Overview : Ketamine is a dissociative anesthetic for human and veterinary use. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar, or on the street as Special K. Pharmacologically, ketamine is classified as an NMDA receptor antagonist, and like other drugs of this class such as tiletamine, memantine, and phencyclidine ( PCP ), induces a state referred to as "dissociative anesthesia."
INTENSITY: 10 - Infinity
Stylised depiction of an activated NMDAR. Glutamate is in the glutamate binding site and glycine is in the glycine binding site. Allosteric sites that would cause inhibition of the receptor are not occupied.
The psychedelic drug / entheogen LSD was first synthesized by the Swiss chemist Albert Hofmann in the Sandoz (now Novartis ) laboratories in Basel, Switzerland on November 16, 1938. [ 1 ] It was not until five years later on April 16, 1943, that the psychedelic properties were found. [ 2 ] [ edit ] Discovery Albert Hofmann, born in Baden, Switzerland , joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department. [ 3 ] He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals .
Declassified MKUltra documents Project MKUltra was the code name of a U.S. government covert research operation experimenting in the behavioral engineering of humans (mind control) through the CIA's Scientific Intelligence Division . The program began in the early 1950s, was officially sanctioned in 1953, was reduced in scope in 1964, further curtailed in 1967 and "officially halted" in 1973. [ 1 ] The program engaged in many illegal activities; [ 2 ] [ 3 ] [ 4 ] [ 5 ] in particular it used unwitting U.S. and Canadian citizens as its test subjects, which led to controversy regarding its legitimacy. [ 6 ] [ 7 ] [ 8 ] [ 9 ] MKUltra involved the use of many methodologies to manipulate people's individual mental states and alter brain functions, including the surreptitious administration of drugs (especially LSD ) and other chemicals, hypnosis , sensory deprivation , isolation, verbal and sexual abuse , as well as various forms of torture . [ 10 ]
* Department of History and Classics/Division of Studies for Medical Education, 2–2 Tory Building , University of Alberta, Edmonton, Alberta, T6G 2H4 , Canada.
Uh… Oh… 404 Error It appears that this is not the page you are looking for. It may have moved or may no longer be available. You tried /series/explorer/4094/Overview/ Instead, try one or all of these options: Check the URL to be sure it's spelled correctly.
INTENSITY: 3 to 8 for most experiences.
I am a male (vintage hippy) who has had a fair share of psychadelic experiences in my time.
Overview : Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine), is an entheogen .
INTENSITY: 3 to 7 for most experiences.
In this article, I examine some of the new modes of thinking catalysed by a traditionally esteemed shamanic agent, namely the psilocybin mushroom. I will argue that psilocybin can potentiate an eco-psychological experience in which an intelligent aspect to Nature can be directly ascertained.
O n the night of June 29-30, 1955, in a Mexican Indian village so remote from the world that most of the people still speak no Spanish, my friend Allan Richardson and I shared with a family of Indian friends a celebration of "holy communion" where "divine" mushrooms where first adored and then consumed.