Theta Entheo Discussion PiHKAL The book is arranged into two parts: A fictionalized autobiography of the couple.Detailed synthesis instructions for 179 different psychedelic compounds (most of which Shulgin discovered himself), including bioassays, dosages, and other commentary. The second part was made freely available by Shulgin on Erowid.org while the first part is available only in the printed text. Shulgin's choices of synthesis procedures in the second half of the book are themselves perhaps a small act of subversion: while the reactions are beyond the ability of people with a basic chemistry education, some tend to emphasize techniques that do not require difficult to obtain chemicals. Impact & popularity[edit] Through PIHKAL (and later TIHKAL), Shulgin sought to ensure that his discoveries would escape the limits of professional research labs and find their way to the public; a goal consistent with his stated beliefs that psychedelic drugs can be valuable tools for self-exploration. Notable excerpts[edit]
Dimethyltryptamine History[edit] Another historical milestone is the discovery of DMT in plants frequently used by Amazonian natives as additive to the vine Banisteriopsis caapi to make ayahuasca decoctions. Biosynthesis[edit] Biosynthetic pathway for N,N-dimethyltryptamine This transmethylation mechanism has been repeatedly and consistently proven by radiolabeling of SAM methyl group with carbon-14 (14C-CH3)SAM).[22][20][24][25][26] Evidence in mammals[edit] In 2013, researchers first reported DMT in the pineal gland microdialysate of rodents.[28] A study published in 2014 reported the biosynthesis of N,N-dimethyltryptamine (DMT) in the human melanoma cell line SK-Mel-147 including details on its metabolism by peroxidases. [29] In a 2014 paper, a group first demonstrated the immunomodulatory potential of DMT and 5-MeO-DMT through the Sigma-1_receptor of human immune cells. INMT[edit] Endogenous DMT[edit] The first claimed detection of mammalian endogenous DMT was published in June 1965: German researchers F.