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The natural psychedelics have been in use for thousands of years, and I anticipate that both synthetic and natural psychedelics will still be used thousands of years from now. Contrary to being considered dangerous, throughout most of history psychedelics have been considered gifts of the Gods, and have been associated with the healing of the body, mind and soul.
Note to the Reader During the peak of one of my first LSD trips I came to the realization that all the knowledge of the universe was at my fingertips. So, I seized the moment and asked myself some the universal questions I had always wondered about.
SAFETY FACTORS: All of the multiple combinations listed here I have tried in my personal experiments.
The mammalian 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [ 1 ] This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT 2A may also have an inhibitory effect [ 2 ] on certain areas such as the visual cortex and the orbitofrontal cortex . This receptor was first given importance as the target of serotonergic psychedelic drugs such as LSD . Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.
INTENSITY: 10 - Infinity
Stylised depiction of an activated NMDAR. Glutamate is in the glutamate binding site and glycine is in the glycine binding site. Allosteric sites that would cause inhibition of the receptor are not occupied.
Overview : Ketamine is a dissociative anesthetic for human and veterinary use. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar, or on the street as Special K. Pharmacologically, ketamine is classified as an NMDA receptor antagonist, and like other drugs of this class such as tiletamine, memantine, and phencyclidine ( PCP ), induces a state referred to as "dissociative anesthesia."
INTENSITY: 3 to 8 for most experiences.
SAFETY FACTORS: 2C-B is highly dosage sensitive.
INTENSITY: 1 to 2. Harmala alkaloids are usually not potent psychedelics when taken alone. Their main use is to potentiate other psychedelics.
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I am a male (vintage hippy) who has had a fair share of psychadelic experiences in my time.
As prehistoric men and women foraged for food they must have eaten the psychedelic plants which grow in nearly all regions of the world. Ingesting these plants would have produced awe inspiring experiences, and it is quite likely that the origin of ideas about gods, heavens and hells, life after death, etc. began with the ingestion of psychedelic plants. Try to imagine yourself as a neolithic human, most of your attention given to day-by-day survival, the more complex areas of your brain just beginning to develop.
There exists a state which I will call "CydelikSpace," that I have visited numerous times through the use of psychedelics. CydelikSpace has correlations to the digital world of "cyberspace" described in William Gibson's novels. However, CydelikSpace is not a fictional dimension.