Tricyclic antidepressant. Tricyclic antidepressant wiki. Dopamine reuptake inhibitor wiki. A dopamine reuptake inhibitor (DRI) is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the post-synaptic neuron is blocked from re-entering the pre-synaptic neuron.
This, in turn, leads to increased extracellular concentrations of dopamine and therefore an increase in dopaminergic neurotransmission.[1] DRIs are frequently used in the treatment of conditions like ADHD and narcolepsy on account of their psychostimulant effects and in the treatment of obesity due to their appetite suppressant properties. They have also been used as antidepressants in the treatment of mood disorders, but their use for this indication has been limited on account of their abuse potential and legal restriction. Society and culture[edit] History of use[edit] Pharmacotherapeutic uses[edit] Bupropion[edit] List of DRIs[edit] Other DRIs[edit]
MAOI google. MAOI. SNRI wiki. Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs used in the treatment of major depression and other mood disorders. They are sometimes also used to treat anxiety disorders, obsessive-compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), chronic neuropathic pain, and fibromyalgia syndrome (FMS), and for the relief of menopausal symptoms.
SNRIs are potent inhibitors of serotonin (5-Hydroxytryptamine, 5-HT) and norepinephrine (NE, noradrenalin) reuptake. These neurotransmitters are known to play an important role in mood. These can be contrasted with the more widely used selective serotonin reuptake inhibitors (SSRIs), which act upon serotonin alone. The human serotonin transporter (SERT) and norepinephrine transporter (NET) are membrane proteins that are responsible for the reuptake of serotonin and norepinephrine. Overview of SNRIs[edit] Venlafaxine (Effexor) – The first and most commonly used SNRI. Timeline of approved SNRIs. SSRI wiki. Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor[1] (SSRIs) are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders.
SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having only weak affinity for the noradrenaline and dopamine transporter.
Medical uses[edit] The main indication for SSRIs is major depressive disorder (also called "major depression", "clinical depression" and often simply "depression"). Depression[edit] There has been controversy regarding the efficacy of antidepressants in treating depression depending on its severity and duration. Generalized anxiety disorder[edit] Antidepressants (Short) SSRI. SSRI. General Antidepressants.