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The eChallenges e-2006 Conference took place from 25 - 27 October in Barcelona, Spain. eChallenges e-2006 attracted over 640 delegates from 53 countries, representing government (23%), industry (15.5%), high-tech SMEs (13.5%) and research/academic organisations (48%) and Exhibitors from 17 countries. Keynote speakers from Belgium, Netherlands, Romania, Spain and Switzerland shared insights into current applied ICT challenges in government, business and research. eChallenges e-2006 incorporated over 300 presentations from 46 countries and five continents. Continuing a trend of increasing international participation in the eChallenges Community, almost 8% of presenters and 8% of delegates at e-2006 are from outside Europe.