Web2py. JavaScript GUI Framework - Ample SDK. Web2py: Enterprise Web Framework. Twisted. Twisted is an event-driven networking engine written in Python and licensed under the open source ​MIT license. Twisted runs on Python 2 and an ever growing subset also works with Python 3. Twisted makes it easy to implement custom network applications. Here's a TCP server that echoes back everything that's written to it: from twisted.internet import protocol, reactor, endpoints class Echo(protocol.Protocol): def dataReceived(self, data): self.transport.write(data) class EchoFactory(protocol.Factory): def buildProtocol(self, addr): return Echo() endpoints.serverFromString(reactor, "tcp:1234").listen(EchoFactory()) reactor.run()