background preloader

The 5 Greatest Things Ever Accomplished While High

The 5 Greatest Things Ever Accomplished While High's new book is now on sale. What follows is one of the classic articles that appear in the book, along with 18 new articles that you can't read anywhere else. Any dreadlocked white guys finding this article after Googling "Drugs Rule" should know that we've given this list about drugs a rule. To make the cut, an accomplishment has to be considered great by people who could pass a field sobriety test. So no Grateful Dead music. We're sure someone somewhere has enjoyed the Dead perfectly sober, just as there are probably non-Christians who listen to Christian Rock. In fact, because we're masochists, we gave ourselves a strict no music policy, leaving us with ... well, not a whole lot actually. Francis Crick Discovers DNA Thanks to LSD The Accomplishment: For the few Cracked readers not versed in the history of human genetics, Francis Crick is the closest that field gets to a rock star, which is pretty fucking close as it turns out. Above: Science? The Drug: LSD. Drugs? Cocaine.

Related:  1

The 9 Most Badass Last Words Ever Uttered: Part 2 Hello there, dear readers. We hope you're having a wonderful day. We just wanted to take a moment to remind you that you are most likely going to die in total obscurity. Alcohol 1999 BBC News Health: Alcohol benefits debunked Moderate alcohol consumption has no positive effect on health 2005 CDC Study Skeptical on Moderate Drinking's Heart Benefit Moderate alcohol consumption should not be recommended 2005 Alcohol's health benefits doubted Gains are likely outweighed by the harm

5-HT2A Receptor The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).[1] This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect[2] on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first given importance as the target of serotonergic psychedelic drugs such as LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. 5-HT2A may be a necessary receptor for the spread of the human polyoma virus called JC virus.[3] Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of SSRIs and classical antipsychotics. Deceased suicidal and otherwise depressed patients have had more 5-HT2A receptors than normal patients.

Do a Barrel Roll and Top 10 All Time BEST Hidden Google Easter Eggs - TechChunks There are a number of gags, pranks, goofs and hidden messages within the search engine giant, Google, which are popularly called as Easter Eggs. For instance, the Google “do a barrel roll” search caught plenty of attention this week — but it’s only one of many Easter eggs the Internet giant has hidden around the Web. We had earlier compiled a list of awesome Google Search tricks and we had discovered how to Convert Google Translate Into a Beatbox Machine.

Ibogaine : Welcome to The Jungle -=/[ Ibogaine ]/=- The Whole Entire Everything (in its complete totality... partially) Copyright © 2005-2008, Patrick K. 7 Bizarre Easter Eggs Hidden in Great Works of Art We tend to think of classic art as being all dignified and serious, if perhaps a little stuffy. But that's only because we're not looking closely enough. As we've pointed out before, a lot of classical art is like a "Where's Waldo?" picture, but with more bare breasts and less mockery from your peers if they catch you puzzling over it. #7. 5 Amazing New Experimental Drugs I'm the resident Alternative Lifestyle Specialist around here (which is what I keep asking my boss to call me instead of "drug-addled wreck of a human being"), so when new pharmaceutical trends sweep through the United States like Daniel Larusso's leg, it's up to me to cover them. I'm talking about a new class of drugs called "nootropics" - though "new" is a subjective term. They've been around for decades now, but they're only just recently taking off with a drastic rise in casual use. The truly great thing about nootropics is that, by and large, they're utterly harmless; they're meant to boost mental function with little to no side effects--regardless of dosage. Because of this, most of them are available freely on the market as "supplements." So I'll be testing out and reviewing the five most popular ones.

Harmala Alkaloids INTENSITY: 1 to 2. Harmala alkaloids are usually not potent psychedelics when taken alone. Their main use is to potentiate other psychedelics. SAFETY FACTORS: Harmala alkaloids are MAO inhibitors. See list of items not to take with MAO inhibitors in the Safety chapter. The Harmala alkaloids are emetics and can produce intense nausea if used in large amounts. 7 Classic Disney Movies Based On R-Rated Stories Hercules: Murders His Children The Disney Happy Ending: In the Disney version we have our hero Hercules versus Hades, who tries to take out Hercules by sending Meg, a woman whose job it is to find Hercules' weakness. As she is a moderately attractive 18- to 25-year-old woman, she falls in love with him instead as required by Disney law. Since his first plan failed so miserably, Hades gets Hercules to give up his powers in exchange for Meg's safety, which seems like a reasonable trade until you remember that Hades is like Satan with more gold trim, so he predictably goes back on his word.

The secret history of psychedelic psychiatry : Neurophilosophy This post is part of a Nature Blog Focus on hallucinogenic drugs in medicine and mental health, inspired by a recent Nature Reviews Neuroscience paper, The neurobiology of psychedelic drugs: implications for the treatment of mood disorders, by Franz Vollenweider & Michael Kometer. This article will be freely available, with registration, until September 23. See the Table of Contents for more information on this Blog Focus, and read the other blog posts: Update: I summarize all four posts in this article for The Guardian, and there’s more coverage of the Blog Focus at 3 Quarks Daily, The Atlantic (Alexis Madrigal and Andrew Sullivan), Boing Boing and The Great Beyond.

6 Fictional Places You Didn't Know Actually Existed Part of what makes fantasy and sci-fi appealing is that it's not just a bunch of characters -- it's a whole world. One you want to live in. That's true even if it's an objectively bad place -- Gotham City looks like a shithole, but who wouldn't trade their current life with a chance to go there and fight supercriminals with Batman?

Related:  FunnyhumorcrackedNar