Language Acquisition News. Learning. Time-lapse images of a zebrafish neuron loaded with a calcium sensor during depolarization. Consciousness. Histamine. Chemical compound Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.[3][4] Since histamine was discovered in 1910, it has been considered a local hormone (autocoid) because it lacks the classic endocrine glands to secrete it; however, in recent years, histamine has been recognized as a central neurotransmitter.[5] Histamine is involved in the inflammatory response and has a central role as a mediator of itching.[6] As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Properties[edit] The tele tautomer (Nτ-H-histamine), on the left is more stable than the pros tautomer (Nπ-H-histamine) on the right.
Synthesis and metabolism[edit] Storage and release[edit] Histamine release occurs when allergens bind to mast-cell-bound IgE antibodies. History[edit] Genetic Scientists Eliminate Schizophrenia Symptoms in Mice | Genetics. A multinational group of geneticists writing in the journal Neuron has reversed schizophrenia-like symptoms in adult mice by restoring normal expression to a gene called Neuregulin-1 (NRG1 for short).
Roles of Neuregulin 1 in neural development. NRG1 is released from neurons to promote the formation and maintenance of radial glial cells. Tangential migration of γ-aminobutyric acid-ergic interneurons requires NRG1 in the cortical region. Myelination and ensheathment of peripheral nerves are controlled by the amounts of NRG1 produced in substrate axons. NRG1 from axons might regulate oligodendrocyte development and myelination of axons in the CNS. Targeting expression of NRG1, which makes a protein important for brain development, may hold promise for treating at least some patients with the brain disorder. “They found that when elevated, mice were hyperactive, couldn’t remember what they had just learned and couldn’t ignore distracting background or white noise.
Logic.