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Drugs, Receptors

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The Physiology, Signaling, and Pharmacology of Dopamine Receptors. Alcohol shown to act in same way as rapid antidepressants. Yes.

Alcohol shown to act in same way as rapid antidepressants

At least in terms of biochemistry. In a study published in the current issue of the journal Nature Communications, researchers found that alcohol produces the same neural and molecular changes as drugs that have proven to be rapidly effective antidepressants. Specific neurotransmitter receptor supports optimal information processing in the brain. Researchers have been fascinated for a long time by learning and memory formation, and many questions are still open.

Specific neurotransmitter receptor supports optimal information processing in the brain

Bochum-based neuroscientists Prof Dr Denise Manahan-Vaughan and Dr Hardy Hagena have discovered a key building block for this complex process. A particular neurotransmitter receptor, namely the metabotropic glutamate receptor 5, is a switch for activating opposing forms of plasticity in the hippocampus, a brain region vital for memory forming. They reported in the current edition of "The Journal of Neuroscience. " Synapses between neurons process different information. Magic mushroom ingredient psilocybin could be key to treating depression - studies. A single dose of psilocybin, the active ingredient of magic mushrooms, can lift the anxiety and depression experienced by people with advanced cancer for six months or even longer, two new studies show.

Magic mushroom ingredient psilocybin could be key to treating depression - studies

Researchers involved in the two trials in the United States say the results are remarkable. The volunteers had “profoundly meaningful and spiritual experiences” which made most of them rethink life and death, ended their despair and brought about lasting improvement in the quality of their lives. The results of the research are published in the Journal of Psychopharmacology together with no less than ten commentaries from leading scientists in the fields of psychiatry and palliative care, who all back further research. The Drug That Never Lets Go. Photo By @FatTonyBMX Dickie Sanders was not naturally prone to depression.

The Drug That Never Lets Go

The 21-year-old BMX rider was known for being sweet spirited and warm -- a hugger not a hand-shaker. The kind of guy who called on holidays. Who helped his father on the family farm. Harvard Cell Animation.mp4. Top Neuroscientist Explains How Big Pharma’s Adderall Is Essentially Crystal Meth. Top Neuroscientist Explains How Big Pharma’s Adderall Is Essentially Crystal Meth Anyone who’s ever been given one of their friend’s Adderall knows the powerful effects brought on by this tiny unintimidating pink pill.

Top Neuroscientist Explains How Big Pharma’s Adderall Is Essentially Crystal Meth

Increased energy, enhanced ability to focus and concentrate, and a euphoric sense of being are the most common effects of this drug. Coincidentally, increased energy, enhanced ability to focus and concentrate, and a euphoric sense of being — are also the most common effects of crystal meth. So, why are these effects so similar? Neuroscientist: Meth Is Virtually Identical to Adderall—This Is How I Found Out.

The long subway ride from DC’s airport to Silver Spring was unusually pleasant.

Neuroscientist: Meth Is Virtually Identical to Adderall—This Is How I Found Out

It had been about an hour since I had taken a low dose of methamphetamine. It was my 40th birthday—October 30, 2006—and I was headed to a National Institute on Drug Abuse (NIDA)-sponsored meeting. A friend, who had a prescription for the drug, had given me a couple of pills as a gift, knowing that I was an expert on amphetamines but had never actually taken any myself. I sat on the train feeling alert, mentally stimulated, and euphorically serene. The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse. N-methyl-D-aspartate receptors (NMDARs) are a major subtype of glutamate-gated ion channels at the excitatory synapses in the central nervous system (CNS), which mediate the flow of sodium (Na+) and calcium (Ca2+) ions into the cell and potassium ions (K+) out of the cell.

The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse

NMDARs are heterotetrameric plasma membrane channels composed of two obligatory GluN1 and two modulatory GluN2 (A-D) subunits (Cull-Candy et al., 2001; Collingridge et al., 2009), although sometimes the GluN2 subunits are replaced by GluN3(A-B) subunits (Ulbrich and Isacoff, 2008). NMDARs form a diheteromer when the two GluN2 subunits are identical, or a triheteromer when two different GluN2 subunits co-assemble with two identical GluN1 subunits (Ulbrich and Isacoff, 2008; Collingridge et al., 2010). At resting state, NMDARs are blocked by the presence of extracellular magnesium ions (Mg2+) in the channel pore (Vargas-Caballero and Robinson, 2004). Opioid Receptor-Dependent Signaling and Behavior. Overview of psychopharmacology. The Search for Ligands with images. Voltage-gated ion channels. Ligand-gated ion channels. Other ion channels.

G protein-coupled receptors. Guide to PHARMACOLOGY protein targets and ligands. Concise Guide to PHARMACOLOGY Overview. Guide to Receptors and Channels (GRAC), 5th edition - Alexander - 2011 - British Journal of Pharmacology.