Ying Fang
Sign In. Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics.
Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) More Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics. Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) antibodies (R1MAbs) that mimic the metabolic effects of FGF21. A single injection of R1MAb into obese diabetic mice induced acute and sustained amelioration of hyperglycemia, along with marked improvement in hyperinsulinemia, hyperlipidemia, and hepatosteatosis.
Infectious diseases/ microbiology. Welcome to KeyGen.us ! Cracks, serial numbers, keygens. Unlock Your Software. 申请美国留学签证（F1签证）流程（二）填写签证申请表DS-156/DS-157/DS-158 - 美国签证 - 滴答论坛. 浙江理工大学. Untitled. 影视英语 - 大家论坛. The McGraw-Hill Companies.
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