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Introduction to bioinformatics I will start by giving a general introduction into Bioinformatics, including basic biology, typical data types (sequences, structures, expression data and networks) and established analysis tasks. In the second part, I will discuss the problem of predictive sequence analysis with Support Vector Machines (SVMs). I will introduce a series of kernels suitable for different analysis tasks. Furthermore I will discuss the basic data structures needed for large scale learning and how to combine kernels for heterogeneous data. In the third part, I will focus on Hidden Markov models and discriminative alternatives like Conditional Random Fields and Hidden Markov SVMs suitable for segmentation tasks frequently appearing in Bioinformatics. In the last part I will present three applications in greater detail: A large margin alignment algorithm, computational gene finding and the identification of polymorphisms from resequencing arrays. Would you like to put a link to this lecture on your homepage?

de Gruyter Reference Global - Biomedizinische Technik/Biomedical Engineering Frontmatter Page i Published Online: 03/22/2014 Preface Editorial Patient customized engineering for smart cardiovascular therapy Schmitz-Rode, Thomas / Farkas, Robert Page 91 Published Online: 10/18/2013 Special issue articles Development of a prediction model on the acceptance of electronic laboratory notebooks in academic environments Kloeckner, Frederik / Farkas, Robert / Franken, Tobias / Schmitz-Rode, Thomas Page 95 Published Online: 11/13/2013 Individualized biomonitoring in heart failure – Biomon-HF “Keep an eye on heart failure – especially at night” Vollmer, Thomas / Schauerte, Patrick / Zink, Matthias / Glöggler, Sigrid / Schiefer, Johannes / Schiek, Michael / Johnen, Udo / Leonhardt, Steffen Page 103 Published Online: 02/18/2014 The Telemedical Rescue Assistance System “TemRas” – development, first results, and impact Page 113 Published Online: 01/18/2014 Save A novel approach in extracorporeal circulation: individual, integrated, and interactive heart-lung assist (I3-Assist) Page 125 Page 135

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