Home | Leukaemia and Lymphoma Research - beating blood cancers Professor Ghulam Mufti | British Journal of Medical Practitioners Professor Ghulam Mufti qualified in Medicine at the University of Kashmir in 1973. He came to the UK in 1975, and commenced his training in haematology at Radcliffe Infirmary, Oxford, and Hammersmith Hospital Royal Postgraduate Medical School. Because of his interest in pre-leukaemic states, in 1981 the Leukaemia Research Fund awarded him a grant for a fellowship in Bournemouth, Southampton & Royal Posgratduate Medical School. He has extensive clinical and research expertise in myelodysplastic syndrome (MDS), leukaemias, and lymphomas. He has published numerous papers and chapters in scientific journals and textbooks on leukaemias. Professor Ghulam Mufti is head of the haematology department at King’s College Hospital.
Myelodysplastic Syndrome In some patients, MDS is an indolent disease. In the vast majority of the patients with MDS, the mortality is due to the cytopenias and resulting complications like bleeding and infections. In others, the disease follows an aggressive course and converts into an acute form of leukemia. Risk classification systems to estimate prognosis in patients with MDS have been developed by the French-American-British (FAB) Cooperative Group, the World Health Organization (WHO), and the MDS Risk Analysis Workshop. Refractory anemia (RA)RA with ringed sideroblasts (RARS)RA with excess blasts (RAEB; 6-20% myeloblasts)RAEB in transition to AML (RAEB-T; 21-30% myeloblasts)Chronic myelomonocytic leukemia (CMML) An underlying trilineage dysplastic change in the bone marrow cells is found in all subtypes. RA and RARS are characterized by 5% or less myeloblasts in bone marrow. RAEB and RAEB-T (see the image below) are characterized by greater than 5% myeloblasts. CMML may be associated with splenomegaly.
The Phrase, “Art and Science of Medicine.” Intestinal Volvulus Today News Reference Education Log In Register Print Intestinal Volvulus Updated: Jan 20, 2012 What would you like to print? Background Intestinal volvulus is defined as a complete twisting of a loop of intestine around its mesenteric attachment site. Volvulus involving the GI tract can cause severe clinical problems; the most feared complication is ischemia and necrosis of the entire midgut, which can be fatal. Laboratory findings are nonspecific. The management of abnormalities of rotation and volvulus is well established. Next Section: Anatomy Anatomy The midgut is that portion of the intestine supplied by the SMA. The bowel is relatively fixed at several points: the duodenum (including the duodenojejunal [DJ] junction), the ascending colon, the splenic flexure, and part of the descending colon. Previous Pathophysiology Embryology of GI tract A good understanding of the embryologic development of the GI tract is central to the understanding of malrotation and volvulus. Rotational abnormalities
Large bowel resection: MedlinePlus Medical Encyclopedia Large bowel resection is surgery to remove all or part of your large bowel. This surgery is also called colectomy. The large bowel is also called the large intestine or colon. Removal of the entire colon and the rectum is called a proctocolectomy. Removal of part or all of the colon but not the rectum is called subtotal colectomy. The large bowel connects the small intestine to the anus. Description You will get general anesthesia before your surgery. Depending on what type of procedure you have, your surgeon will make one or more cuts in your belly. With laparoscopic colectomy, the surgeon uses a tiny camera to see inside your belly and small instruments to remove part of your large bowel. You may also have a cut of about 2 to 3 inches if your surgeon needs to put a hand inside your belly to feel or remove the diseased bowel. For open colectomy, your surgeon will make a 6- to 8-inch cut in your lower belly. The surgeon will find the part of your colon that is diseased. Risks References
Mesenteric artery ischemia: MedlinePlus Medical Encyclopedia Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three mesenteric arteries, the major arteries that supply the small and large intestines. Causes Narrowing of the arteries that supply blood to the intestine causes mesenteric ischemia. Mesenteric artery ischemia is often seen in people who have hardening of the arteries in other parts of the body (for example, those with coronary artery disease or peripheral vascular disease). Mesenteric ischemia may also be caused by a blood clot (embolus) that moves through the blood and suddenly blocks one of the mesenteric arteries. Symptoms Symptoms of long-term (chronic) mesenteric artery ischemia caused by hardening of the arteries (atherosclerosis): Abdominal pain after eatingDiarrhea Symptoms of sudden (acute) mesenteric artery ischemia due to a traveling blood clot: DiarrheaSudden severe abdominal painVomiting Exams and Tests Treatment Acute mesenteric artery ischemia is an emergency. Outlook (Prognosis)
UK health service reforms Tomorrow’s doctors face a radically different NHS By: Adrian O’Dowd Published: 09 March 2011 DOI: 10.1136/sbmj.d1171 Cite this as: Student BMJ 2011;19:d1171 The government is planning far reaching reforms for the health service in England designed to shift control from the centre to local level and give doctors control of most of the NHS budget. The planned reforms were first unveiled in July of last year and are encapsulated in the Health and Social Care Bill currently progressing through parliament. The Bill passed its first reading in the House of Commons on 31 January and is currently being scrutinised (until 31 March) by 26 MPs on a Bill Committee before going back to the Commons for debate and amendments. If passed, the Bill will mean: For medical students, these changes will have a substantial impact on the environment in which they work. An issue that has prompted criticism from unions, representative bodies, and experts is the ability of private providers to bid alongside
News in brief: November 2011 Published: 27 October 2011 DOI: 10.1136/sbmj.d6934 Cite this as: Student BMJ 2011;19:d6934 The General Medical Council has decided not to register medical students. Registration with the GMC is required to practise medicine in the United Kingdom. But the GMC has concluded that registering all students before they qualify would bring no additional protection, benefit to the public, or increase patient safety. Student registration with the GMC would have brought consistency in fitness to practise disciplinary rulings. Registration would have also served to support students into professional practice and inform them about regulation. To read the rest of this article sign in or complete a FREE registration. Registration is quick, you only need to do this once and you get FREE access to all the Student BMJ content online.