Functional magnetic resonance imaging
Researcher checking fMRI images Functional magnetic resonance imaging or functional MRI (fMRI) is a functional neuroimaging procedure using MRI technology that measures brain activity by detecting associated changes in blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the Blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. The procedure is similar to MRI but uses the change in magnetization between oxygen-rich and oxygen-poor blood as its basic measure. This measure is frequently corrupted by noise from various sources and hence statistical procedures are used to extract the underlying signal. FMRI is used both in the research world, and to a lesser extent, in the clinical world. Overview History Three studies in 1992 were the first to explore using the BOLD contrast in humans.
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