiative. The tests included an episodic memory test, in which a participant must correctly recall a list of words. Blood tests were given to measure which form of the APOE gene people had, since one form of the gene is associated with Alzheimer’s disease.
MRI brain scans were also used to measure the size of a participant’s hippocampus, the part of the brain responsible for learning and memory. Proteins thought to play a role in Alzheimer’s disease, called tau or beta-amyloid, were also measured. Image: PET scan of brain activity, normal brain above and Alzheimer’s brain below.
References: 1. Principe du PetScan. MPs warn of dementia delays. A PET scan showing a normal brain (left) compared to that of an Alzheimer's patient Patients with dementia are facing huge delays in their diagnosis and treatment according to a group of MPs and peers. A report by the All-Party Parliamentary Group (APPG) on the barriers to tackling diseases such as Alzheimer’s, found that fewer than half of sufferers have a formal diagnosis. Dementia is thought to affect around 800,000 people in the UK and is on the increase, with the cost to society estimated at £23 billion per year. Yet there are huge variations in access to treatment: in Belfast, for example, 70% of people receive a diagnosis, but in parts of Wales it is less than 40 per cent.
The APPG’s ‘Unlocking diagnosis: the key to improving the lives of people with dementia’ found that a lack of public and GP awareness and the variability of memory services, were major factors in these variations. Government keen to tackle dementia Adam Hill. PET scan - National Library of Medicine - PubMed Health. 18F-FDG PET/CT Imaging In Oncology. More Projects | NRG Projects | Neuroinformatics Research Group.
Aside from our large funded projects, NRG developers are always busy working on many smaller projects, enhancements, and activities. Some of these are stand alone activities, but many are small pieces of cutting-edge development which can contribute to or lay the groundwork for larger projects like the CNDA and the Human Connectome Project. The Charles F. and Joanne Knight Alzheimer’s Disease Research Center (ADRC) has been a center of research into the causes and treatments of Alzheimer’s disease for more than thirty years. As this field of research has adapted to emerging imaging technologies, NRG has supported the ADRC, making important enhancements to CNDA to support ADRC-specific research and workflows.
The multitude of MRI-based brain research projects around the globe is providing current and future researchers with a wealth of data to analyze. Related: the DIAN Therapeutic Trials Unit (DIAN-TU) project was spawned from this original DIAN project. Diffuse Optical Tomography Dr. What is a PET scan? How does a PET scan work? - Medical News Today. A PET scan uses radiation, or nuclear medicine imaging, to produce 3-dimensional, color images of the functional processes within the human body. PET stands for positron emission tomography. The machine detects pairs of gamma rays that are emitted indirectly by a tracer (positron-emitting radionuclide), which is placed in the body on a biologically active molecule. The images are reconstructed by computer analysis.
Modern machines often use a CT X-ray scan which is performed on a patient at the same time in the same machine. PET scans can be used to diagnose a health condition, as well as for finding out how an existing condition is developing. PET scans are often used to see how effective an ongoing treatment is. You will also see introductions at the end of some sections to any recent developments that have been covered by MNT's news stories. Fast facts on PET scans Here are some key points about PET scans. How does a PET scan work? Radiotracer Detecting positrons The image Epilepsy Cancer.