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Medscape: Medscape Access. TBL. Title: B-cell-targeted therapy in systemic vasculitis.Author: Lally L; Spiera RJournal: Curr Opin Rheumatol; 2016 Jan; 28(1):15-20.

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Light may be effective treatment for chronic pain, study says. MONTREAL, April 20 (UPI) -- With opioid dependency and misuse issues continuing to grow nationwide, researchers are looking to non-opioid options for pain control -- including light.

Light may be effective treatment for chronic pain, study says

Researchers at McGill University in Canada reduced pain in mice by shining light on the affected area using a technique called optogenetics, according to a study published in the journal eNeuro. 'Pain paradox' may lead to more effective pain treatment. LEEDS, England, July 28 (UPI) -- A substance that activates pain in the central nervous system was found by researchers to also reduce pain in the peripheral nervous system, a finding researchers say is surprising but could help improve methods of pain management.

'Pain paradox' may lead to more effective pain treatment

Researchers in England and China discovered the paradox of Substance P, which they say explains why some pain control drugs work in the lab but not in clinical trials, according to a recent study published in the journal Antioxidants and Redox Signaling. Substance P is a peptide that in the central nervious system excites nerve cells and promotes pain responses, but in the peripheral nervous system acts like a natural painkiller. Compound may kill pain like opioids, without overdose risk.

WASHINGTON, Aug. 18 (UPI) -- Opioid painkillers allow doctors to perform a range of procedures knowing they can eliminate pain during recovery, but the drugs pose a risk to health because they suppress breathing and are highly addictive.

Compound may kill pain like opioids, without overdose risk

Researchers at four universities designed a compound that successfully killed pain while appearing not to suppress breathing or induce addictive behavior in mice, suggesting it has potential for safer use with humans, according to a study published in the journal Nature. Morphine has been used in medicine since the 19th century when chemists purified it for use in treatment. The main drawbacks of the drug, and others derived from the opium poppy such as oxycodone, codeine and fentanyl, come from side effects.

Opioid drugs bind to the mu opioid receptor in the brain, taking advantage of a chemical pathway to kill pain. When they do this, though, the chemicals also activate another pathway suppressing respiration. "Morphine transformed medicine," Dr. An Error Occurred Setting Your User Cookie. An Error Occurred Setting Your User Cookie. Targeting Brain Cells to Alleviate Neuropathic Pain – Neuroscience News. Infections and Antibiotic Use Linked to Manic Episodes in People With Serious Mental Illness – Neuroscience News.

Summary: A new study appears to add to the growing evidence that the immune system may play a vital role in some psychiatric disorders.

Infections and Antibiotic Use Linked to Manic Episodes in People With Serious Mental Illness – Neuroscience News

Source: Johns Hopkins Medicine. In research using patient medical records, investigators from Johns Hopkins and Sheppard Pratt Health System report that people with serious mental disorders who were hospitalized for mania were more likely to be on antibiotics to treat active infections than a group of people without a mental disorder. Although the researchers caution that their study does not suggest cause and effect, they note that it does suggest that an infection, use of antibiotics or other factors that change the body’s natural collection of gut and other bacteria may individually or collectively contribute to behavioral changes in some people with mental disorders. Yolken says his team’s study grew out of an interest in long-observed connections among infections, the microbiome and symptoms of mental illness. Menstrual Headache And Estrogen: Female Hormone Drops More Rapidly In Migraine Sufferers : HEALTH : Tech Times.

Analysis of first morning urine samples showed link between the female sex hormone and migraine.

Menstrual Headache And Estrogen: Female Hormone Drops More Rapidly In Migraine Sufferers : HEALTH : Tech Times

Levels of estrogen drop more rapidly in women with history of migraine headaches days before menstruation. ( Foundry Co | Pixabay ) Migraine more often occurs in women than in men. Medscape Access. Cells carry 'memory' of injury, which could reveal why chronic pain persists. A new study from King's College London offers clues as to why chronic pain can persist, even when the injury that caused it has gone.

Cells carry 'memory' of injury, which could reveal why chronic pain persists

Although still in its infancy, this research could explain how small and seemingly innocuous injuries leave molecular 'footprints' which add up to more lasting damage, and ultimately chronic pain. All of us are likely to know someone who suffers from persistent pain - it is a very common condition, which can be caused by sports injuries, various diseases and the process of ageing. Treatment options are limited and doctors are often unable to offer anything more than partial relief with painkillers, leaving their patients resigned to suffering. Text - S.524 - 114th Congress (2015-2016): Comprehensive Addiction and Recovery Act of 2016.

To authorize the Attorney General to award grants to address the national epidemics of prescription opioid abuse and heroin use.

Text - S.524 - 114th Congress (2015-2016): Comprehensive Addiction and Recovery Act of 2016

Be it enacted by the Senate and House of Representatives of the United States of America in Congress assembled, SECTION 1. Short title; table of contents. (a) Short title. —This Act may be cited as the “Comprehensive Addiction and Recovery Act of 2016”. (b) Table of contents. Sec. 1. Scientists demonstrate that electrical stimulation of deep brain structures under the cortex could help ease chronic pain - UTA News Center.

Yuan Bo Peng, UTA psychology professor Abuse of prescription opioid medicines used to treat chronic pain has reached epidemic proportions, so much that the White House has announced new efforts to combat addiction and prevent the thousands of overdose-related deaths reported in the U.S. each year.

scientists demonstrate that electrical stimulation of deep brain structures under the cortex could help ease chronic pain - UTA News Center

But a University of Texas at Arlington research team has been working on an alternative solution: electrical stimulation of a deep, middle brain structure that blocks pain signals at the spinal cord level without drug intervention. The process also triggers the release of beneficial dopamine, which may reduce the emotional distress associated with long-term pain, researchers said. “This is the first study to use a wireless electrical device to alleviate pain by directly stimulating the ventral tegmental area of the brain,” said Yuan Bo Peng, UTA psychology professor. J. Peng and J. 'You want a description of hell?' OxyContin's 12-hour problem #InvestigatingOxy - Los Angeles Times. The drugmaker Purdue Pharma launched OxyContin two decades ago with a bold marketing claim: One dose relieves pain for 12 hours, more than twice as long as generic medications.

'You want a description of hell?' OxyContin's 12-hour problem #InvestigatingOxy - Los Angeles Times

Patients would no longer have to wake up in the middle of the night to take their pills, Purdue told doctors. One OxyContin tablet in the morning and one before bed would provide “smooth and sustained pain control all day and all night.” On the strength of that promise, OxyContin became America’s bestselling painkiller, and Purdue reaped $31 billion in revenue. But OxyContin’s stunning success masked a fundamental problem: The drug wears off hours early in many people, a Los Angeles Times investigation found. Scientists demonstrate that electrical stimulation of deep brain structures under the cortex could help ease chronic pain - UTA News Center. Medscape Access. Draft CDC Guideline for Prescribing Opioids for Chronic Pain. The Problem Existing guidelines vary in recommendations, and primary care providers say they receive insufficient training in prescribing opioid pain relievers.

It is important that patients receive appropriate pain treatment, and that the benefits and risks of treatment options are carefully considered. 259 million In 2012, health care providers wrote 259 million prescriptions for opioid pain relievers – enough for every American adult to have a bottle of pills.1 300% increase Prescription opioid sales in the United States have increased by 300% since 1999,2 but there has not been an overall change in the amount of pain Americans report.3,4 2 million. Orthofeet Diabetic Footwear, Comfort Shoes, Orthotics & More. Medscape Log In. Herbal Options for Managing Adrenal Fatigue. Think of adrenal fatigueas the "waiting room" for type-2 diabetes, hypothyroidism and heart attack. As a disease classification, it hangs out there with other "pre-" conditions like"pre-diabetes" and "pre-hypertension," and is a strong indicator of which direction a patient's health is headed; namely, down.

The exhaustion of the body's ability to react to the signals from the brain and pituitary gland inevitably contributes to disease states like type-2 diabetes, hypertension, and hypothyroidism. Because adrenal fatigue affects a cluster of body systems, treatment is incomplete if it just targets individual, dysfunctional pathways. Adrenal fatigue patients can present with any of the following symptoms: constant tiredness, need for extra sleep, inability to cope with stress, reduced libido, low back pain in the area of the kidneys, sighing, yawning, recurrent infections, irritability, moodiness, and cravings for sweet foods. Why Herbs? Dysfunctional pathway. The effects of opioids and opioid analogs on animal and human endocrine systems. Pain Sensitivity Related to Brain Structure.