Chromatin Immunoprecipitation Sequencing View Larger Image DNA enrichment by ChIP and SOLiD™ fragment library construction Comparison of ChIP Detection Platforms Chromatin immunoprecipitation (ChIP) is a method used to determine the location of DNA binding sites on the genome for a particular protein of interest. Microarray-based ChIP studies are restricted to a fixed number of probes Currently, the most common method for genome-wide analysis of DNA-binding proteins is Chip-on-chip (ChIP-chip), which combines chromatin immunoprecipitation with DNA microarrays. ChIP-Seq with the SOLiD™ System SOLiD™ System-based ChIP-Sequencing (ChIP-Seq) overcomes the limitation of microarrays by combining chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing, offering a highly sensitive, hypothesis-neutral method to accurately characterize the protein-DNA interactions of an entire genome. Experimental Workflow: Find the Products You Need for Every Step Click the arrows above to view products Step 1: Design Experiment
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When Research Turns Ugly: Beyond Geoffrey Miller's Fat-Shaming Tweet - After the negative response to a recent tweet, Geoffrey Miller locked his personal account. (TWITTER) In 2007, a university professor published research inspired by a former strip club manager purporting to show that human women, like other mammals, go into heat. Lap dancers make more money when they’re ovulating, according to the club manager turned evolutionary psychology student, who came to this conclusion by keeping tabs on the women’s tips. The study design (PDF) involved recruiting 18 lap dancers to record their menstrual cycles along with the amount of money earned per shift, and did appear to show that in a flagrantly sexual activity the women were earning more money when their biology suggested they would be the randiest. Extrapolating from the sex industry to the rest of the modern working world proved irresistible for Dr. Such crude advice comes routinely from the field of evolutionary psychology.
Compbio.mit.edu - MIT Computational Biology Group Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.
MGI-Mouse Genome Informatics-The international database resource for the laboratory mouse openSNP Blog | Juche Strong My brain tells me we’re now straddling a tectonic power shift in the film industry. Sustained technological innovation has dramatically driven down the price of the basic tools of film-making. The highest of high-tech cameras, lights, mics, editing software, etc. are all now exceedingly affordable and accessible. And the vast entrepreneurial stew of the web [...] Read more → (Originally posted at the Moving Picture Institute blog.) Head over to Indiegogo.com/Juchestrong. …then the political rhetoric that is enabling the Kim family to maintain control might share some similarities with the political rhetoric regularly deployed by American politicians.” The New Republic launched a massive redesign this week. This is a 60 second snippet I shot of the in-flight safety video run on North Korea’s airline. There are hours and hours of fascinating interview footage that aren’t going to make it into the final cut of the film.
Gene Expression Gateway Home - Bio-Rad Laboratories Cell Cycle & Cytokinesis - BioChemWeb.org Cell Cycle Regulation and the Control of Cell Proliferation (Cell Growth + Cell Division) Cell Cycle Research - General resource with links to relevant recent literature, news and job listings. (Ion Channel Media Group) Cell Division - Undergraduate-level lectures on cell division. (Cell Biology Lectures, Mark Hill, University of New South Wales, Australia) The Eukaryotic Cell Cycle and Cancer - Introduction to the eukaryotic cell cycle as it relates to the genetics of cancer. (Phillip McClean, North Dakota State University) (Just above Beginner's Level) ICRF FACS Laboratory Cell Cycle Analysis - Methods for cell cycle analysis using flow cytometry. (FACS Laboratory, Imperial Cancer Research Fund, UK) The Interactive Fly: Evolutionarily Conserved Pathways (Society for Developmental Biology). See also the Apoptosis, Cell Senescence and Signal Transduction pages. Mitosis, Meiosis and the Mechanics of Cell Division See also the Cytoskeleton, Cell Motility and Motors page. Cancer Resources