PLoS Biol 2(1): e12. doi:10.1371/journal.pbio.0020012. Aging Theories. The Methuselah Foundation - Welcome to The Methuselah Foundation. Imminst.org - Immortality Institute. Another Illustration as to Why There Will Be Many, Many Genetic. Another Illustration as to Why There Will Be Many, Many Genetic Contributions to Longevity Loading...
As I mentioned not so long ago, there will most likely prove to be a great many subtle and overlapping genetic variants of human longevity. However, very few of them will be important in the sense that they will lead to ways to significantly increase human life span through new medicine. The effective way to greatly increase human longevity is to learn to repair the biochemical damage of aging, not to tinker with metabolism to slow down the rate at which damage occurs. In any case, here is an excellent illustration as to why there will be thousands of genetic variations that contribute to human longevity: the effects on life expectancy of known single gene variants may be enhanced or diminished by other variations that do not themselves directly contribute to longevity.