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Magic Mushrooms Create a Hyperconnected Brain

Magic Mushrooms Create a Hyperconnected Brain
Magic mushrooms may give users trippy experiences by creating a hyperconnected brain. The active ingredient in the psychedelic drug, psilocybin, seems to completely disrupt the normal communication networks in the brain, by connecting "brain regions that don't normally talk together," said study co-author Paul Expert, a physicist at King's College London. The research, which was published today (Oct. 28) in the Journal of the Royal Society Interface, is part of a larger effort to understand how psychedelic drugs work, in the hopes that they could one day be used by psychiatrists — in carefully controlled settings — to treat conditions such as depression, Expert said. [Trippy Tales: The History of 8 Hallucinogens] Magic mushrooms Psilocybin, the active ingredient in magic mushrooms, is best known for triggering vivid hallucinations. But the drug also seems to have more long-lasting effects. Making connections Drug's effect Related:  psychedelicDrugs & Consciousness

Magic mushrooms defeat tobacco addiction in ground-breaking pilot study The hallucinogenic substance found in magic mushrooms could help smokers kick the habit, according to a pilot study published this week in the Journal of Psychopharmacology. “This is the first study to provide preliminary data on the safety and feasibility of psilocybin as an adjunct to smoking cessation treatment,” Matthew W. Johnson of Johns Hopkins University School of Medicine and his colleagues wrote in their study. “An estimated 5 million worldwide deaths per year are caused by tobacco use, and those numbers are projected to rise to over 8 million deaths annually by 2030. Due to the small size of the study, the researchers cannot make any definite medical recommendations. But the findings — if they are supported by additional research — suggest psilocybin could be one of the most powerful anti-addiction treatments around. Psilocybin-containing mushrooms were outlawed in the United States in 1968 after the drug became associated with the hippie counterculture.

The Ketamine Key Depression, a persistent sad mood and lack of ability to experience pleasure, is a symptom of many psychiatric disorders. It’s debilitating, expensive, and often difficult to treat. Most treatments such as psychotherapy and medications take weeks to kick in, which means lengthy hospitalizations or time off work. The ability to feel pleasure is, in some ways, what makes life worth living. Traditionally, the neurotransmitter thought to be responsible for experiencing pleasure is dopamine. Pharmacologic agents that work on the dopamine system in other ways, such as methylphenidate, sometimes help increase motivation and energy in someone with depression, but it can also cause anxiety, insomnia, and jitteriness. As with everything in the brain, the story isn’t so simple as a single neurotransmitter system like dopamine. The down side to ketamine (besides lack of FDA approval for depression, the hallucinations, and lack of general availability) is that the effects don’t last.

Biological basis for magic mushroom 'mind expansion' discovered -- ScienceDaily New research shows that our brain displays a similar pattern of activity during dreams as it does during a mind-expanding drug trip. Psychedelic drugs such as LSD and magic mushrooms can profoundly alter the way we experience the world but little is known about what physically happens in the brain. New research, published in Human Brain Mapping, has examined the brain effects of the psychedelic chemical in magic mushrooms, called psilocybin, using data from brain scans of volunteers who had been injected with the drug. The study found that under psilocybin, activity in the more primitive brain network linked to emotional thinking became more pronounced, with several different areas in this network -- such as the hippocampus and anterior cingulate cortex -- active at the same time. Psychedelic drugs are unique among other psychoactive chemicals in that users often describe 'expanded consciousness,' including enhanced associations, vivid imagination and dream-like states. Dr.

What We Really Know About Psychedelic Mushrooms For centuries, "magic" mushrooms have been both celebrated and reviled for their mind-expanding properties. Research and popular use of psychedelic drugs like mushrooms and LSD surged in the 1960s, when the substances first entered the American cultural consciousness on a large scale, and came to define '60s counterculture. At this time, thousands of studies were conducted to determine the properties and potential therapeutic applications of the drugs. But in 1970, the Controlled Substances Act brought an end to this era of science-based open-mindedness, and greatly limited drug research for the next four decades. Today, research on psychedelic drugs is experiencing a renaissance of sorts. 'Shrooms are known to trigger hallucinations, feelings of euphoria, perceptual distortions, inability to distinguish fantasy from reality, and sometimes a mystical feelings of oneness with nature. Here's what else we know about mushrooms, what they do the human brain, and how.

Researchers Study the Effects of Psilocybin in Magic Mushrooms on Brain Activity - SciTech Daily A recent study shows how psilocybin, the active ingredient in magic mushrooms, effects brain activity. 30 healthy volunteers underwent MRIs while having psilocybin in their blood and researchers found that psilocybin actually caused activity to decrease in the medial prefrontal cortex, the posterior cingulate cortex, reduced blood flow in the hypothalamus, while participants recalled their recollections as being more vivid after taking psilocybin compared with a placebo. Brain scans of people under the influence of the psilocybin, the active ingredient in magic mushrooms, have given scientists the most detailed picture to date of how psychedelic drugs work. The findings of two studies being published in scientific journals this week identify areas of the brain where activity is suppressed by psilocybin and suggest that it helps people to experience memories more vividly. Psilocybin decreased brain activity in the medial prefrontal cortex and posterior cingulate cortex.

Scientists Studied What Psychedelics Do to the Brain, and It's Not What You've Been Told It turns out that psychedelics aren't just good for turning into an elf and jousting a car. Psychiatrists, psychologists and specialists in addiction and recovery from traumatic experiences have been investigating the use of hallucinogens in treatment programs, and the results indicate that psychedelics actually have practical therapeutic uses. And one drug has proven particularly useful. Repeated studies have found the psychedelic compound found in magic mushrooms, psilocybin, can help people move past major life issues — like beating alcoholism and becoming more empathetic. The research: One study concluded that controlled exposure to psilocybin could have long-lasting medical and spiritual benefits. Fourteen months later, 94% said their trip on magic mushrooms was one of the five most important moments of their lives. What's more, the researchers say that those changes in personality are highly atypical, because personalities tend to be pretty set in stone after the age of 25-30.

HRI News | HRI News HRI News Recovery: an alcoholic’s story and the reemergence of psychedelic medicine | TEDxABQ In this TEDxABQ talk, research scientist Robert Rhatigan discusses his recovery from alcoholism using the psychedelic ayahuasca. In addition to his personal story, Rhatigan gives a brief history of psychedelic research including the work of Heffter researcher Michael Bogenschutz, who studied the treatment of alcoholics using psilocybin. Recovery: an alcoholic’s story and the reemergence of psychedelic medicine | TEDxABQ German documentary about psilocybin features Heffter board member For those of you who can speak German, here is a short clip from a film about Psilocybin as medicine featuring Heffter Board Member Dr. Sie wirken ähnlich wie die Droge LSD auf das Gehirn: Magic mushrooms verändern die Wahrnehmung, machen euphorisch und können Halluzinationen erzeugen. Dorge oder Medizin:”Magic Mushrooms” im Fokus der Wissenschaft Psilocybin, where science meets spirituality | CBS News Dr. Upcoming conferences

Ibogaine For Sale How Magic Mushrooms Change Your Brain Psilocybin is a chemical found in magic mushrooms that causes the user to experience a sensory overload of saturated colors and patterns. Recent research has found that this effect happens because the brain becomes “hyperconnected” and allows for increased communication between different regions. It is hoped that this ability can be manipulated in order to manufacture drugs to treat neurological conditions. The paper was published in an open access format in the Journal of the Royal Society Interface with Giovanni Petri of Italy’s ISI Foundation serving as lead author. The chemical works by binding the same receptors in the brain as the neurotransmitter serotonin. This allows the drug to alter mood. Though previous research surmised that psilocybin decreased brain activity, the current study used functional magnetic resonance imaging (fMRI) to see what was really going on. Simplified illustration of the connections tracked while receiving the placebo (a) and the psilocybin (b).

Psychedelic Researcher: How Drugs Like LSD Can Change Your Life We are currently experiencing a “renaissance” in psychedelic research, as Michael Pollan writes in a recent issue of The New Yorker. Hallucinogenic drugs like psilocybin can be used to treat a range of mental health disorders, from anxiety and addiction to depression, and researchers at the nation’s leading medical schools are intent on discovering their full therapeutic potential. Psilocybin is among a group of drugs labeled "classic psychedelics," which also includes LSD, mescaline and DMT, and has been designated a Schedule I drug since Richard Nixon signed the Controlled Substances Act back in 1971. This classification—which defines a drug as having a high potential for abuse, no accepted medical use, and a lack of accepted safety for use under medical supervision—has made psychedelics very difficult to study in a laboratory setting. Editor’s note: This interview has been condensed and lightly edited for clarity. As for why psychedelics, it’s kind of an interesting story. AK: Go on.

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