7/21/20: Potentials of plant-based substance to inhabit & probable cure for COVID-19. Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents. Updated April 7, 2020 Background and Introduction Health professionals and the public must be well informed about the COVID-19 virus, the disease it causes, and how it spreads.
This information is readily available and not within the scope of this document. At this time, there are no specific vaccines or uniformly successful treatments for COVID-19. Functional Medicine Approach to COVID-19: Additional Research on Nutraceuticals and Botanicals. Updated May 20, 2020 In this paper, we add to the list of nutraceuticals and botanicals introduced earlier in our first article, The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents.
Periodically, we will update the original list to highlight other agents that may be considered as additional treatments against SARS-CoV. Overview of SARS-CoV 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. A novel coronavirus associated with severe acute respiratory syndrome Ksiazek, Thomas G.; Erdman, Dean; Goldsmith, Cynthia S.; Zaki, Sherif R.; Peret, Teresa; Emery, Shannon; Tong, Suxiang; Urbani, Carlo; Comer, James A.; Lim, Wilina; Rollin, Pierre E.; Dowell, Scott F.; Ling, Ai-Ee; Humphrey, Charles D.; Shieh, Wan-Ju; Guarner, Jeannette; Paddock, Christopher D.; Rota, Paul; Fields, Barry; DeRisi, Joseph; Yang, Jyh-Yuan; Cox, Nancy; Hughes, James M.; LeDuc, James W.; Bellini, William J.; Anderson, Larry J.; Cannon, A.
D. L.; Curtis, M.; Farrar, B.; Morgan, L.; Pezzanite, L.; Sanchez, A. J.; Slaughter, K. Structure of M pro from SARS-CoV-2 and discovery of its inhibitors. No statistical methods were used to predetermine sample size.
The experiments were not randomized and investigators were not blinded to allocation during experiments and outcome assessment. Cloning, protein expression and purification of SARS-CoV-2 Mpro The full-length gene that encodes SARS-CoV-2 Mpro (NC_045512) was optimized and synthesized for E. coli expression (Genewiz). The cloning strategy for producing authentic viral Mpro has previously been reported10.
The expression plasmid was transformed into E. coli BL21 (DE3) cells and then cultured in Luria broth medium containing 100 μg/ml ampicillin at 37 °C. Curcumin: A Review of Its’ Effects on Human Health. 6/6/2020: Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients. 2/22/18: Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway.
Purpose.
This study aimed to evaluate the mechanisms underlying the effects of 1,25-dihydroxyvitamin D (vitamin D3) on diabetes-induced retinal vascular damage and retinal vascular endothelial cell apoptosis. Methods. Diabetic and control rats were randomly assigned to receive vitamin D3 or vehicle for 6 months. 5-6/20: Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus. Quercetin, Inflammation and Immunity.