METHIMAZOLE - National Library of Medicine CCRIS Database. CAS Home Page.
Medicine. Graves' disease. Graves' disease (or Basedow-Graves disease) is an autoimmune disease.
It most commonly affects the thyroid, frequently causing it to enlarge to twice its size or more (goiter), become overactive, with related hyperthyroid symptoms such as increased heartbeat, muscle weakness, disturbed sleep, and irritability. It can also affect the eyes, causing bulging eyes (exophthalmos). It affects other systems of the body, including the skin, heart, circulation and nervous system. Pathogenesis of Graves' disease. Graves' disease is a syndrome that may consist of hyperthyroidism, goiter, eye disease (orbitopathy), and occasionally a dermopathy referred to as pretibial or localized myxedema.
The terms Graves' disease and hyperthyroidism are not synonymous, because some patients may have orbitopathy but no hyperthyroidism, and there are many other causes of hyperthyroidism in addition to Graves' disease. Hyperthyroidism is the most common feature of Graves' disease, affecting nearly all patients, and is caused by autoantibodies to the thyroid stimulating hormone (TSH, thyrotropin) receptor (TSHR-Ab) that activate the receptor, thereby stimulating thyroid hormone synthesis and secretion as well as thyroid growth (causing a diffuse goiter). The presence of TSHR-Abs in serum and orbitopathy on clinical examination distinguishes the disorder from other causes of hyperthyroidism.
Home. Methimazole CAS (60-56-0) sc-205747. Atenolol. (RS)-Atenolol CAS (29122-68-7) sc-204895. Www.oehha.ca.gov/prop65/prop65_list/files/P65single021712.pdf. Hyperthyroidism. Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland produces and secretes excessive amounts of the free (not protein bound circulating in the blood) thyroid hormones -triiodothyronine (T3) and/or thyroxine (T4).
Graves' disease is the most common cause of hyperthyroidism. The opposite is hypothyroidism ('sluggish thyroid'), which is the reduced production and secretion of T3 and/or T4. Disease management and therapy differ for thyrotoxicosis caused by hyperthyroidism and thyrotoxicosis caused by other conditions.
Hyperthyroidism and Graves' Disease. Pretibial myxedema is a skin condition that may develop in patients with Graves’ disease.
It is characterized by thickening of a layer of tissue that lies directly beneath the surface of skin called the dermis. The word “pretibial” refers to the fact that this thickening usually involves the skin that covers the front of the tibia bone in the lower leg. Other terms used to identify this disorder include localized myxedema and thyroid dermopathy. Pretibial myxedema usually becomes evident when raised lesions begin to appear on the skin that covers the front surfaces of the shins. BTEX Definition Page. Definitions BTEX - "BTEX is the term used for benzene, toluene, ethylbenzene, and xylene-volatile aromatic compounds typically found in petroleum product, such as gasoline and diesel fuel.
" - Environmental Protection Agency, 2010 BTEX (benzene, toluene, ethylbenzene, and xylene) - "Volatile, monocyclic aromatic compounds present in coal tar, petroleum products, and various organic chemical product formulations (Cohen and Mercer, 1993). These are the most soluble of the major gasoline compounds and, therefore, are common indicators of gasoline contamination.
" - Wilson and Moore, 1998 BTEX (benzene, toluene, ethylbenzene, and xylene) - "BTEX is a group of chemicals which is quantified by one analytical method...Toluene, ethylbenzene, and the three isomers of xylene are colourless liquids, immiscible with water but miscible with organic solvents. They have a characteristic strong odour and are highly flammable.
" - European Environment Agency, 2010. IUPAC Gold Book. International Union of Pure and Applied Chemistry. National Library of Medicine - National Institutes of Health. TOXMAP - TRI and Superfund Environmental Maps. IPCS INCHEM. Toxicological Abbreviations. TRI and Superfund Map. Acrylamide (PIM 652) 1.1 Substance 1.2 Group 1.3 Synonyms 1.4 Identification numbers 1.4.1 CAS number.