Ankylosing Spondylitis Linked To A Specific Gene | Doctor Tipster. Genetic testing for ankylosing spondylitis is getting closer to a successful discovery regarding the link of a specific gene to inflammatory rheumatic disease. The researchers conducted a study focusing on the genetic involvement in the development of the disease. It has been found out that a natural variation of enzymes in the immune system can make a person more susceptible to having an inflammatory rheumatic disease called ankylosing spondylitis. What is ankylosing spondylitis An ankylosing spondylitis is a type of chronic inflammatory arthritis affecting the joints in the spine. The genetic involvement in ankylosing spondylitis Clinical researchers believe that the disease is due to the combination of genetic and environmental causes. Genetic testing underway A current genetic testing is getting closer to finding the association of certain types of genes to ankylosing spondylitis, more specifically the ERAP1.
The ERAP gene Complementary Reading Like this: Like Loading... Cosentyx may be effective in treatment of ankylosing spondylitis. Cosentyx was shown to sustain improvements in patients with ankylosing spondylitis during the course of 1 year, according to data from the MEASURE2 study presented at the European League Against Rheumatism Annual European Congress of Rheumatology. Researchers studied 219 adults with active ankylosing spondylitis (AS) who were randomly assigned to receive either 150 mg or 75 mg of Cosentyx (secukinumab, Novartis) or placebo at baseline, each week through week 3 and again every 4 weeks from week 4 and on. Patients initially randomly assigned to placebo were re-randomized to 75 mg or 150 mg secukinumab at week 16 and every 4 weeks thereafter. Patient-reported outcomes were measured using SF-36, AS Quality of Life (ASQoL), EuroQoL (EQ-5D), Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-Fatigue) and Work Productivity and Activity Impairment – General Health (WPAI-GH) every 4 weeks.
Patients were evaluated at week 16 and week 52. Reference: Deodhar A, et al. Paper #AB0736. Early Infections Linked to Later Spine Disease. ROME -- Low birth weight and childhood infections were associated with the later development of ankylosing spondylitis, according to a study presented here. The odds ratio for being diagnosed with ankylosing spondylitis was 1.3 (95% CI 1.1-1.6) for individuals whose birth weight was below 3,000 g compared with those of normal birth weight, reported Ulf Lindstrom, PhD, of the Sahlgrenska Academy in Gothenburg, Sweden. In addition, individuals who were diagnosed with ankylosing spondylitis more often had older siblings (63% versus 58%, OR 1.3, 95% CI 1.1-1.4), which is often considered a proxy for greater exposure to childhood infections, Lindstrom said in a press conference at the annual meeting of the European League Against Rheumatism.
Genetic factors have been strongly linked with ankylosing spondylitis, particularly the HLA-B27 genotype. However, twin studies have suggested that there also are likely to be environmental factors involved, as has been seen in other diseases. Inspiratory muscle training improves lung function in ankylosing spondylitis. The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) showed that inspiratory muscle training (IMT) significantly improves lung strength and efficiency in patients with ankylosing spondylitis (AS), a condition often associated with breathing difficulties.
These findings demonstrate that just eight weeks of IMT provide greater improvements in lung function than conventional treatment options. AS is a painful and progressive form of arthritis caused by chronic inflammation of the joints in the spine. AS significantly impairs lung function, reducing pulmonary muscle strength and endurance in up to 40%-80% of patients. Prevalence of AS varies globally, and is estimated at 23.8 per 10,000 in Europe and 31.9 per 10,000 in North America. Inspiratory muscle training is a course of therapy consisting of a series of breathing exercises to strengthen the bodies' pulmonary muscles. Study shows that ankylosing spondylitis can be predicted by low birth weight. Published on June 12, 2015 at 1:55 AM The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) Press Conference showed that a diagnosis of ankylosing spondylitis (AS) can be predicted by low birth weight, having older siblings and hospitalisation for infection between the ages of 5-16 years.
These data suggest that these factors play an important role in the pathogenesis of the disease. AS is a painful and progressive form of arthritis caused by chronic inflammation of the joints in the spine. Prevalence of AS varies globally, and is estimated at 23.8 per 10,000 in Europe and 31.9 per 10,000 in North America. The cause of AS is unknown. Although AS is strongly associated with the genotype HLA-B27, not everyone testing positive for the marker goes on to develop the disease. Data from several Swedish national registers were used for this study, with five matched controls (sex, age, county) identified for each case of AS.