Scicasts : Using RNA #Nanotechnology to... SciReports: Widespread binding of FUS along... BiotechGuide : New Huntsville biotech company... SciSolutions: #gene #silencing miRNA in muscle... SciSolutions : #RNA Blocking poly-A tailing... Blocking poly-A tailing with a Morpholino. SciSolutions : #gene #silencing Morpholino... Sciencemagazine: RNA-directed targeting system... SciSolutions : #RNA New handbook on RNA quality... New handbook on RNA quality and transcriptomics. MITUpdate: Much at stake in U of Utah's... Sciencemagazine : RNA polymerase "clamp" opens... SciSolutions : #RNA RNA purity...
RNA purity. SciReports: Position-dependent FUS-RNA... SciReports: Ultraviolet Shadowing of R... Foresightnano: Online gamers design RNA m... Foresightnano : Atomically precise DNA-RNA... SciReports : Single-Molecule Electrical... SciSolutions : #Cancer #lifescience i ha... SciSolutions : #Cancer #lifescience i ha... SciSolutions : #Cancer #lifescience i ha... NatureNews: NIH backs disease detectiv... NIH backs disease detectives and RNA sleuths. With the budget of the US National Institutes of Health (NIH) all but stagnant and grant-funding rates at historic lows, the agency’s wiggle room for spending decisions is increasingly tight. But one area in which agency director Francis Collins retains both discretion and dollar power is the NIH director’s Common Fund, a US$545-million pot of money for trans-institute, trans-disciplinary — and, hopefully, transformative — initiatives, each lasting no more than ten years.
Today, Collins announced the latest two of these strategic deployments, both of which will launch in 2013. Building on a successful intramural programme that has generated lots of interest, one initiative is the Undiagnosed Diseases Program (UDP), which will fund extramural centres to work as detectives to diagnose mysterious maladies (see ‘Last chance clinic‘).
The UDP will receive $145 million over five years. New money is always fun, but there can be pain on the other end, when these big, one-time grants run out. NSF: Culling #bats may not stop... SciReports: Involvement of RDR6 in sho... Scicasts : Lariats: How RNA Splicing... Lariats: How RNA Splicing Decisions are Made. Scicasts : Lariats: How RNA Splicing... Lariats: How RNA Splicing Decisions are Made. Science360 : Lariats: How RNA Splicing... Lariats: How RNA Splicing Decisions Are Made. Futureaware : RNA Interference with less... Scicasts : RNA Interference Achieved... RNA Interference Achieved in a Lighter Package. Scicasts : RNA Interference Achieved... Scicasts : RNA Interference Achieved... Arstechnica : Adding iron is like giving... Scicasts : First Complete Atlas of RN...
Scicasts : First Complete Atlas of RN... Scicasts : First Complete Atlas of RN... NatureNews: RT @Ananyo: Fascinating -... NatureNews : Dissolved iron may have be... Dissolved iron may have been key to RNA-based life. Iron now locked in ancient rock formations may have once enabled an 'RNA world'. More than three billion years ago, in the primordial soup that was the cradle of life on Earth, RNA took on many of the roles that its sister molecule DNA fills today — or so some scientists have speculated.
A paper published 31 May in PLoS ONE posits one way that such an ‘RNA world’ could have worked: by making use of iron, a common element in the watery environs of ancient Earth. In an RNA-dominated world, “RNA would have been the genetic material, and would have been the primary enzyme in metabolism,” says Loren Dean Williams, a chemist at the Georgia Institute of Technology in Atlanta and a co-author on the paper. Today, RNA is best known as the messenger of genetic information, but large RNA molecules can fold into more complex structures, called ribozymes, with the ability to cut or glue other RNAs together.
“We’re used to our world of oxygen, and oxygen and iron is just a terrible combination. Tssinews : "Structure of Human Protei... Futureaware: RNA breakthrough transform... Sciencemagazine : Inside Argonaute2, core pr... Futureaware: Atomic force microscope br... SciSolutions : #gene #silencing dre-miRNA... SciSolutions : #Biotechnology Mirna Thera... Scicasts: RNA Modification Influence... RNA Modification Influences Thousands of Genes. Scicasts: RNA Modification Influence... Scicasts: RNA Modification Influence... Scientist Solutions: #RNA mRNA Methylation Enri... Scitable: "Translation: DNA to mRNA... Scientist Solutions: #NIH NIH Awards $850K in G... Science Magazine: High-res crystal structure... Scientist Solutions: #NIH Scripps Gets NIH Fund... Scientist Solutions: #lifescience #jobs miRNA/B...
Scientist Solutions: #RNA microRNA in situ hybr... NatureNews: RT @m_m_campbell: Silence... Nature News&Comment: Most popular - lotsa noise... NatureNews: RNA studies under fire htt... RNA studies under fire. High-throughput RNA sequencing has yielded some unexpected results in the past few years — including some that seem to rewrite conventional wisdom in genetics.
But a few of those findings are now being challenged, as computational biologists warn of the statistical pitfalls that can lurk in data-intensive studies. The latest case centres on imprinted genes. Humans and most other animals inherit two copies of most genes, one from each parent. But in some cases, only one copy is expressed; the other copy is silenced. In such cases, the gene is described as being imprinted. Now, researchers are arguing that a flawed analysis led Dulac and Gregg to vastly overestimate imprinting in their paper. Dulac counters that she and her team “absolutely stand by those data”, adding that they have confirmed some of their findings by other means. But Babak says that the statistical methods Dulac and Gregg used were not rigorous enough to rule out false positives. Twitter. Locked RNA Editing Yields Odd Fly Behaviour. Sciencemagazine: Targeted delivery of siRNA...
KQEDscience: Researchers make alternati... Scientists make alternatives to DNA and RNA. DNA and RNA molecules are the basis for all life on Earth, but they don't necessarily have to be the basis for all life everywhere, scientists have shown. Researchers at the Medical Research Council in Cambridge, England, demonstrated that six synthetic molecules that are similar to — but not exactly like — DNA and RNA have the potential to exhibit "hallmarks of life" such as storing genetic information, passing it along and undergoing evolution. The man-made molecules are called "XNAs. " "DNA and RNA aren't the only answers," said Vitor Pinheiro, the postdoctoral researcher who led the study, which was published this week in the journal Science. Synthetic DNA: An April 21 article in Section A about scientists' studies of synthetic DNA said that viruses used only RNA to store genetic information. In fact, some viruses encode genetic instructions in DNA, like nearly all organisms on Earth Manipulating XNAs to behave like DNA and RNA could help scientists design better drugs, Pinheiro said.
Scitable: "Synthetic Nucleic Acids:... Society of Biology: Synthetic Nucleic Acids: B... Nature.com blogs: Synthetic Nucleic Acids: B... Scientist Solutions: #DNA #PCR Rna quantificati... Rna quantification. Hi Worcesterman, Unfortunately I am not familiar with the MWG lambda scan 200 so I cannot give you a true explanation of what their different measurements mean. Still, this is what I can say with a high degree of certainty: 1. Assuming that you are using the right instrument setting for the cuvette you are using, the pathlength corrected measurements should be the best measurements you have since the instrument has already corrected for any bias caused by your cuvette's plastic/glass. 2.
Most UV specs automatically calculate most necessary readings, such as the 260/280 ratio, but if yours does not I would try to minimize the amount of calculations you perform. Best. Scientist Solutions: #MRC Researchers make alte... Scientist Solutions: #MRC Researchers make alte... National Science Fdn: From the field: Seed Size... Scientist Solutions: #lifescience #jobs IIAR Ko... Twitter.