background preloader

Arpaton

Facebook Twitter

arpaton

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement. Microfluidic technologies for synthetic biology. [Int J Mol Sci. 2011] - PubMed result. Methods in Enzymology : Multiplexed Genome Engineering and Genotyping Methods : : Applications for Synthetic Biology and Metabolic Engineering. Bringing It Together with RNA.

Automatic Compilation from High-Level Biologically-Oriented Programming Language to Genetic Regulatory Networks. Citation: Beal J, Lu T, Weiss R (2011) Automatic Compilation from High-Level Biologically-Oriented Programming Language to Genetic Regulatory Networks. PLoS ONE 6(8): e22490. doi:10.1371/journal.pone.0022490 Editor: Eshel Ben-Jacob, Tel Aviv University, Israel Received: March 15, 2011; Accepted: June 22, 2011; Published: August 5, 2011 Copyright: © 2011 Beal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: NIH R01: “Engineering Synthetic Multicellular Systems” (Grant # 7R01GM74712-5) ( Competing interests: The authors have read the journal's policy and have the following conflicts: Jacob Beal is an employee of BBN Technologies. Introduction Figure 1. (a) This paper extends the Proto spatial computing language with mechanisms for genetic regulatory network design (pink). . And. The Allure of Synthetic Biology. Biologists have been manipulating genomes ever since Paul Berg first described a method to covalently join duplex DNA molecules in 1972. Despite key fundamental insights, a thriving biotechnology industry, and a growing number of medical applications, there have been limits to what has been possible. Now, synthetic biology goes beyond engineering individual genes to the construction of DNA-encoded circuits that can be programmed to control cell behavior.

This emerging field brings together biologists, physicists, chemists, and engineers who seek both to understand life and to build new biological functions. For example, Harvard's George Church wants to redesign the genetic code (p. 1236). Nandagopal and Elowitz (p. 1244) describe how building circuits and studying their behavior in cells can provide insight into biological design principles. In these examples, the assembly of the synthetic systems is within an existing organism. A Grand Challenge in Biology. Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells. 110118_imaginenano. Sequential Establishment of Stripe Patterns in an Expanding Cell Population.

Pearltrees videos

Getting started.