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New study uncovers the distinct acute subjective effects of MDMA and LSD MDMA induces only minimal and comparatively weak alterations of consciousness compared with LSD, according to the first controlled study to conduct a head-to-head comparison of the drugs. The findings have been published in the journal Neuropsychopharmacology. “MDMA and LSD are both newly used in psychiatric research to treat PTSD and anxiety disorder respectively. However, differences in the acute effects of these two acutely psychoactive compounds have never been compared directly,” said study author Matthias Liechti, a professor of clinical pharmacology at the University Hospital Basel in Switzerland.

A Woman Accidentally Took 550 Times The Normal LSD Dose, Case Report Details A teenager who accidentally ingested 10 times the normal recreational dose of LSD. A 26-year-old who overdosed on the same drug, not knowing she was pregnant. A woman who took 550 LSD doses all at once, mistaking it for another drug entirely. These exceptional and alarming stories of massive LSD (lysergic acid diethylamide) overdoses that happened to real people are all detailed in a new study, seeking to understand the medical effects of extremely high dosages of psychedelics in recreational settings.

5-MeO-DMT: The new psychedelic with promising mental health benefits A survey study found that around 80 percent of people using the psychedelic 5-MeO-DMT in a ceremonial setting said that their depression or anxiety improved following its use.The "mystical" experience of drug trip might allow people to gain unique insight into themselves or their relationships and make positive life changes.While the substance is found in the poison of the Sonoran Desert Toad, researchers say there is no reason to disturb the toad because the synthetic version of 5-MeO-DMT is identical in its effect. A new, powerful — yet still relatively rare — hallucinogen called 5-MeO-DMT has made its way into United States psychedelic circles, and research is backing its use as an effective treatment for certain mental health conditions. Said to be up to six-times more intense than its sensationalized cousin DMT, researchers have found strong evidence to suggest that 5-MeO-DMT could be used to treat anxiety, depression, and addiction more efficiently than psilocybin.

From mushrooms to ecstasy, a renaissance in psychedelics research Michael Ehlers, a former executive at Biogen and Pfizer, has assumed an advisory role with Field Trip, a psychedelics research organization. Ehlers has followed the science of psychedelics for more than a decade and is excited by the potential for therapeutic applications.MDMA and psilocybin have been granted breakthrough therapy status by the FDA, signaling a shift in the future of mental health treatment. Beyond the bright colors and hallucinogenic imagery of psychedelic art—the visuals of Ram Dass's 1971 book Be Here Now has never left public consciousness — there has long been a crusade to clinically research substances such as LSD, psilocybin, MDMA, DMT, and ibogaine.

68- Earp on the Ethics of Love Drugs In this episode I talk (again) to Brian Earp. Brian is Associate Director of the Yale-Hastings Program in Ethics and Health Policy at Yale University and The Hastings Center, and a Research Fellow in the Uehiro Centre for Practical Ethics at the University of Oxford. Brian has diverse research interests in ethics, psychology, and the philosophy of science. His research has been covered in Nature, Popular Science, The Chronicle of Higher Education, The Atlantic, New Scientist, and other major outlets. We talk about his latest book, co-authored with Julian Savulescu, on love drugs.

How caffeine works: Less blood flow, brain higher entropy Beverages infused with caffeine are by far the most common way the chemical is administered. As a mild stimulant, caffeine is prized for its effects on cognition, attention and alertness. Drinking coffee, tea or soda is an essential and acceptable part of the day for many adults while other psychostimulants—like amphetamines and cocaine—remain highly controlled. A single dose of 5-MeO-DMT produces rapid and persistent improvements in life satisfaction and psychopathological symptoms A single inhalation of the psychedelic drug 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is associated with sustained improvements in satisfaction with life, mindfulness, and a reduction of psychopathological symptoms, according to preliminary research published in Psychopharmacology. “5-MeO-DMT is a lesser known psychedelic compared to, for example, ayahuasca and psilocybin — and thus very limited research exists,” explained study author Malin Uthaug (@malin.uthaug), a PhD candidate at Maastricht University in the Netherlands. 5-MeO-DMT occurs naturally in the venom of some toads and in a variety of plants species. It can also be produced synthetically. “Essentially, I saw this as a niche area, and brought it upon myself to investigate its effect and therapeutic potential further as part of my doctorate work at Maastricht University. This specific article summarizes the first study I did on the topic, but there are more to come,” Uthaug said.

Psychedelics alleviate anxiety and depression in an unexpected way A new systematic review states that serotonergic hallucinogens help users recognize emotions in facial expressions.Sufferers of anxiety and depression often only read negative emotions in other people's faces, adding to their malaise. While more research is needed, psychedelics could prove to be a powerful agent in battling mental health disorders. If you want to know what someone is thinking, don't listen to their words.

Study provides evidence that DMT is produced naturally from neurons in the mammalian brain New research published in Scientific Reports indicates that the rat brain is capable of synthesizing and releasing a powerful psychedelic drug called dimethyltryptamine (DMT). Scientists suspect that the same could be true in humans. “I was initially interested in pineal DMT because I thought DMT may contribute to melatonin production in the pineal gland, which was my main research topic in the early 2000s,” said study author Jimo Borjigin, an associate professor in the departments of molecular and integrative physiology, and neurology at the University of Michigan. The pineal gland is a small structure inside the brain that influences the sleep cycle by secreting the hormone melatonin.

First controlled study of LSD microdosing finds few benefits New research confirms that the alterations in consciousness associated with very low doses of lysergic acid diethylamide (LSD) are not just the result of a placebo effect. But the findings suggest that these “microdoses” might not have many benefits. Preliminary research had indicated that microdosing could improve several aspects of psychological functioning. ­­REACH committee convenes over cancer classification and labelling of titanium dioxide – ChemSec This caused unprecedented levels of lobbying from an industry group calling themselves TDMA – The Titanium Dioxide Manufacturers Association – as reported by, for example, the Corporate Observatory and the Guardian. In 2017, discussions in the Risk Assessment Committee eventually resulted in a proposal to classify the substance as a potential carcinogen, class 2, which is not enough for SVHC identification. It does, however, require labelling of products containing the substance. This was not the end of the discussion, but just the beginning. One of the main arguments concerned the number of products that would be affected by labelling.

Psychedelics alleviate anxiety and depression in an unexpected way A new systematic review states that serotonergic hallucinogens help users recognize emotions in facial expressions.Sufferers of anxiety and depression often only read negative emotions in other people's faces, adding to their malaise. While more research is needed, psychedelics could prove to be a powerful agent in battling mental health disorders. If you want to know what someone is thinking, don't listen to their words. Instead, watch their face.

Nano Titanium Dioxide Technical Information Sheet Nanomaterial Health Hazard Review: Health effects of titanium dioxide nanoparticles Industrial nanomaterials (also called nanoparticles) are defined as substances that are intentionally produced, manufactured or engineered to have specific properties and one or more dimensions typically between 1 and 100 nanometres. Most industrial nanomaterials come in varying sizes, shapes, and in some cases surface coatings. Titanium dioxide (TiO2) nanoparticles, like the regular/bulk form of TiO2, exist in three crystalline structures or polymorphs: rutile, anatase and brookite. They can vary in size and shape, can form agglomerates or aggregates and be coated with other materials. Brookite TiO2 is less common than rutile or anatase TiO2.

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