Planet Hunters. EteRNAQuadEnergyTable2.png (PNG Image, 683x564 pixels) Solve Puzzles for Science | Foldit. Loops Guide. Mpb21's Loop Guide: When solving challenge puzzles and submitting solutions for the RNA Lab, it is important to pay attention to the loops. Because it is just as important to make sure that the pairs stay together as it is to make sure that the loops stay apart. The general method for solving a loop is to place the pairs in the stacks around it, then start on the loop. "Adjacent" nucleotides circled in black. Common loops Following are some of the more common loops that you will see and the improvements that can be made by adding one or more G’s to the loop. 1-1 Loop Before: 1.7kcal/mol After: -0.4 kcal/mol 2-2 Loop 2.8 kcal/mol 0.5 kcal/mol 1-3 Loop 4.1 kcal/mol 1.9 kcal/mol 4-1 Loop 4.7 kcal/mol 2.5 kcal/mol 4 Loop 5.3 kcal/mol 5 Loop 5.1 kcal/mol 4.5 kcal/mol Putting guanine's in the adjacent positions can be crucial for stabilizing short stacks.
Does not fold: Folds: This is not an exhaustive list of loops, and more will be added to it soon. mpb21.