In Methuselah's Mould. Figures Citation: O'Neill B (2004) In Methuselah's Mould.
PLoS Biol 2(1): e12. doi:10.1371/journal.pbio.0020012 Published: January 20, 2004 Copyright: © 2004 Bill O'Neill. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abbreviation: IGF-1, insulin-like growth factor-1 The pathologist makes do with red wine until an effective drug is available, the biochemist discards the bread from her sandwiches, and the mathematician indulges in designer chocolate with a clear conscience. “I would take resveratrol if it were feasible,” notes David Sinclair, assistant professor of pathology at Harvard Medical School in Boston, Massachusetts. Aging Theories. The Methuselah Foundation - Welcome to The Methuselah Foundation. Imminst.org - Immortality Institute. Another Illustration as to Why There Will Be Many, Many Genetic.
Another Illustration as to Why There Will Be Many, Many Genetic Contributions to Longevity Loading...
As I mentioned not so long ago, there will most likely prove to be a great many subtle and overlapping genetic variants of human longevity. However, very few of them will be important in the sense that they will lead to ways to significantly increase human life span through new medicine. The effective way to greatly increase human longevity is to learn to repair the biochemical damage of aging, not to tinker with metabolism to slow down the rate at which damage occurs. In any case, here is an excellent illustration as to why there will be thousands of genetic variations that contribute to human longevity: the effects on life expectancy of known single gene variants may be enhanced or diminished by other variations that do not themselves directly contribute to longevity.
Quote: The search for longevity-determining genes in human has largely neglected the operation of genetic interactions. Fight Aging!