MDMA Vault : In the Name of Science: Prior Exposure to MDMA May Block High-Dose Neurotoxicity "Practically any stimulus capable of causing injury to a tissue or organ can, when applied close to (but below) the threshold of damage, activate endogenous protective mechanisms--thus potentially lessening the impact of subsequent, more severe stimuli." -- Dirnagl et al. 20031 One of the more interesting neurotoxicity research findings over the last 25 years is that exposure to a low dose of a neurotoxin can provide protection against more severe damage from a later dose of the same substance. For methamphetamine, this was first documented in 1985,2 and in 2006, researchers found that "chronic, intermittent exposure" to MDMA in rats blocked severe damage to the serotonin system from a later high "binge" dose (Piper et al. 2006).3 A second research group recently published confirmation that pre-treatment with MDMA provides protection against a later neurotoxic dose (Bhide et al. 2009).4 Duration of the prophylactic effect is also unknown. Dirnagl U, Simon RP, Hallenbeck JM.
MUSHROOMS IN WONDERLAND | Brainwaving Was Alice in Wonderland and Victorian fairy art and lore in general inspired by actual experiences with mind-altering fungi? The first well-documented hallucinogenic mushroom experience in Britain took place in London’s Green Park on 3 October 1799. Like many such experiences before and since, it was accidental. © Mike Jay By chance, a doctor named Everard Brande happened to be passing through this insalubrious part of town, and he was summoned to treat J.S. and his family. Dr.Everard Brande would diagnose the family’s condition as the ‘deleterious effects of a very common species of agaric [mushroom], not hitherto suspected to be poisonous’. But if they were obscure to Victorian science, there was another tradition which would appear to explore the ability of certain mushrooms to whisk humans off to another world: Victorian fairy lore. The J.S. family’s trip in 1799 is a useful jumping-off point for such enquiries, because it establishes several basic facts.
Psychoactive Vaults : Psychedelic Crisis FAQ This FAQ is not regularly updated or maintained. It may include out-of-date information. Please check the version date to see when it was most recently revised. For current information, see Erowid's summary pages in the substance's main vault. Disclaimer This FAQ is presented for informational purposes only. Credits The information contained in this FAQ has been culled from a variety of sources. Revision History 0.5 - 09/10/97 - Assembled emails and passed around for comment 1.0 - 05/03/98 - Created the basic HTML, FAQ. 1.1 - 11/07/98 - Added index, disclaimer, credits, and significantly improved organization. 1.2 - 12/18/99 - Updated Antidotes section. 2.0 - 08/22/01 - Reorganized from a realtime usage perspective, added Assessment section 2.1 - 08/01/05 - Changed reference to CPR/Rescue Breathing in "Critical or Life Threatening Situation" section 2.2 - 02/17/14 - Added Tripsit link Introduction Assessment Type of Situation Is there immediate or potential physical danger? Quick List Summary
Ecstasy Slideshow (This Is Your Brain on Ecstasy) | DanceSafe.Org An MDMA Neurochemistry Slideshow © Copyright 1998-2014, Emanuel Sferios This slide show will explain the effects of MDMA on your brain. The effects of a normal dose of MDMA last from four to six hours. We will explain what happens in the brain during the various stages of the MDMA experience, and we will describe some changes in the brain that may occur after long-term, frequent use. The slideshow starts off with some fairly basic information and gets more complex as it goes along. The Brain This is a model of a typical human brain, showing some of the basic brain areas. Brain Cell This is a model of a typical type of brain cell called a neuron. A cell body, which stores the DNA and other things that the cell needs to do it’s job;Dendrites, which receive chemical signals from other cells; andAn axon, which carries an electrical signal from the cell body to the axon terminals. Serotonin is a neurotransmitter, and some brain cells have axons that contain only serotonin. Two Cells Vesicles
Psilocybin Psilocybin[nb 1] (/ˌsɪləˈsaɪbɪn/ SIL-ə-SY-bin) is a naturally occurring psychedelic compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms. The most potent are members of the genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from about a dozen other genera. As a prodrug, psilocybin is quickly converted by the body to psilocin, which has mind-altering effects similar (in some aspects) to those of LSD, mescaline, and DMT. In general, the effects include euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, and spiritual experiences, and can include possible adverse reactions such as nausea and panic attacks. History Early Modern Albert Hofmann (shown here in 1993) purified psilocybin and psilocin from Psilocybe mexicana in the late 1950s. Occurrence
The Heroine of Heroin – Upvoted Tracey Helton (Reddit user traceyh415) is the focus of this week’s episode. We discuss her depression growing up, how she became addicted to heroin, life as a homeless heroin addict, being the subject of the HBO documentary Black Tar Heroin, how she got clean, her involvement in harm reduction, how she got involved in Reddit’s opiates community, Naloxone, and how she saved the lives of over 120 users by sending naloxone to those with no access. Hold On "I lived in an all-female Pentecostal 'discipleship program' in rural Arkansas ... The Wave "Sailing remains one of the best things in my life. Four Walls and a Roof (Part One) "Our tent is a house. MDMA Preloading/Postloading Regimin This text is copied from This article is a MUST READ for anyone who is interested in taking ecstasy. I have rolled a few times without pre or post loading, and it SUCKS. The Effects of Ecstasy Think of your brain as the engine of a car. Preloading The concept behind preloading is to add gas to the tank that MDMA is going to use up, put the car in economy mode so it uses gas more efficiently, and to prevent damage to the engine if its driven too hard, especially if there's no gas in the tank. Protection The following three elements are the most protective to a preloading regimen: 1] 5-HTP - 200-400mg 5-hydroxytrytophan is the direct precursor of serotonin in the body. Enhancement The following elements are optional because they enhance the experience rather than protect you from anything specific: 1] L-Tyrosine - 500-1500mg Think of dopamine as engine oil. Protection 1] 5-HTP - 200-400mg 2] Vitamin C - 1000mg+ 3] Magnesium - 500-1000mg
‘Magic Mushrooms’ Return to Psych Labs 40 Years After Leary (Adds that psilocybin is a controlled substance in the sixth paragraph.) Dec. 6 (Bloomberg) -- Cancer survivor Lauri Reamer lived in constant dread that her disease would return, until she took a psychedelic drug in a Johns Hopkins University study. The 48-year mother of three was given psilocybin, the main ingredient in the “magic mushrooms” of the 1960s, as a remedy to ease anxiety. She spent most of her first “trip” crying, then emerged from the next with less anxiety, better sleep and happier relations with family and friends, she recalled. The experience “really cracked me open,” said Reamer, an anesthesiologist at Johns Hopkins in Baltimore before she was diagnosed with leukemia. Almost 40 years after Richard Nixon called former Harvard University psychologist Timothy Leary the most dangerous man in America for promoting use of hallucinogenic substances, there is a rebirth of interest in their therapeutic benefits. New Generation Anti-Smoking Study Harvard Project Cluster Headaches
Legal intoxicant - Wikipedia Legal intoxicants, also known as legal drugs or, more commonly, as legal highs, are those intoxicating drugs which are either completely legal or not commonly prohibited by various drug laws. The most widely consumed legal intoxicant is alcohol—legal throughout the vast majority of the world's countries—but a wide array of other drugs are also not specifically banned in many international jurisdictions: these may vary from native intoxicating plants historically used by indigenous cultures to foodstuffs eaten in various parts of the world, to modern compounds and designer drugs that have not been defined as illegal, or even long-standing medicines that have intoxicating or anesthetic side effects. Where legislation imposes a general ban on psychoactive substances (as in Ireland), legal intoxicants are limited to those substances specifically exempted. Stimulants Mephedrone Mephedrone a dopaminergic, serotonergic, and adrenergic stimulant. Caffeine Nicotine Khat