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The treasure trove of unique genomes hiding in plain sight

The treasure trove of unique genomes hiding in plain sight
Jenn Liv There’s a boxed warning that comes along with Plavix, the anti-blood-clotting drug that hit the market in 1997. If you’re a “poor metabolizer,” it warns, the drug may not be effective for you and might even lead to negative effects. How do you find out if you’re a poor metabolizer? You take a genetic test. However, this FDA-mandated warning about genetic difference was added only in 2010 — after the drug had been on the market for more than a decade. How did a drug like this get through the American drug testing process, while being so ineffective for two large groups of people in the US? Why do Indigenous people have genetic differences? What we’re finding is, some of these diseases may represent adaptations to our ancestors’ local conditions. There are some major challenges to studying Indigenous genomes. In addition, diverse genes can help us understand the complicated way in which diseases work.

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