Twitter Bootstrap. Need reasons to love Bootstrap?
Look no further. By nerds, for nerds. Built at Twitter by @mdo and @fat, Bootstrap utilizes LESS CSS, is compiled via Node, and is managed through GitHub to help nerds do awesome stuff on the web. Made for everyone. Backbone.js. Backbone.js gives structure to web applications by providing models with key-value binding and custom events, collections with a rich API of enumerable functions, views with declarative event handling, and connects it all to your existing API over a RESTful JSON interface.