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Grandma's Experiences Leave Epigenetic Mark on Your Genes

Grandma's Experiences Leave Epigenetic Mark on Your Genes
Why can’t your friend “just get over” her upbringing by an angry, distant mother? Why can’t she “just snap out of it”? The reason may well be due to methyl groups that were added in childhood to genes in her brain, thereby handcuffing her mood to feelings of fear and despair. Of course, it is generally not possible to sample the brains of living people. But examining blood samples in humans is routine, and Szyf has gone searching there for markers of epigenetic methylation. Sure enough, in 2011 he reported on a genome-wide analysis of blood samples taken from 40 men who participated in a British study of people born in England in 1958. All the men had been at a socioeconomic extreme, either very rich or very poor, at some point in their lives ranging from early childhood to mid-adulthood. Timing, in other words, matters. A case study in the epigenetic effects of upbringing in humans can be seen in the life of Szyf’s and Meaney’s onetime collaborator, Frances Champagne. The Mark Of Cain

http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes

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Pericytes regulate the blood–brain barrier Affiliations Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden Annika Armulik, Guillem Genové, Maarja Mäe, Maya H. Nisancioglu, Elisabet Wallgard, Colin Niaudet, Liqun He, Jenny Norlin, Karin Strittmatter & Christer Betsholtz AstraZeneca AB, Clinical Development, SE-431 83 Mölndal, Sweden Per Lindblom The Electron Microscopy Unit, Institute for Biomedicine, The Sahlgrenska Academy, University of Gothenburg, PO Box 420, SE-405 30 Gothenburg, Sweden Bengt R. Johansson Present addresses: Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjölds väg 20, Uppsala University, SE-751 85 Uppsala, Sweden (E.W.); Applied Biosystems Sweden, Lindhagensgatan 76, PO Box 12650, SE-112 92 Stockholm, Sweden (L.H.); German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (K.S.). Elisabet Wallgard, Liqun He & Karin Strittmatter

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