First drug to improve heart failure mortality in over a decade. Lisbon, 25 May 2013: Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality in over a decade and should be added to standard treatment, according to lead author Professor Svend Aage Mortensen (Copenhagen, Denmark). Heart Failure 2013 is being held from 25-28 May in Lisbon, Portugal. It is the main annual meeting of the Heart Failure Association of the European Society of Cardiology (1). Coenzyme Q10 (CoQ10) occurs naturally in the body and is essential to survival. CoQ10 works as an electron carrier in the mitochondria, the powerhouse of the cells, to produce energy and is also a powerful antioxidant. CoQ10 levels are decreased in the heart muscle of patients with heart failure, with the deficiency becoming more pronounced as heart failure severity worsens.
Growing Organs in Lab. Lab-grown human heart tissue beats on its own. Progress in regenerative medicine has been coming fast and furious in recent months: scientists are now using far-out tissue engineering techniques to restore liver function in mice, regrow human muscle, and even implant bioengineered blood vessels into ailing patients. Now, a team at the University of Pittsburgh has managed to grow human heart tissue that can beat autonomously in a petri dish — an exciting step towards devising transplantable replacement organs.
The group, who reported their progress in the journal Nature Communications, used induced pluripotent stem cells (iPS cells) to accomplish the feat. These mature human cells are first "reprogrammed" to an embryonic state, before being spurred to develop into a specialized type of cell. A functional organ capable of beating on its own From there, scientists transplanted the cells onto a mouse heart that had been completely stripped — turning the organ into what's known as a "scaffold. " Mummies reveal that clogged arteries plagued the ancient world. Clogged arteries are seen as the quintessential symptom of an unhealthy modern lifestyle. But the condition was common across the ancient world, even among active hunter–gatherers with no access to junk food, a study of mummies has found.
“There’s a belief that if we go back in time, everything’s going to be OK,” says cardiologist Greg Thomas of the University of California, Irvine, a senior member of the study team. “But these mummies still have coronary artery disease.” The paper is published in the current issue of The Lancet1. Blocked arteries In atherosclerosis, arteries become narrowed and hardened by plaques — made up of cholesterol and immune cells called macrophages — that build up in their walls. A lack of exercise and a diet high in saturated fat — both of which increase levels of 'bad' cholesterol in the blood — are thought to increase the risk of plaques building up. Ancient disease “Now we’ve scanned the common man and woman and they’ve got the same disease,” says Thomas. New Injectable Gel Repairs Muscle Damage After a Heart Attack. A new injectable hydrogel capable of repairing heart tissue after a heart attack has been deemed safe by bioengineers at the University of California, San Diego (UCSD) and is ready for clinical testing in humans this year, according to a recent study published in Science Translational Medicine.
In the United States, an estimated 785,000 heart attacks occur each year, according to a UCSD press release. While a growing number of people survive heart attacks, many patients later develop heart failure due to cardiac tissue damage, “for which the five-year survival rate is only 50 percent,” researchers wrote. "Our data show that this hydrogel can increase cardiac muscle and reduce scar tissue in the region damaged by the heart attack, which prevents heart failure,” said lead researcher Karen Christman, a UCSD professor in the Department of Bioengineering.
“These results suggest this may be a novel minimally invasive therapy to prevent heart failure after a heart attack.” How the Gel Works. Stressed VWF Proteins Can Cause Blood Clots. Rice University researchers in the lab of Ching-Hwa Kiang use the bobbing needle from an atomic force microscope to grab and pull individual protein molecules. By stretching the proteins, Kiang’s team can measure the precise physical forces that shape them. Credit: C. Kiang/Rice University Focusing on a protein called von Willebrand factor (VWF), a team of scientists discovered how stresses of blood flow in small blood vessels of the brain and heart could cause changes to the shape of VWF and form blood clots. New research from Rice University, Baylor College of Medicine (BCM) and the Puget Sound Blood Center (PSBC) has revealed how stresses of flow in the small blood vessels of the heart and brain could cause a common protein to change shape and form dangerous blood clots. The scientists were surprised to find that the proteins could remain in the dangerous, clot-initiating shape for up to five hours before returning to their normal, healthy shape.
“When I first heard what Dr. Image: C. Key to heart failure, new therapies on horizon. Public release date: 5-Mar-2013 [ Print | E-mail Share ] [ Close Window ] Contact: Jeremy WalterJeremy.Walter@tuhs.temple.edu 215-707-7882Temple University Health System (Philadelphia, PA) – Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step underlying the condition that could aid the development of new drugs to treat and possibly prevent it. "Drugs we currently use for heart failure are not very effective," explained lead investigator Walter J.
That is what Koch and colleagues at Thomas Jefferson University and the University of California, Davis, achieved in their latest study, which appears in the March 5 issue of the online journal PLOS ONE. The GRK5 enzyme is a unique member of the GRK family, owing to its presence in the nucleus. The work is an important advance for Temple's Center for Translational Medicine. Vaccine to stop heart attacks could be here in 5 years. Atherosclerosis. Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of the accumulation of calcium and fatty materials such as cholesterol and triglyceride. It reduces the elasticity of the artery walls and therefore allows less blood to travel through. This also increases blood pressure. It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophages and white blood cells and promoted by low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high-density lipoproteins (HDL) (see apoA-1 Milano).
It is commonly referred to as a hardening or furring of the arteries. These complications of advanced atherosclerosis are chronic, slowly progressive and cumulative. Signs and symptoms Search Results. C a r d i o V a x. The Medical Need The death rate from cardiovascular disease has declined by one third in the period of 1994–2004. This decline is the result of new pharmaceuticals, surgical practices, and medical devices being introduced. In spite of these medical advances, cardiovascular disease still remains the number 1 killer, not only of Americans, but of people worldwide. Coronary heart disease is the most prevalent form of atherosclerotic cardiovascular disease.
The Product CVX-210-H is a break-through treatment to ameliorate atherosclerosis through effecting changes in the bodies’ immune responses to the conditions which give rise to atherosclerosis, chiefly high blood levels of LDL cholesterol and its breakdown products. The current view on the role of autoimmunity in atherosclerosis suggests that immune responses against oxidized LDL and other plaque-associated antigens are on the whole protective. Animal Experiments Epidemiological Observations Animal Experiments Proposed Mechanism of Action. A modified virus as a pacemaker. That's why it's really important to pick your viral vectors carefully.
Some vectors are prone to inserting into areas of active chromatin, which is where they can integrate in a way to turn off tumor suppressors or activate oncogenes. But there are viral vectors out there that are more prone to integration into non-active chromatin. And different vectors infect different cell types, so restricting the cell type is often just as important. Lentiviruses are an option. True, I was going to bring that up, but without the use of site specific inducers of DNA Damage to insert genes, there is always a chance.
True. Aspirin. Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damaged walls of blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk of developing blood clots. It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue. Aspirin may be effective at preventing certain types of cancer, particularly colorectal cancer. The main undesirable side effects of aspirin taken by mouth are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses.
Medical use Pain Aspirin 325 mg for pain Headache Fever Dosage Carbon Monoxide and Nitric Oxide (experiment) Carbon monoxide and nitric oxide could widen blood vessels in tiny amounts By Daily Mail Reporter Published: 12:55 GMT, 1 August 2012 | Updated: 12:55 GMT, 1 August 2012 British scientists are working on a pioneering experiment to cure heart disease - by using the toxic chemicals found in car exhaust fumes. Professor Ian Megson, 44, and his team are working on the use of toxic chemicals carbon monoxide and nitric oxide to widen blood vessels and prevent blood clots. Prof Megson said releasing the normally poisonous toxins into the heart in miniscule amounts blocks the body’s ability to clot and relaxes arteries, making them wider and allowing more blood to pass through. British scientists are measuring the impact of tiny quantities of exhaust emissions on pig hearts The treatment is hoped to benefit patients suffering from heart attacks and strokes and was developed by fine-tuning machines used to measure car exhaust emissions in garages.
Statin. Statins (or HMG-CoA reductase inhibitors) are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver, which produces about 70 percent of total cholesterol in the body. Increased cholesterol levels have been associated with cardiovascular disease (CVD). Statins have been found to prevent cardiovascular disease in those who are at high risk. The evidence is strong that statins are effective for treating CVD in the early stages of a disease (secondary prevention). However, the evidence is weaker that statins are effective for those with elevated cholesterol levels but without CVD (primary prevention). Side effects of statins include muscle pain, increased risk of diabetes and abnormalities in liver enzyme tests. Additionally they have rare but severe adverse effects, particularly muscle damage. Moreover, some doctors believe that statins are over-prescribed.
JUPITER trial. The JUPITER trial (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial) is a study aimed at evaluating whether statins reduce heart attacks and strokes in people with normal cholesterol levels. Study rationale JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.
The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP). JUPITER was the first clinical trial to indicate that statin therapy may provide benefit to patients with low-to-normal LDL levels and no known cardiovascular disease. The trial, which began in 2003, was directed by Paul Ridker of Brigham and Women’s Hospital. Study details The trial analyzed 17,802 patients without evidence of heart disease but with high CRP levels. Adverse events Protein That Reverses Heart Disease In Older Mice. Scientists at Harvard University think they have found a way to possibly reverse the aging process in human organs. Dr. Richard Lee, director of regenerative medicine at Brigham and Women’s Hospital, and Amy Wagers, of the Department of Regenerative Biology at Harvard, made the discovery when they were working with younger and older mice.
They took an older mouse with the most common form of human heart failure and merged the mouse’s blood stream with that of a healthy young mouse using a Siamese twin technique known as parabiosis. They found that the older mouse’s diseased heart was able to reverse to a younger healthier condition. They later identified a protein in the blood of young mice called GDF-11, which diminishes with age. Guest: Dr. Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice | The Buck Institute for Research on Aging.
Rapamycin is already FDA approved for other indications June 10, 2013 / Novato, CA Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months. The research, led by a team of scientists at the Buck Institute for Research on Aging, shows how rapamycin impacts mammalian tissues, providing functional insights and possible benefits for a drug that has been shown to extend the lifespan of mice as much as 14 percent. There are implications for human health in the research appearing online in Aging Cell: heart disease is the leading cause of death in the U.S., claiming nearly 600,000 lives per year. Rapamycin is an immunosuppressant drug which can be used to help prevent organ rejection after transplantation. It is also included in treatment regimens for some cancers.
Drug Candidate Leads to Improved Endurance. Flu Shot Prevents Heart Attacks.