2. Acute Oxalate Nephropathy After Massive Ascorbic Acid Administration. High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. The return of the revenge of high dose vitamin C for cancer « Science-Based Medicine. Somehow, I’ve a feeling we’re not in Kansas anymore—except that we are, as you will soon see.
Because I’m the resident cancer specialist on this blog, it usually falls on me to discuss the various bits of science, pseudoscience, and quackery that come up around the vast collection of diseases known collectively as “cancer.” I don’t mind, any more than my esteemed colleague Dr. Crislip minds discussing infectious diseases and, of course, vaccines, the most effective tool there is to prevent said infectious diseases. In any case, there are certain things that can happen during a week leading up to my Monday posting slot on SBM that are the equivalent of the Bat Signal.
Call them the Cancer Signal, if you will. In any case, this week’s Cancer Signal consisted of a series of articles and news reports with titles like: These stories, to varying degrees, miss the point. Be that as it may, a typical story describes the recently published research thusly: Vitamin C strikes (out) again « Science-Based Medicine. I didn’t think I’d be revisiting this topic again so soon.
After all, I wrote one of my characteristic magnum opuses (opi?) Less than two months ago, when I asked whether a recent animal study had vindicated Linus Pauling’s belief that high dose vitamin C is a highly effective cancer treatment. After that tsunami of verbiage that can only be exceeded by my fellow blogger Dr. Atwood when he’s on a roll doing a multipart deconstruction of some woo or other, I thought it would be best to give it a rest for a while. I guess less than two months will have to be enough. Ascorbic acid: Chemistry, biology and the treatment of cancer. Intravenous Vitamin C Published Clinical Results by Other Groups. This phase I clinical trial evaluated the safety, tolerability, and pharmacokinetics of high-dose intravenous (i.v.) ascorbic acid as a monotherapy in patients with advanced solid tumors refractory to standard therapy.
Five cohorts of three patients received i.v. ascorbic acid administered at 1 g/min for 4 consecutive days/week for 4 weeks, starting at 30 g/m(2) in the first cohort. For subsequent cohorts, dose was increased by 20 g/m(2) until a maximum tolerated dose was found. Ascorbic acid was eliminated by simple first-order kinetics. Half-life and clearance values were similar for all patients of all cohorts (2.0 ± 0.6 h, 21 ± 5 dL/h m(2), respectively). C max and AUC values increased proportionately with dose between 0 and 70 g/m(2), but appeared to reach maximal values at 70 g/m(2) (49 mM and 220 h mM, respectively). Ascorbic acid administered i.v. at 1 g/min for 4 consecutive days/week for 4 weeks produced up to 49 mM ascorbic acid in patient’s blood and was well tolerated. Phytoagents for Cancer Management: Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms. Vitamin C - What You Don't Know May Kill You AND Why The USDA Is Wrong.
Levine AA Cancer H2O2.pdf. Vitamin C and cancer revisited. Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany. + Author Affiliations.
Intravenous Vitamin C and Cancer. A Systematic Review.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of Americawww.pnas.org Author Affiliations Communicated by J.
E. Rall, National Institutes of Health, Bethesda, MD, August 2, 2005 (received for review June 1, 2005) Abstract. High-Dose Vitamin C. Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany. + Author Affiliations Correspondence to: Professor Dr. med Josef Beuth, Institute for Naturopathy, University of Cologne, Joseph-Stelzmann-Str. 9/Building 35a, D-50931 Cologne, Germany.
Tel: +49 2214786414, Fax.: +49 2214787017, e-mail: email@example.com and Claudia Vollbracht, Pascoe pharmazeutische Präparate GmbH, D-35383 Giessen, Germany. h2rc2.com/cancer/page2/page7/assets/IVVitaminCGerman.pdf. Ascorbic acid: Chemistry, biology and the treatment of cancer. omicsonline.org/vitamin-c-in-cancer-treatment-where-pharmacokinetics-speaks-2157-7609.1000e107.pdf. www.actabp.pl/pdf/1_2001/233-240s.pdf. High-dose Vitamin C (Ascorbic Acid) Therapy in the Treatment of Patients with Advanced Cancer. Genetics and Molecular Biology - Anticlastogenic effect of vitamin C on cisplatin in vivo. Short Communication Anticlastogenic effect of vitamin C on cisplatin in vivo Lusânia M.
Greggi Antunes, Joana D.C. Effects of high doses of vitamins C and E against doxorubicin-induced chromosomal damage in Wistar rat bone marrow cells. Abstract Doxorubicin (DXR) is one of the major antitumoral agents available for clinical use.
In addition to intercalating into the DNA molecule, this drug generates free radicals. Vitamins C (VC) and E (VE) can protect normal cells from the damage caused by radicals without interfering with the cytotoxicity of DXR against tumors. The objective of the present study was to investigate the possible protective effect of VC and/or VE on mammalian cells treated with DXR in vivo. Protective effect of doxorubicin in vitamin C or dimethyl sulfoxide against skin ulceration in the pig. Background: Accidental extravasation of doxorubicin leads to skin necrosis and significant morbidity.
Based on our previous work in the rat, we hypothesized that the free radical scavengers dimethyl sulfoxide (DMSO) and vitamin C prevent doxorubicin-induced skin ulcers in white swine. Methods: Fifteen white swine were anesthetized and injected with 0.5 mg of doxorubicin (1 mg/ml) intradermally delivered in saline, 10% DMSO, 20% DMSO, vitamin C (1 mg/ml), or vitamin C in 20% DMSO. Presence of skin ulceration and ulcer size, in the two greatest dimensions, was determined weekly for 3 weeks.
Results: Delivery of doxorubicin in DMSO and/or vitamin C lowered the ulcer incidence from 87% to 27% (p<0.0001) when compared with delivery in saline. Conclusion: We conclude that the free radical scavengers DMSO and vitamin C are capable of lowering the incidence of doxorubicin-induced skin ulcers and could significantly lessen the morbidity associated with doxorubicin extravasation. Vitamins C and K3 Sensitize Human Urothelial Tumors to Gemcitabine. Purpose We evaluated the antitumor effects of vitamins C and K3 for human urothelial carcinoma and the potential use of the combination of vitamins C plus K3 as a sensitizing agent for conventional chemotherapy for urothelial carcinoma.
Materials and Methods The antiproliferative and apoptotic effects of vitamin C alone, vitamin K3 alone, vitamins C plus K3, gemcitabine alone and gemcitabine plus vitamins C plus K3 were assessed in vitro by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, propidium iodide staining and flow cytometry. For in vivo studies we implanted UMUC-14 tumorigenic urothelial carcinoma cells into the subcutis of nude mice. Anticlastogenic effect of Vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures.
Abstract Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damage induced by different agents. The protective effect of Vitamin C on cisplatin induced chromosome aberrations has been determined in the human peripheral lymphocyte chromosome aberration test in vitro. The results of treatments with Vitamin C indicated that it statistically significantly decreases the number of chromosome aberrations and number of metaphases with aberrations induced with cisplatin, but it can not completely protect cells from damage. The test concentrations of Vitamin C (10 and 100 μg/ml) had a limited antimutagen effect on cisplatin (0.5 μg/ml), which can cause genetic damage through free radical mechanisms. The effect of intratympanic vitamin C administration on cisplatin-induced ototoxicity. Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro.
Abstract Utilizing a microplate ATP bioluminescence assay, two human breast carcinoma cell lines, MCF-7 and MDA-MB-231, were tested against doxorubicin (DOX), cisplatin (DDP), and paclitaxel (Tx) alone and in combination with ascorbic acid (Vit C). In both cell lines, Vit C exhibited cytotoxic activity at high concentrations (i.e. 102–103 μM). Both cell lines also were resistant to DOX. MCF-7 was found to be DDP-resiseant, MDA-MB-231 was moderately sensitive to DDP. Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs.
+ Author Affiliations Requests for reprints: Mark L. Heaney, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021. Phone: 212-639-2275; Fax: 646-422-0640; E-mail: firstname.lastname@example.org. Abstract. Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany. + Author Affiliations Correspondence to: Professor Dr. med Josef Beuth, Institute for Naturopathy, University of Cologne, Joseph-Stelzmann-Str. 9/Building 35a, D-50931 Cologne, Germany. Tel: +49 2214786414, Fax.: +49 2214787017, e-mail: email@example.com and Claudia Vollbracht, Pascoe pharmazeutische Präparate GmbH, D-35383 Giessen, Germany.
integrativeveterinarycenter.com/wp-content/uploads/2012/02/FDA-seeks-to-limit-IV-vitamin-C-production-for-IV-therapy.pdf. Vitamin C Injections Slow Tumor Growth in Mice, August 4, 2008 News Release. Integrative Veterinary Center. integrativeveterinarycenter.com/wp-content/uploads/2012/02/vit_c_cancer_review.pdf. The Science of Vitamin C and Cancer: www.rath.co.uk/pdf-files/cancer_review_screen.pdf. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of Americawww.pnas.org Author Affiliations. Intravenously administered vitamin C as cancer therapy: three cases. + Author Affiliations Correspondence to: Dr. Mark Levine, Molecular and Clinical Nutrition Section, Bldg. 10, Rm 4D52–MSC 1372, National Institutes of Health, Bethesda MD 20892–1372; MarkL@mail.nih.gov.
Tribute to Pioneers. "...it takes much more than logic and clear-cut demonstrations to overcome the inertia and dogma of established thought. " — Irving Stone. Vitamin C Study Could Impact Mesothelioma Treatment, According to Surviving Mesothelioma.