Joe Rogan and Duncan Trussell on the Importance of Psychedelics in 2012. Ketamine. Ketamine. Ketamine. NMDA receptor. Stylised depiction of an activated NMDAR.
Glutamate is in the glutamate-binding site and glycine is in the glycine-binding site. Allosteric sites that would cause inhibition of the receptor are not occupied. LSD (Acid) LSD History Comic. History of LSD. The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938 by the Swiss chemist Albert Hofmann in the Sandoz (now Novartis) laboratories in Basel, Switzerland. It was not until five years later on April 19, 1943, that the psychedelic properties were found. Discovery Albert Hofmann, born in Cyprus, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. ... affected by a remarkable restlessness, combined with a slight dizziness.
Project MKULTRA. Declassified MKUltra documents Project MKUltra — sometimes referred to as the CIA's mind control program — was the code name given to an illegal and clandestine program of experiments on human subjects, designed and undertaken by the U.S.
Central Intelligence Agency (CIA). Experiments on humans were intended to identify and develop drugs and procedures to be used in interrogations and torture, in order to weaken the individual to force confessions through mind control. Organized through the Scientific Intelligence Division of the Central Intelligence Agency (CIA), the project coordinated with the Special Operations Division of the U.S. Concerned with "the research and development of chemical, biological, and radiological materials capable of employment in clandestine operations to control human behavior. " Project MKUltra was first brought to public attention in 1975 by the Church Committee of the U.S. Background Dr. Precursor experiments Welcome to the DMT-Nexus. LSD Treatment for Alcoholism. Erika Dyck* * Department of History and Classics/Division of Studies for Medical Education, 2–2 Tory Building, University of Alberta, Edmonton, Alberta, T6G 2H4, Canada.
E-mail: Erika.firstname.lastname@example.org In the 1950s, researchers in the Canadian province of Saskatchewan began treating alcoholics with d-lysergic acid diethylamide (LSD) and achieved significant rates of recovery. Psychiatrists, including Humphry Osmond who coined the term ‘psychedelic’ while working in Saskatchewan, believed that the successful treatment of alcoholism with biochemical means would scientifically prove that the condition was a disease and not the result of a weak or immoral character. Peyote (Mescaline)
Peyote (Mescaline) Peyote is Schedule I in the United States.
This means it is illegal to manufacture, buy, possess, or distribute without a DEA license, unless it is being used as part of “bonafide religious ceremonies” as per 42 USC §1996a. Mescaline. Mescaline. INTENSITY: 3 to 8 for most experiences.
MATERIAL: Mescaline is a naturally occurring psychedelic found in several cactus species, most notably, Peyote(Lophophora williamsii) and San Pedro (Trichocereus pachanoi). Several other members of the trichocereus family also contain mescaline. Mescaline belongs to a family of compounds known as phenethylamines, making it quite distinct from the other major psychedelics which belong to the indole family. LSD, psilocybin, harmaline, and DMT are all indoles. The Plant with the Answer. I am a male (vintage hippy) who has had a fair share of psychadelic experiences in my time.
None, however could equal up to the life-changing trip I experienced after ingesting 'the divine catus'. It was saturday in El Paso,Texas. I was out of the house by 6 o'clock looking for my well known friend, lysergic acid diethylamide. Now up until this point I had never had a problem finding acid. Psilocybin (Magic Mushrooms) Psilocybin. Psilocybin is Schedule I in the United States.
This means it is illegal to manufacture, buy, possess, or distribute without a DEA license. Not available by prescription. Fresh and dried psilocybin mushrooms are considered containers of Psilocybin, making them illegal to possess as well. Addictive Potential: None. Psilocybin Mushrooms The Extraterrestrial Inflitration of Earth?
Shroomery. Psilocybin and the Concept of Natural Intelligence. In this article, I examine some of the new modes of thinking catalysed by a traditionally esteemed shamanic agent, namely the psilocybin mushroom.
I will argue that psilocybin can potentiate an eco-psychological experience in which an intelligent aspect to Nature can be directly ascertained. I will further argue that such an experience, such an insight into the intelligence inherent within Nature, has a significant curative role to play in our currently beleaguered relationship with the biosphere. An Ivy Trail Leads the Way Some months ago a close friend and I found ourselves camping in a wild place far from the hustle and bustle of the city. Seeking the Magic Mushroom. MDMA (Ecstasy) MDMA Vault : In the Name of Science: Prior Exposure to MDMA May Block High-Dose Neurotoxicity.
"Practically any stimulus capable of causing injury to a tissue or organ can, when applied close to (but below) the threshold of damage, activate endogenous protective mechanisms--thus potentially lessening the impact of subsequent, more severe stimuli.
" -- Dirnagl et al. 20031 One of the more interesting neurotoxicity research findings over the last 25 years is that exposure to a low dose of a neurotoxin can provide protection against more severe damage from a later dose of the same substance. For methamphetamine, this was first documented in 1985,2 and in 2006, researchers found that "chronic, intermittent exposure" to MDMA in rats blocked severe damage to the serotonin system from a later high "binge" dose (Piper et al. 2006).3 A second research group recently published confirmation that pre-treatment with MDMA provides protection against a later neurotoxic dose (Bhide et al. 2009).4 Duration of the prophylactic effect is also unknown. Piper et al.' Ecstasy.
INTENSITY: 2 to 4 MATERIAL: Ecstasy is a synthetic compound developed in 1914 as a potential dietary aid. However, its psychoactive effects were not discovered until the mid-Seventies. It was used widely in therapy from this time until 1985 when it was made illegal. MDMA Main Page. MDMA is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute without a DEA license. Addictive Potential: Low (MDMA is not considered physically addictive, yet it may be psychologically addictive) Emergency Room Visits Yearly: 21,836 hospital visits related to the use of MDMA or ecstasy were reported in 2010 in the United States.
Alexander Shulgin on MDMA. Brain on Ecstasy. An MDMA Neurochemistry Slideshow © Copyright 1998-2014, Emanuel Sferios This slide show will explain the effects of MDMA on your brain. Study: Ecstacy (MDMA) Does NOT Cause Drain Bamage! Breaking Convention: MDMA Debate. MDMA Preloading/Postloading Regimin. 5-HTP before Ecstasy. Health - 5-HTP & ecstasy. Ecstasy & 5-HTP - 5-HTP can ruin Ecstasy - 607. Nice Things to do On E. DMT. Nuerosoup: DMT. DMT ~ Water Spirit. DMT Candy for the Mind. INTENSITY: 9 to 10. Terence McKenna on Entheogens. 2C-B (2CB) Vault. 2C-B. SAFETY FACTORS: 2C-B is highly dosage sensitive. Taking an amount just slightly above the recommended dose can produce an intense experience that most people find forced and unpleasant. With any substance there are a few people who will exhibit unusually high or low sensitivity.
Harmala Alkaloids. Nuerosoup: 2C-B. 2C-B. Brief History. Psychedelic Research of the 1950's and 1960's. Psychedelic Reality. Further Explorations. Psychedelic Safety. Working with Difficult Psychedelic Experiences. Trip Guide. Avoid Bad Trips. Combinations.