Fluorescent proteins designed from scratch Congrats to all Rosetta@home volunteers who contributed to a recent report in Nature describing the design of a completely artificial fluorescent beta-barrel protein. As described by one of the main authors, Anastassia, in this forum post: The paper presents many “firsts” in computational protein design. It is the first de novo design of the beta-barrel fold (one of the most described folds in the past 35 years, yet mysterious until now). It is also the first de novo design of a protein tailored to bind a small-molecule, which requires very high accuracy in the placement of side chains on protein backbones assembled from scratch. Thanks to all the Rosetta@home volunteers who contributed to the validation of our designed proteins and binding sites. Here is the link to the IPD webpage that contains a copy of the paper. Rosetta Android version 4.10 released ... more
